Document text
Principal Investigator: Julie Dang
Organization: UNIVERSITY OF CALIFORNIA AT DAVIS
Fiscal Year: 2024
Award: $167,940
Funding agency: National Cancer Institute
This K01 award resubmission outlines an intensive five-year research career development program
focused on multilevel behavioral intervention and dissemination and implementation science research to
increase and sustain uptake of the human papillomavirus (HPV) vaccine. Supporting the candidate's career
and research goals is a mentoring team comprised of experts in behavioral intervention research, advanced
biostatistics methods, and dissemination and implementation science as well as a clinical expert panel.
Completion of the candidate's training plan and research study will provide the candidate with the experience,
skills, knowledge, mentoring and pilot data needed to become a leading independent investigator in
developing, implementing and evaluating multilevel behavioral interventions to reduce the burden of cancer in
racial/ethnic minority groups, starting with increasing HPV vaccination rates.
The HPV vaccine is a major public health breakthrough and is the optimal primary prevention strategy
against HPV-associated cancers. Widespread use of the HPV vaccine is expected to reduce the cancer
burden across all racial/ethnic group, as populations of color are disproportionately affected by HPV-
associated cancers. Despite CDC recommendations and the public health implications of full vaccination
coverage, HPV vaccine uptake among adolescents remains well below the Healthy People 2030 goal of 80%.
The National Immunization Survey reported that in 2019, only 54.2% of U.S. adolescents aged 13-17 were up
to date with the series. Preliminary data and a review of the literature suggest multilevel interventions that
address at least two levels influence show promise in increasing HPV vaccine uptake. The objective of this
proposal is to develop, implement and evaluate a multilevel (parent, primary care team, and clinic) intervention
aimed at raising adolescent HPV vaccination rates to the Healthy People 2030 goal of 80% for boys and girls
using a parallel group cluster randomized trial design. This study will assess the effectiveness of the multilevel
intervention on increasing the rates of HPV vaccination among patients aged 9-17 of a primary care network
and will identify barriers and facilitators for broad dissemination and implementation. This will be accomplished
through the following aims: 1) Refine and finalize a parent, primary care team and clinic ML intervention to
increase uptake and completion of the HPV vaccine series among adolescent patients of a primary care
network; and 2) Conduct and evaluate the effectiveness and sustainability of the ML intervention. The
proposed research is significant because it will contribute to the emerging field of HPV vaccination multilevel
intervention research and addresses the need for more scientifically rigorous, evidence-based interventions
that can be disseminated and implemented on a large scale. Successful adoption of widespread HPV vaccine
coverage programs will reduce racial/ethnic disparities in HPV-associated cancer by ensuring that the next
generation of Americans do not experience unnecessary deaths due to HPV-related cancers.
Terms: <Address><Adolescent><Adolescent Youth><Adoption><Advocate><Affect><Age><American><Area><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biostatistical Methods><COVID-19 affected><COVID-19 consequence><COVID-19 effect><COVID-19 impact><COVID-19 impacted><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><California><Cancer Burden><Cancers><Cervical Cancer><Cervix Cancer><Cessation of life><Clinic><Clinical><Cluster randomization trial><Cluster randomized trial><Community Health><Community Physician><Computer software><Computerized Medical Record><Conditioning Therapy><Coupled><Data><Death><Decrease disparity><Development><Development Plans><Dissemination and Implementation><Dose><Electronic Medical Record><Ensure><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Evidence based intervention><Feedback><Free Will><Goals><HPV><HPV Vaccination><HPV Vaccine><HPV induced cancer><HPV malignancy><HPV vaccination acceptability><HPV vaccination acceptance><HPV vaccination confidence><HPV vaccination uptake><HPV vaccine acceptability><HPV vaccine acceptance><HPV vaccine confidence><HPV vaccine uptake><HPV+ cancer><HPV-Related Malignancy><HPV-associated cancer><HPV-associated malignancy><HPV-related cancer><Health Care Systems><Healthcare Systems><Herd Immunity><Human Papilloma Virus><Human Papilloma Virus Vaccination><Human Papilloma Virus Vaccine><Human Papilloma Virus-Related Malignancy><Human Papilloma Virus-Related Malignant Neoplasm><Human Papilloma Virus-associated cancer><Human Papilloma Virus-associated malignancy><Human Papilloma Virus-related cancer><Human Papillomavirus><Human Papillomavirus Vaccination><Human papillomavirus Vaccine><Human papillomavirus cancer><Human papillomavirus induced cancer><Human papillomavirus malignancy><Human papillomavirus-Related Malignancy><Human papillomavirus-Related Malignant Neoplasm><Immunization><Infectious Human Wart Virus><Influentials><Integrative Therapy><Integrative Treatment><Integrative intervention><Intervention><Intervention Strategies><Intervention Studies><Interview><Investigators><K01 Award><K01 Mechanism><K01 Program><Knowledge><Literature><Lower disparity><Malignant Cervical Neoplasm><Malignant Cervical Tumor><Malignant Neoplasm of the Cervix><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Cervix><Malignant Tumor of the Cervix Uteri><Malignant Uterine Cervix Neoplasm><Malignant Uterine Cervix Tumor><Malignant neoplasm of cervix uteri><Mentored Research Scientist Development Award><Mentored Training Award><Mentors><Mentorship><Methods><Mission><Morbidity><Morbidity - disease rate><National Cancer Burden><Outcome><Parents><Patients><Persons><Phase><Population><Preventative health care><Preventative healthcare><Preventative strategy><Prevention strategy><Preventive health care><Preventive healthcare><Preventive strategy><Primary Care><Primary Prevention><Program Development><Provider><Public Health><Race><Races><Racial Group><Randomized, Controlled Trials><Recommendation><Reporting><Research><Research Personnel><Research Scientist Development Award><Researchers><Review Literature><Secure><Series><Site><Software><Structure><Survey Instrument><Surveys><Techniques><Teen><Teenagers><Testing><Training><United States><Universities><Uterine Cervix Cancer><Vaccination><Vaccines><Virus><Youth><Youth 10-21><accept HPV vaccination><accept HPV vaccine><accept human papilloma virus vaccination><accept human papilloma virus vaccine><adolescent patient><aged><ages><arm><assess effectiveness><behavior intervention><behavioral intervention><boys><cancer disparity><cancer health disparity><cancer prevention><cancer-related health disparity><care as usual><career><career development><community-based health><coronavirus disease 2019 consequence><coronavirus disease 2019 effect><coronavirus disease 2019 impact><coronavirus disease 2019 pandemic consequence><coronavirus disease 2019 pandemic impact><coronavirus disease-19 impact><determine effectiveness><developmental><disparities in race><disparity due to race><disparity in cancer><disparity in ethnic><disparity reduction><dissemination science><effectiveness assessment><effectiveness evaluation><effects following the COVID-19 pandemic><ethnic based disparity><ethnic disadvantage><ethnic disparity><ethnic inequality><ethnic inequity><ethnic minority><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><ethnic subgroup><ethnicity disparity><ethnicity group><evaluate effectiveness><examine effectiveness><experience><girls><group of color><health care service><healthcare service><human papilloma virus vaccination acceptability><human papilloma virus vaccination acceptance><human papilloma virus vaccination confidence><human papilloma virus vaccination uptake><human papilloma virus vaccine acceptability><human papilloma virus vaccine acceptance><human papilloma virus vaccine confidence><human papilloma virus vaccine uptake><human papillomavirus associated malignancy><human papillomavirus-associated cancer><human papillomavirus-related cancer><impact of the SARS-CoV-2 pandemic><implementation intervention><implementation research><implementation science><implementation strategy><improved><individual of color><inequality due to race><inequity due to race><intervention research><interventional research><interventional strategy><interventional study><interventions research><juvenile><juvenile human><malignancy><mitigate disparity><mortality><multidisciplinary><neoplasm/cancer><next generation><parent><people of color><person of color><population of color><prevent><preventing><primary care team><primary outcome><professor><programs><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racial population><racial subgroup><racially unequal><randomized control trial><recruit><reduce disparity><reduction in disparity><research study><skills><strategies for implementation><systematic review><teen years><teenage><treatment as usual><trial design><uptake><usual care><validation studies><wart virus>