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Principal Investigator: MICHAEL S TORBENSON
Organization: MAYO CLINIC ROCHESTER
Fiscal Year: 2024
Award: $336,496
Funding agency: National Cancer Institute
BIOSPECIMEN AND PATHOLOGY CORE C – PROJECT SUMMARY
The Biospecimen and Pathology Core (Core C) collects and annotates biospecimens with clinical data to meet
the needs of the three Translational Research Projects, Developmental Research and Career Enhancement
Programs, and investigators engaged in hepatobiliary cancer research globally. Core C incorporates the Core
HB SPORE Registry and Biorepository, and additional biorepositories at Mayo Clinic and other institutions,
including the Genetics of Cholestatic Liver Diseases Registry (Dr. Konstantinos Lazaridis), Liver Transplant
Registry (Dr. Timucin Taner), and the Hepatobiliary Cancer Patient-Derived Xenograft (PDX) program (Dr. Mark
Truty). Core C coordinates with The Fibrolamellar Carcinoma Biorepository at Rockefeller University (Dr. Sanford
Simon). Core C provides sample accessioning and pathology support for early phase clinical trials as needed in
SPORE projects, coordinates with the Mayo Clinic Biospecimen Accessioning and Processing (BAP) Shared
Resource to process blood samples to genomic DNA and serum and plasma aliquots, and with the Pathology
Research Core (PRC) to provide tissue-based services, including frozen and paraffin sections,
immunohistochemistry (IHC), FISH, tissue microarray (TMA), and digital imaging. The Department of Surgical
Pathology facilitates acquisition of fresh tissue for research at the time of surgery. We have initiated a major
focus on diversity. The aims are:
Specific Aim 1. Provide clinically annotated blood-derived, bile, stool, and urine specimens.
Specific Aim 2. Provide clinically annotated frozen and formalin-fixed tissue specimens, histopathologic
characterization, and histology-related laboratory services.
Specific Aim 3. Provide clinically annotated fresh tissues, PDXs, organoids, cell lines and animal models.
Requests for biospecimens are reviewed by the SPORE Biospecimen Access Committee for Hepatobiliary
Cancers: (BAC-HEP), with priority access for the four SPORE Translational Research Projects, the
Developmental Research and Career Enhancement Programs, and other SPORE investigators.
Director: Dr. Michael Torbenson (Liver pathology). Focus is histology and pathology services including
detailed annotation of frozen and formalin-fixed paraffin-embedded tissue, IHC, and animal models.
Co-Director: Dr. Lewis Roberts (Hepatology). Focus is building collaborative network and agreements, IRB
protocol maintenance, coordination of consenting, abstraction, curating, and shipping of specimens.
Co-investigator: Dr. Zongming Chen (Liver Pathology). Focus is supporting pathology core services.
Co-investigator: Dr. Kirk Wangensteen (Hepatology). Focus is supporting registry and biorepository services.
All shared resources are available to all members of the worldwide scientific community if the appropriate ethical
and legal permissions are obtained, within the limits of specimen availability and project feasibility.
Terms: <Age><Agreement><Aliquot><Animal Model><Animal Models and Related Studies><Arizona><Authorization><Authorization documentation><BAC clone><BACs><Bacterial Artificial Chromosomes><Bile><Bile Duct Obstruction><Bile Juice><Bile fluid><Biliary Stasis><Biological><Blood><Blood Plasma><Blood Platelets><Blood Reticuloendothelial System><Blood Sample><Blood Serum><Blood specimen><Body Tissues><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cancer Model><Cancer Patient><Cancer Treatment><CancerModel><Cancers><Cell Line><CellLine><Cessation of life><Cholangiocarcinoma><Cholangiocellular Carcinoma><Cholestasis><Clinic><Clinical><Clinical Data><Collaborations><Communities><Consent><Core Facility><DNA><Data><Death><Deoxyribonucleic Acid><Development><Diagnostic><Dietary History><Dissociation><Drugs><Eligibility><Eligibility Determination><Ethics><Family><Feces><Fibrolamellar Hepatocellular Carcinoma><Florida><Formalin><Freezing><Fresh Tissue><Funding><Future><Gender><Genetic><Genomic DNA><Germ Lines><Goals><Hepatic Cancer><Hepatic Transplantation><Hepatobiliary><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatology><Hepatoma><Histology><History><Human><IRB><IRBs><Immunocompetent><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Infrastructure><Institution><Institutional Review Boards><International><Investigators><Joints><Knock-out><Knockout><Laboratories><Legal><Link><Liver><Liver Cell Fibrolamellar Carcinoma><Liver Cells Carcinoma><Liver Grafting><Liver Transplant><Maintenance><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Marrow platelet><Mayo Clinic Cancer Center><Medical History><Medication><Medidata><Mission><Modern Man><On-Line Systems><Oncocytic Hepatocellular Tumor><Online Systems><Operating Rooms><Operative Procedures><Operative Surgical Procedures><Organoids><Outcome><P01 Mechanism><P01 Program><PDX model><Paraffin><Paraffin Embedding><Paraffin waxes and Hydrocarbon waxes><Pathologic><Pathology><Patient derived xenograft><Patients><Permission><Personal Medical History><Personal Medical History Epidemiology><Pharmaceutical Preparations><Phenotype><Plasma><Plasma Serum><Platelets><Polygonal Cell Type Hepatocellular Carcinoma with Fibrous Stroma><Population Heterogeneity><Primary carcinoma of the liver cells><Process><Program Project Grant><Program Research Project Grants><Protocol><Protocol Screening><Protocols documentation><R-Series Research Projects><R01 Mechanism><R01 Program><Recording of previous events><Registries><Research><Research Grants><Research Personnel><Research Program Projects><Research Project Grants><Research Projects><Research Resources><Research Specimen><Researchers><Resected><Resource Sharing><Resources><Reticuloendothelial System, Serum, Plasma><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Serum><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shipping><Single cell seq><Site><Sleeping Beauty><Specimen><Staining method><Stains><Strains Cell Lines><Surgical><Surgical Interventions><Surgical Pathology><Surgical Procedure><T-Stage><Thrombocytes><Time><Tissue Arrays><Tissue Chip><Tissue Embedding><Tissue Microarray><Tissue Sample><Tissues><Toxin><Transgenic Organisms><Translational Research><Translational Science><Tumor stage><Universities><Urine><ages><anti-cancer research><anti-cancer therapy><bile obstruction><bile occlusion><biliary cancer><biobank><biologic><biorepository><burden of disease><burden of illness><cancer research><cancer specimen resource><cancer therapy><cancer-directed therapy><career><cholangiosarcoma><cholestatic diseases><cholestatic disorder><cholestatic liver disease><cholestatic liver disorder><cholestatic syndromes><computer imaging><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cultured cell line><demographics><depository><developmental><diet history><digital imaging><disease burden><disease registry><diverse populations><drug/agent><early clinical trial><early phase clinical trial><ethical><fibrolamellar carcinoma><gDNA><hepatic body system><hepatic organ system><hepatobiliary cancer><heterogeneous population><histories><human tissue><hypoimmunity><immune competent><immune deficiency><immunodeficiency><liver cancer><liver carcinoma><liver malignancy><liver transplantation><malignancy><malignant liver tumor><member><model of animal><mouse model><murine model><neoplasm/cancer><online computer><patient derived xenograft model><population diversity><prevent><preventing><programs><prospective><repository><response to therapy><response to treatment><sample collection><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><single cell next generation sequencing><single cell sequencing><specimen collection><stool><success><surgery><therapeutic response><therapy response><tissue fixing><transgenic><translation research><translational investigation><transplant registry><treatment response><treatment responsiveness><tumor><under served community><underserved community><virtual><web based>