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Principal Investigator: Subhojit Roy
Organization: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Fiscal Year: 2024
Award: $512,173
Funding agency: National Institute on Aging
The focus of this Neuropathology (NP) Core renewal is to collaborate with other Center Cores to achieve
specific aims related to ADRD nervous system tissue acquisition, pathologic diagnosis, and research
utilization and distribution. Our Core endeavors to advance understanding of neurodegenerative disease
mechanisms by utilizing innovative approaches including multi-omic studies, collaborating with other Cores,
and emphasizing study of diverse populations. The first aim of the NP Core is to perform tissue autopsy on
diverse populations and disease states, with a continued focus on increasing the diversity of the patient
cohort who receives detailed neuropathologic evaluations, particularly Latino participants. We will also
prioritize collection of healthy control cases and cases with early-stage pathology. We have prioritized both
of these populations at our Center and continue to increase the proportion of autopsies from these groups.
Second, we will perform comprehensive neuropathological analysis and diagnosis according to the National
Alzheimer’s Coordinating Center (NACC) NP Form 11 Guidelines using detailed H&E and immunostaining
analysis (tau, Abeta, alpha-synuclein, and TDP-43) with data uploaded to the NACC database for sharing.
Third, the NP Core will continue its onsite and collaborative research efforts to understand the mechanisms
underlying neuropathologic heterogeneity and the co-occurrence of multiple pathologies. This will involve
distributing banked tissue to researchers outside of our Center and, within our Center, leveraging the
synergy between robust clinical neuropsychological studies, expertise in digital pathology, and ongoing
collaborations utilizing RT-QuIC. Fourth, the NP Core places a strong emphasis on mentoring the next
generation of NP researchers, particularly young and underrepresented scientists. We will provide
resources and training opportunities, including access to ADRC tissue and core resources, to support their
research and development, in collaboration with our REC core. Finally, the NP Core aims to advance novel
molecular approaches using postmortem tissue, specifically focusing on cell type-specific multi-omics
transcriptomics. We will integrate post-mortem transcriptomic data with data from neuronal models
developed by their iPSC Core, including direct-induced neurons and iPSC-neurons. In summary, the NP
Core's specific aims focus on performing tissue autopsies, executing comprehensive neuropathological
analysis, managing and sharing specimen resources, mentoring young researchers, and advancing novel
molecular approaches. These objectives collectively contribute to the Core's mission of advancing the
understanding of neurodegenerative diseases and fostering the development of future neuropathologists
and neuroscientists.
Terms: <AD dementia><AD pathology><AIDS><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Amentia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Assay><Autopsy><Aβ><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><California><Cessation of life><Clinical><Collaborations><Collection><Data><Death><Degenerative Neurologic Disorders><Dementia><Development><Development and Research><Diagnosis><Diagnostic><Disease><Disorder><Dura><Dura Mater><Early Diagnosis><Encephalon><Ensure><Equipment and supply inventories><Evaluation><Eye><Eyeball><FTLD><Faculty><Fostering><Freezing><Frontotemporal Lobar Degenerations><Frontotemporal variety lobar degeneration><Future><Goals><Guidelines><HIV associated neurological disease><HIV associated neurological disorder><Heterogeneity><Induced Neurons><Induced pluripotent stem cell derived neurons><Institution><International><Inventory><Investigators><LB dementia><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Lewy Body Dementia><Lewy Body Type Senile Dementia><Lewy dementia><MT-bound tau><Mentors><Methodology><Methods><Mission><Modeling><Molecular><NAC precursor><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Body System><Neurologic Degenerative Conditions><Neurologic Organ System><Neuron Degeneration><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Neuropsychologies><Neuropsychology><PARK1 protein><PARK4 protein><Participant><Pathologic><Pathology><Patients><Population><Population Heterogeneity><Primary Senile Degenerative Dementia><Procedures><Proteins><R & D><R&D><Research><Research Personnel><Research Resources><Research Specimen><Research Support><Researchers><Resources><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SNCA><SNCA protein><Sampling><Scientist><Series><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Skin><Specimen><Staining method><Stains><Standardization><Students><System><TAR DNA-binding protein 43><TDP-43><TDP43><Tauopathies><Tissue Banks><Tissue Collection><Tissue repository><Tissues><Training><Work><a beta peptide><a-syn><a-synuclein><abeta><age associated><age correlated><age dependent><age linked><age related><age specific><alpha synuclein><alpha synuclein gene><alphaSP22><amyloid beta><amyloid-b protein><asyn><beta amyloid fibril><biobank><biorepository><brain tissue><case control><case-controlled><cell type><cohort><conference><convention><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><digital pathology><diverse populations><early detection><epigenomics><heterogeneous population><iNeuron><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent stem cell><innovate><innovation><innovative><interest><limbic-predominant age-related TDP-43 encephalopathy><limbic-predominant age-related TDP43 encephalopathy><microtubule bound tau><microtubule-bound tau><multiomics><multiple omics><necropsy><neural degeneration><neuro-AIDS><neuro-HIV><neuroAIDS><neuroHIV><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neurons derived from induced pluripotent stem cells><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><neuropsychologic><new diagnostics><next generation><next generation diagnostics><non A-beta component of AD amyloid><non A4 component of amyloid precursor><novel><novel diagnostics><panomics><participant enrollment><patient enrollment><population diversity><postmortem><primary degenerative dementia><prion-like><protein TDP-43><protein TDP43><research and development><senile dementia of the Alzheimer type><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><shared data base><shared database><soluble amyloid precursor protein><summit><symposia><symposium><synergism><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau factor><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tauopathic neurodegenerative disorder><tauopathy><training opportunity><transcriptomics><work group><working group><α synuclein gene><α-syn><α-synuclein><τ Proteins>