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Principal Investigator: Jessie Sellers Gibson
Organization: UNIVERSITY OF VIRGINIA
Fiscal Year: 2024
Award: $152,517
Funding agency: National Institute of Nursing Research
PROJECT SUMMARY: The proposed K23 award will prepare Dr. Jessie Gibson, PhD, RN, AGPCNP-BC to
become an independent investigator developing interventions for neuropsychiatric symptom management in
neurodegenerative disease. Dr. Gibson’s clinical and research experiences have provided a foundation in
identification, measurement, and effects of neuropsychiatric symptoms in Huntington’s disease (HD) and
Parkinson’s disease (PD). The proposed research plan will prepare Dr. Gibson to take the next steps toward
investigating treatment for these symptoms in independent clinical trials. Anxiety symptoms are extremely
prevalent in HD and PD, causing significant burden for patients and caregivers. Unfortunately, there is limited
evidence for how to treat these symptoms. Experts recommend use of psychological interventions to treat
anxiety symptoms in HD and PD, but there have been few rigorous studies to support these recommendations.
Cognitive bias modification for interpretation bias (CBM-I) paradigms address negative interpretation biases by
training participants to (re)interpret ambiguous, potentially threatening situations in more benign ways to make
anxious thinking more flexible. Our preliminary work has demonstrated feasibility of web-based CBM-I in this
population and identified the need to adapt CBM-I programs to meet the needs of individuals with movement
disorders. Our current objective is to determine whether a web-based cognitive bias modification for
interpretation bias (CBM-I) intervention can reduce anxiety in PD and HD. Thus, we aim to: 1) gather
stakeholder perspectives and 2) develop a web-based CBM-I intervention tailored to individuals with
neurodegenerative movement disorders (MindTrails-Movement), then 3) evaluate target engagement and
preliminary efficacy of MindTrails-Movement for reducing interpretation bias and anxiety symptoms in HD and
PD. To carry out these aims and prepare Dr. Gibson to become a national leader in developing interventions
for neuropsychiatric symptom management in neurodegenerative disease, she will work with an expert
mentoring team led by Dr. Bethany Teachman, and including co-mentors Drs. Madaline Harrison, Carol
Manning, Jeanne Alhusen, and Guofen Yan. Training experiences will support Dr. Gibson’s career
development goals to: 1) cultivate skills to develop behavioral interventions using human-centered design; 2)
develop expertise in clinical trial design and implementation; 3) establish advanced knowledge of mechanisms
that maintain mood and anxiety disorders; and 4) develop leadership and grantsmanship skills and establish
collaborations to prepare for a successful career as an independent nurse scientist. University of Virginia
provides the ideal environment to achieve these research and career development goals, as home to a world-
class nursing school, Huntington’s Disease Center of Excellence, American Parkinson’s Disease Association
Advanced Center for Research, and the Program for Anxiety, Cognition and Treatment (PACT) lab- all of which
are critical to the success of this proposal.
Terms: <21+ years old><Abnormal gait><Active Follow-up><Address><Adult><Adult Human><Affective Disorders><American><Anxiety><Anxiety Disorders><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Benign><Breathing><Burden on their caregivers><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Care Givers><Caregiver Burden><Caregivers><Case Series><Clinical><Clinical Trials><Clinical Trials Design><Cognition><Cognition Therapy><Cognitive><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Collaborations><Communities><Conditioning Therapy><Data><Degenerative Neurologic Disorders><Development><Development and Research><Diagnosis><Doctor of Philosophy><Drugs><Dyskinesia Syndromes><Environment><Evaluation><Evidence based treatment><FDA approved><Feedback><Foundations><Gait abnormality><Gait disorder><Gait disturbances><Gait dysfunction><Gait impairment><Goals><Home><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Individual><Intervention><Intervention Strategies><Interview><Investigators><K23 Award><K23 Mechanism><K23 Program><Knowledge><Leadership><Measurement><Medication><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Methods><Modification><Mood Disorders><Movement><Movement Disorder Syndromes><Movement Disorders><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Nurse Training Schools><Nurses><Nursing Schools><On-Line Systems><Online Systems><Paralysis Agitans><Parkinson><Parkinson Disease><Participant><Patient Recruitments><Patients><Persons><Ph.D.><PhD><Pharmaceutical Preparations><Phase><Physical activity><Population><Prevalence><Primary Parkinsonism><Process><Protocol><Protocols documentation><Provider><QOL><Quality of life><R & D><R&D><Recommendation><Research><Research Personnel><Researchers><Respiratory Aspiration><Respiratory Inspiration><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Scientist><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Strategic Planning><Subgroup><Symptoms><Testing><Thinking><Time><Training><Training Programs><Transportation><Universities><Virginia><Waiting Lists><Walking impairment><Work><active followup><adulthood><anxiety reduction><anxiety symptoms><anxious><anxious symptom><behavior intervention><behavioral intervention><body movement><burden in caregivers><burden of their caregivers><burden on caregivers><career><career development><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive training><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><develop therapy><developmental><digital><drug/agent><experience><flexibility><flexible><follow up><follow-up><followed up><followup><functional status><homes><human centered design><ideation><improved><improved outcome><innovative technologies><inspiration><internet based delivery><internet delivered><internet delivery><intervention development><interventional strategy><manage symptom><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal degeneration><neuropsychiatric symptom><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><nurse><off-label application><off-label prescribing><off-label use><online computer><participant recruitment><perceived anxiety><programs><prototype><psychologic><psychological><recruit><research and development><self-reported anxiety><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex><skills><stakeholder insights><stakeholder perspectives><success><symptom management><symptom treatment><symptomatic treatment><therapy development><thoughts><trait><treat symptom><treatment development><waitlist><web based>