Novel Implementation of Microporous Annealed Particle HydroGel for Next-generation Posterior Pharyngeal Wall Augmentation
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Principal Investigator: James J. Daniero Organization: UNIVERSITY OF VIRGINIA Fiscal Year: 2024 Award: $121,125 Funding agency: National Institute of Dental and Craniofacial Research Synthetic hydrogels offer a promising platform for volumetric augmentation of the aerodigestive tract for precision medicine approaches. We propose that an ideal biomaterial platform for PPW augmentation to treat VPD would provide a durable tissue bulking effect, maintain implant configuration, and avoid FBR within a dynamic tissue environment. Specifically, Microporous Annealed Particle (MAP) hydrogels are an ideal material platform for the minimally invasive treatment of VPD. This novel biomaterial is a promising scientific advancement that has implications for improving VPD in patients with cleft and craniofacial conditions, particularly related to pharyngeal wall augmentation for managing VPD. There is a pressing need to utilize novel biomaterials and minimally invasive approaches to improve long-term outcomes for managing and resolving VPD. To address this need, we have developed a novel iteration of MAP hydrogel that is optimized for muscle implantation, tolerates dynamic movement, promotes excellent tissue integration, and provides persistent tissue bulk via 1:1 volume replacement with tissue de novo. Application of this unique biomaterial for PPW augmentation in an animal model will allow for novel analyses and new clinical applications for the MAP hydrogel. This proposal specifically aims to (1) quantify changes in pharyngeal wall anatomy in a rabbit model after pharyngeal wall augmentation and (2) identify the host-implant microenvironment required to achieve in situ tissue regeneration following optimized MAP gel pharyngeal wall augmentation. Terms: <3-D><3-Dimensional><3D><Acute><Address><Advanced Development><Aero-digestive Tract><Aerodigestive Tract><Affect><After Care><After-Treatment><Aftercare><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Biocompatible Materials><Biomaterials><Biomedical Engineering><Blood Vessels><Body Tissues><Calcium><Calcium Hydroxyapatite><Clinical><Collaborations><Collagen><Corium><Cutis><Data><Dermis><Detection><Domestic Rabbit><Durapatite><Dysfunction><Environment><Failure><Filler><Foreign-Body Reaction><Fostering><Functional disorder><Future><Gel><Generalized Growth><Goals><Growth><Hyaluronic Acid><Hydrogels><Hydroxylapatite><Immune><Immunes><Implant><In Situ><Inflammation><Injectable><Injections><Investigators><Light><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Methods><Microbeads><Microspheres><Modeling><Modernization><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Movement><Muscle><Muscle Tissue><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Oryctolagus cuniculus><Otolaryngology><Outcome><Outcome Assessment><Patients><Pharyngeal structure><Pharynx><Photoradiation><Physiology><Physiopathology><Plastic Surgical Procedures><Porosity><Pre-Clinical Model><Preclinical Models><Procedures><Rabbits><Rabbits Mammals><Reporting><Research Personnel><Researchers><Scientific Advances and Accomplishments><Second Look><Second Look Surgery><Speech><Speech Disorders><Speech Manifestations><Staining method><Stains><Surgical><Surgical Interventions><Surgical Management><Surgical Procedure><Surgical Revision><Technology><Throat><Time><Tissue Growth><Tissue Stains><Tissues><Vascularization><Visualization software><Voice Disorders><Zeugmatography><absorption><airway morbidity><bio-engineered><bio-engineers><bioengineering><biological engineering><biological material><body movement><care burden><clinical applicability><clinical application><conformation><conformational><conformational state><conformationally><conformations><craniofacial><craniofacies><early childhood><imaging science><immunogenicity><implantation><improved><in vivo><inflammation marker><inflammatory marker><innovate><innovation><innovative><manufacture><migration><minimally invasive><model of animal><muscular><next generation><novel><ontogeny><otorhinolaryngology><particle><pathophysiology><plastic surgery><post treatment><pre-clinical development><precision medicine><precision-based medicine><preclinical development><reconstruction><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><respiratory morbidity><retention rate><retention strategy><scientific accomplishments><scientific advances><success><surgery><three dimensional><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><vascular><visualization tool>