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Principal Investigator: Shoshannah Iylene Eggers
Organization: UNIVERSITY OF IOWA
Fiscal Year: 2024
Award: $242,325
Funding agency: National Institute of Environmental Health Sciences
PROJECT SUMMARY
I am an environmental epidemiologist and microbiome researcher with a primary research interest in the role of
the human microbiome between environmental exposures and human health, including neurological outcomes.
The goal of this proposal is to obtain training and acquire the skills needed to continue to build my academic
research career by linking early life metal exposure, the gut microbiome and metabolome in childhood, and
neurodevelopmental measures of attention.
For this proposal, I plan to train with an expert team of mentors, collaborators, and advisors with
transdisciplinary expertise in exposomics, exposure biology, neurodevelopment, biostatistics, metabolomics,
epidemiology, and microbiome research. The proposed training plan includes clinical and laboratory rotations,
coursework, seminars and meetings, conferences, and 1-on-1 tutorials with mentors and advisors, covering
research and career development topics. This training will provide skills and knowledge in the areas of
neurodevelopment, and exposomics, including exposure biology and multi-omics analysis. Upon completion of
this training plan, I will be able to achieve my long-term career goal of becoming an independent researcher
focused on the inter-relationships among environmental exposures, the microbiome, and neurodevelopment.
To that end, I propose leveraging the use of the established Programming Research in Obesity, GRowth,
Environment and Social Stressors (PROGRESS) birth cohort, based in Mexico City, and adding microbiome
analysis. Specifically, I will: 1) train with Dr. Arora in exposure biology and analysis of baby teeth as a
biomarker of early life metal exposure; 2) train with Dr. Wright, in collaboration with Dr. Shamesh, in
neurodevelopmental assessment, principals of neurotoxicology, and their use in epidemiologic studies; 3) train
with Dr. Faith in metagenomic analysis, 4) integrate biostatistical assessment of mixtures and high dimensional
data, guided by Dr. Gennings; 4) learn about stool metabolomic analysis methodology with Dr. Walker; 5) work
with Dr. Tellez-Rojo to facilitate stool sample collection and data analysis in PROGRESS. I will use these
training and research activities to integrate the microbiome into an exposomic analysis of neurodevelopment. I
will use the research and career development training I receive to establish myself as an independent
investigator with a tenure track faculty position, able to secure R01 funding.
This research proposal combines innovative measures of exposure, novel data analysis approaches,
and high resolution omics analysis to address gaps in the understanding of timing and potential mechanisms
by which metal exposures, and the gut microbiome and metabolome, are associated with neurodevelopmental
measures of attention. The proposed research and training plan builds the foundation for an independent
research career that aims to clarify the links between environmental exposures and neurodevelopment, via the
human microbiome.
Terms: <11 year old><11 years of age><12-20 years old><2nd trimester><Address><Adolescence><Aeroseb-HC><Age><Area><Attention><Behavioral><Biological><Biological Markers><Biology><Biometrics><Biometry><Biostatistics><Birth><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><Cetacort><Chemical Exposure><Chemicals><Childhood><Cities><Clinical><Collaborations><Copper><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Cu element><Data><Data Analyses><Data Analysis><Dermacort><Development><Development and Research><Disease Frequency Surveys><Eldecort><Encephalon><Environment><Environmental Epidemiology><Environmental Exposure><Environmental Health><Environmental Health Science><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiologist><Epidemiology Research><Faculty><Faith><Feces><Foundations><Functional Metagenomics><Funding><Future><GI microbiome><Generalized Growth><Goals><Growth><Hair><Health><Human><Human Microbiome><Hydrocortisone><Hydrocortone><Hytone><Individual><Infant><Intervention><Intervention Strategies><Investigators><Knowledge><Laboratories><Lead><Learning><Life><Link><Manganese><Measurement><Measures><Mediation><Mentors><Mentorship><Metabolic><Metagenomics><Metal exposure><Metals><Methodology><Mexico><Microbiology><Microbiomics><Midtrimester><Mn element><Modeling><Modern Man><NIEHS><National Institute of Environmental Health Sciences><Negotiating><Negotiation><Neural Development><Neurologic><Neurologic outcome><Neurological><Neurological outcome><Nutracort><Obesity><Observation research><Observation study><Observational Study><Observational research><Parturition><Pathway interactions><Pb element><Play><Position><Positioning Attribute><Predisposition><Proctocort><Proteobacteria><Protocol><Protocols documentation><Purple Bacteria><R & D><R&D><Research><Research Activity><Research Personnel><Research Proposals><Researchers><Resolution><Role><Rotation><Second Pregnancy Trimester><Second Trimester><Secure><Shapes><Shotguns><Susceptibility><Time><Tissue Growth><Tooth><Tooth structure><Training><Training Activity><Work><Zinc><Zn element><adiposity><adolescence (12-20)><age 11 years><ages><analyze microbiome><bacteria in the gut><behavior measurement><behavioral measure><behavioral measurement><bio-markers><biologic><biologic marker><biomarker><career><career development><cohort><conference><convention><corpulence><data interpretation><developmental><digestive tract microbiome><early biomarkers><early detection biomarkers><early detection markers><early life exposure><eleven year old><eleven years of age><enteric microbiome><epidemiologic investigation><epidemiology study><executive control><executive function><exposed in utero><exposure to metal><fecal sample><fetal><fetal exposure><gastrointestinal microbiome><gut bacteria><gut microbiome><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><heavy metal Pb><heavy metal lead><high dimensional data><human-associated microbiome><in utero exposure><infancy><infantile><innovate><innovation><innovative><interest><interventional strategy><intestinal biome><intestinal microbiome><intra-uterine environmental exposure><intrauterine environmental exposure><meeting><meetings><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome analysis><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><multidimensional data><multidimensional datasets><multidisciplinary><multiomics><multiple omics><neurobehavioral><neurodevelopment><neurotoxicology><novel><ontogeny><panomics><pathway><pediatric><pilot test><prenatal><prenatal exposure><prenatally exposed><prospective><research and development><resolutions><sample collection><shot gun><skill acquisition><skill development><skills><social role><social stresses><social stressor><specimen collection><stool><stool sample><stool specimen><success><summit><symposia><symposium><teeth><tenure process><tenure track><time use><training module><unborn>