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Principal Investigator: MAARTEN G LANSBERG
Organization: STANFORD UNIVERSITY
Fiscal Year: 2024
Award: $411,862
Funding agency: National Institute of Neurological Disorders and Stroke
PROJECT SUMMARY
The Stanford Stroke Center, one of the first comprehensive multidisciplinary centers of its kind, was established in 1992 to develop new approaches to diagnose and treat stroke. The mission of the Stroke Center is to be the best comprehensive organization in the United States focused on stroke diagnosis, treatment, research, and education. In 1992, the Center was established by a team of neurologists, neurosurgeons, neuroradiologists, nurse specialists, basic scientists, and clinical researchers. This multi-disciplinary team has met regularly to continually refine the program for 30 years. In 2012, the Joint Commission and the American Heart Association/American Stroke Association announced that the Stanford Stroke Center was the first hospital in the United States to meet The Joint Commission's standards for Disease-Specific Care Comprehensive Stroke Center Certification. Stanford was chosen to be one of the original StrokeNet Regional Coordinating Centers (RCCs). During the initial grant period, Stanford developed the DEFUSE 3 study, which became the first clinical trial to be funded and executed by StrokeNet. This 40-site trial that tested the efficacy of endovascular therapy in the delayed time- window among patients selected with advanced neuroimaging techniques was extremely successful; enrollment rates were substantially ahead of projected targets and the trial stopped early for efficacy. The publication of the DEFUSE 3 trial results instantly changed practice guidelines and clinical practice around the world. It is now standard of care to treat patients with endovascular therapy in the delayed time-window if they meet DEFUSE 3 imaging criteria. This change in practice has nearly doubled the number of patients that can be treated with endovascular therapy. Stanford’s regional network is one of the highest enrollers in StrokeNet studies and Stanford faculty have made major contributions to key StrokeNet committees. The Stanford-RCC will continue to provide high volume enrollment of diverse patient populations into NINDS funded stroke trials. The Stanford RCC will also continue to offer an innovative multidisciplinary fellowship program that provides comprehensive training in clinical trial design, implementation and analysis. In addition, Stanford faculty members will continue to propose new clinical trials for implementation through StrokeNet.
Terms: <Acquired brain injury><American Heart Association><American Stroke Association><Ancillary Study><Apoplexy><Area><Basic Research><Basic Science><Blood Vessels><Brain Injuries><Brain Ischemia><Brain Vascular Accident><Brain Vascular Disorders><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Caring><Cerebral Brain Hemorrhage><Cerebral Hemorrhage><Cerebral Parenchymal Hemorrhage><Cerebral Stroke><Cerebral hemisphere hemorrhage><Cerebrovascular Apoplexy><Cerebrovascular Disease><Cerebrovascular Disorders><Cerebrovascular Stroke><Cerebrum Hemorrhage><Certification><Childhood stroke><Children's Hospital><Cilostazol><Clinical><Clinical Faculty><Clinical Nurse Educator><Clinical Research><Clinical Study><Clinical Trials><Clinical Trials Design><Clinical and Translational Science Awards><Collaborations><Collection><Coma><Comatose><Comprehensive Health Care><Comprehensive Healthcare><Computed Tomography><Country><Data Coordinating Center><Data Coordination Center><Data Set><Development><Diagnosis><Disease><Disorder><Education><Educational aspects><Emergency Medicine><Enrollment><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Evaluation><Faculty><Fellowship><Fellowship Program><Funding><Generations><Goals><Grant><Healthcare><Hospitals><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Infrastructure><Intervention><Intervention Strategies><Intracerebral Hemorrhage><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Investigators><Ischemic Encephalopathy><Joints><Laboratories><Laboratory Research><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Master of Science><Master's Degree><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Mission><NIH><NINDS><NMR Imaging><NMR Tomography><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Neuro rehabilitation><Neurologist><Neurology><Neurorehabilitation><Neurosurgeon><Nuclear Magnetic Resonance Imaging><Nurse Educator><Nurses><Nursing Faculty><Nursing Staff Developer><Nursing Staff Development Specialist><Patient Selection><Patients><Pediatric Hospitals><Phase><Physicians><Pletal><Practice Guidelines><Procedures><Prognosis><Protocol><Protocols documentation><Publications><Publishing><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized, Controlled Trials><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Running><Scientific Publication><Scientist><Selection Criteria><Site><Specialist><Stroke><Stroke prevention><Techniques><Testing><Time><Tomodensitometry><Training><United States><United States National Institutes of Health><Universities><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><acute cerebrovascular accident><acute stroke><big imaging data><brain attack><brain damage><brain tissue><brain vascular disease><brain vascular dysfunction><brain-injured><catscan><cerebral vascular accident><cerebral vascular disease><cerebral vascular dysfunction><cerebrovascular accident><cerebrovascular dysfunction><clinical center><clinical practice><clinical trial implementation><comprehensive care><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><data management and coordinating center><data management center><design><designing><developmental><efficacy testing><enroll><epidemiologic investigation><epidemiology study><experience><health care><imaging><imaging approach><imaging based approach><implementation of clinical trials><innovate><innovation><innovative><interventional strategy><intracranial vascular dysfunction><large imaging data><large-scale imaging data><medical college><medical schools><member><multidisciplinary><neural imaging><neuro-imaging><neuro-surgeon><neuro-vascular><neuroimaging><neurological imaging><neurological rehab><neurological rehabilitation><neurorehab><neurorehabilitative><neurosurgery><neurovascular><new approaches><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel approaches><novel strategies><novel strategy><nurse><participant enrollment><patient enrollment><patient population><pediatric stroke><prevent stroke><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><programs><randomized control trial><school of medicine><standard of care><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stroke patient><stroke recovery><stroke therapy><stroke treatment><stroke trials><stroked><strokes><success><treating stroke><trial enrollment><vascular>