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Principal Investigator: Sallie R. Permar
Organization: WEILL MEDICAL COLL OF CORNELL UNIV
Fiscal Year: 2023
Award: $480,199
Funding agency: National Institute of Allergy and Infectious Diseases
ABSTRACT – Nonhuman Primate Core (NHP Core/ Core 1)
The end of the HIV/AIDS epidemic will be achievable only when an effective vaccine regimen can achieve
long-term protective immunity, similar to that of vaccines that have nearly eliminated other global pathogens.
HIV acquisition risk begins in utero and continues through the period of breastfeeding, then starts again at the
time of sexual debut and continues into adulthood. Prevention of HIV through adulthood will require an active
vaccine that elicits persistent immunity. Yet, current HIV vaccine platforms have failed to induce highly-
protective immunity in adults in preclinical and clinical studies. Excitingly, recent studies indicate that achieving
durable, polyfunctional, and bnAb responses following HIV infection may be more easily achieved in infancy
than in an adult immune system. Yet, gaps remain in our understanding of whether HIV vaccination in early life
is advantageous for achievement of protective, long lasting HIV immunity. Because of its many similarities in
development, physiology, immunology and pathogenesis, nonhuman primate (NHP) models of HIV infection
are highly appropriate to explore these research questions. Thus, this HIVRAD Program will use the NHP
model to test the hypothesis that HIV Env vaccine platforms administered in early life and boosted in pre-
adolescence will achieve durable, polyfunctional, and mature immune responses that will be more efficacious
at prevention of sexual transmission than immunization starting in preadolescence. In this renewal, the NHP
Core will continue to support NHP studies in Project 1, “Age-related impact on early life B cell lineage-designed
SOSIP HIV Env vaccination” (P.I. Dr. S. Permar, Duke University) and Project 2, “RNA vaccination in early life
to induce potent and broad HIV Env-specific antibody responses“ (P.I. Dr. K. De Paris, UNC-CH). Projects test
the same hypothesis using 2 different vaccine platforms, SOSIP and mRNA-LNP, respectively. The
Nonhuman Primate Core (NHP Core) is an integral component of the overall HIVRAD Program and
provides direct support to the Projects by coordinating and implementing all the NHP experiments
(including regulatory approvals, and all procedures related to immunizations and sample collections), and by
developing/testing a repeated low-dose rectal SHIV challenge model in adolescent macaques to test vaccine
efficacy. This Core has a longstanding track-record of collaboration with the 2 Project Leads/Overall P.I’s, and
will communicate frequently with both Projects and other Cores to assure all the experimental needs are met
with due diligence. The NHP Core uses the unique resources and infrastructure of the California National
Primate Research Center (CNPRC), out of which it operates, and the expertise of the Core Lead and staff. The
CNPRC is built on a service-oriented and interdisciplinary mission of advancing non-human primate models of
human diseases and translational research. Resources at CNPRC include a large rhesus macaque breeding
colony, experience with time-mated pregnancies, nursery-rearing of infant macaques, and all other procedures
of monitoring and sample collections that are essential to the successful completion of the Projects.
Terms: <12-20 years old><21+ years old><4 year old><4 years of age><AIDS Virus><AIDS prevention><AIDS/HIV><Achievement><Achievement Attainment><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adherence><Adolescence><Adolescent><Adolescent HIV><Adolescent Youth><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Animals><Antibodies><Antibody Response><Assay><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bioassay><Biologic Assays><Biological Assay><Blood Plasma><Breast Feeding><Breast fed><Breastfed><Breastfeeding><Breeding><California><Cell Lineage><Childhood><Clinical><Clinical Data><Clinical Research><Clinical Study><Collaborations><Communication><Data><Data Bases><Databases><Decision Making><Dedications><Development><Dose><E-Mail><Electronic Mail><Email><Ensure><Epidemic><Gestation><Goals><HIV><HIV Infections><HIV Prevention><HIV infection in adolescence><HIV infections in adolescents><HIV vaccine><HIV-1><HIV-I><HIV-infected (HIV+) adolescents><HIV-infected adolescents><HIV/AIDS><HIV/AIDS Vaccines><HIV/AIDS prevention><HIV1><HTLV-III Infections><HTLV-III-LAV Infections><Health><Housing><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Human immunodeficiency virus 1><Immune response><Immune system><Immunity><Immunization><Immunochemical Immunologic><Immunologic><Immunological><Immunological response><Immunologically><Immunologics><Immunology><Infant><Infection><Infrastructure><LAV-HTLV-III><Lead><Life><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><Macaca><Macaca mulatta><Macaque><Maintenance><Measures><Messenger RNA><Mission><Modeling><Monitor><North Carolina><Paris><Paris, France><Partner in relationship><Pathogenesis><Pb element><Physiology><Plasma><Plasma Serum><Preclinical Testing><Pregnancy><Prevention><Primates><Primates Mammals><Procedures><Progress Reports><R-Series Research Projects><R01 Mechanism><R01 Program><RNA immunization><RNA vaccination><Rectum><Regimen><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Reticuloendothelial System, Serum, Plasma><Rhesus Macaque><Rhesus Monkey><Risk><Route><SHIV><SIV><Safety><Sampling><Services><Sexual Transmission><Simian Immunodeficiency Viruses><Specificity><System><Testing><Time><Translational Research><Translational Science><Transmission><Universities><Update><Vaccination><Vaccine Research><Vaccines><Viral><Virus><Virus-HIV><adolescence (12-20)><adolescents with HIV><adulthood><age 4 years><age dependent><age effect><age related><aging effect><animal data><conference><convention><data base><design><designing><develop a vaccine><develop vaccines><development of a vaccine><developmental><electronic communication><evaluate vaccines><experience><experiment><experimental research><experimental study><experiments><four year old><four years of age><heavy metal Pb><heavy metal lead><host response><human disease><human immunodeficiency virus vaccine><human model><immune system response><immunoresponse><in utero><infancy><infantile><initiation of sexual activity><juvenile><juvenile human><mRNA><mRNA immunization><mRNA vaccination><mate><meeting><meetings><microbiome><model of animal><model of human><neutralizing antibody><non-human primate><nonhuman primate><pathogen><pediatric><pre-adolescent><pre-clinical study><pre-clinical testing><preadolescence><preclinical study><preteen><prevent><preventing><programs><rectal><response><sample collection><sexual debut><sexual initiation><sexually transmitted><simian HIV><simian human immunodeficiency virus><specimen collection><summit><symposia><symposium><translation research><translational investigation><transmission process><vaccine development><vaccine efficacy><vaccine evaluation><vaccine platform><vaccine screening><vaccine strategy><vaccine testing><vaccine-related research><viral RNA><virus RNA>