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9873 documents

Determining factors of transmission and evolution of SARS-CoV-2 in populations at risk

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Elodie Ghedin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $180,957 — The major aspects of this project involve characterizing SARS-CoV-2 genetic diversity and microbial communities in the respiratory tract during infection. This involves analyzing samples from COVID-19 positive subjects, and from model animal infections. As part of this project we tackle different ty…

Development and Production of SARS-CoV2 Biologicals and Vaccines

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Jason Gall · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $5,062,451 — Coronavirus vaccines and protein reagents will be developed at the VPP. The vaccines may be manufactured through the VCMP for human clinical trials in compliance with current Good Manufacturing Practices (cGMP) and released for use in human clinical trials in healthy human volunteers. These vaccines…

Chemosensation and COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Paule Joseph · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · 2023 · $66,766 — We wrote our clinical protocol for submission to IRB soon. However, through collaborations with other investigators both intramural and extramural we have published a number of manuscripts regarding this topic. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest t…

COVID-19 Instrumentation in the RTB

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

James Cherry · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $297,252 — The project particularly aims to use state of the art instrumentation to support the needs for COVID19 research involving flow cytometry. Increasing number of NIH investigators are transitioning to complex assays for cell analysis. However, sorters currently lack the ability to translate these pan…

Technologies and Resources for Core Laboratories

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Laura F. Gibson · WEST VIRGINIA UNIVERSITY · 2023 · $179,050 — The Technology and Resources for Core Laboratories Core (Technology Core) of the West Virginia Clinical and Translational Science Institute (WVCTSI) supports research infrastructure critical for rapid translation of innovation to positively impact the health of West Virginians. Importantly, the Tech…

Factors Responsible for the Development of Post-Acute Sequelae of Acute COVID Infection (PASC) In Hawaii

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Gehan Devendra · UNIVERSITY OF HAWAII AT MANOA · 2023 · $462,752 — PROJECT SUMMARY/ABSTRACT Nearly one third of individuals who recover from acute COVID-19 will have chronic symptoms, so called ‘Post- Acute Sequelae of SARS-CoV-2’ infection (PASC). Among individuals with PASC, pulmonary complications such as persistent dyspnea and chronic cough are common. Although…

Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

JOHN P. KIRWAN · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2023 · $464,363 — Project Summary: Administrative Core The LA CaTS Center Administrative Core has been set up to promote, support, and continually evolve the governance and administrative structure of the Center, to effectively facilitate the necessary leadership, tools and processes required to integrate and align …

Core 3: Biocontainment Research Support Services Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Colin S. Duckett · DUKE UNIVERSITY · 2023 · $1,029,538 — ABSTRACT- Biocontainment Research Support Services Core (Core 3) The central mission of the Duke RBL is to support the basic and translational research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense. Support through this award will allow us to…

Addressing community-level influences of HIV and COVID-19 disparities among people with HIV

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Diana Montserrat Sheehan · FLORIDA INTERNATIONAL UNIVERSITY · 2023 · $393,365 — FIU-RCMI Research Project #3 Abstract The twin pandemics of human immunodeficiency virus (HIV) and COVID-19 share uncanny similarities with respect to racial/ethnic and socioeconomic disparities in both incidence and mortality. Structural strategies for HIV and COVID-19 outcomes could augment curren…

BSL-3 Practices Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

JEFFREY Joseph ADAMOVICZ · UNIVERSITY OF MISSOURI-COLUMBIA · 2023 · $768,114 — Project Summary Core 2: Biosafety Level 3 Practices The Biosafety Level 3 Practices Core (BPC) at the Laboratory of Infectious Disease Research (LIDR) includes three major components: Biosafety and emergency planning, user training and competency oversight, and select agent program management. The …

IND-Enabling Development of a Small Molecule COVID Therapeutic

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Ryan P Bennett · OYAGEN, INC. · 2023 · $300,000 — The proposed Phase I SBIR will conduct IND-enabling studies to establish the pharmacokinetics (PK) and SARS-CoV-2 (CoV-2) antiviral efficacy of sangivamycin (Sang) in Golden Syrian hamsters. Sang is an adenosine nucleoside analog that we discovered to be a potent, dose- dependent inhibitor of CoV-2 …

The Southwest National Primate Research Center

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Larry S. Schlesinger · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2023 · $7,483,557 — OVERALL ABSTRACT The Mission of the Southwest National Primate Research Center (SNPRC) is to improve the health of our global community through innovative biomedical research with nonhuman primates (NHPs). One way that it achieves this goal is by serving as a global resource to scientists that ca…

A biophysical assay targeting SARS CoV-2 RNA

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

sandra Paige story · NUBAD, LLC · 2023 · $298,689 — PROJECT SUMMARY The world is immersed in a health crisis rivaled only by the Spanish flu pandemic of 1918-1919. The difference between the crisis of today and the crisis a century ago is that we have advanced communication technology greatly so that huge populations of people around the globe are aw…

Enteric Pathogen Force of Infection among Children using Serology

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Benjamin F Arnold · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $720,625 — Enteric pathogen infections are a leading cause of the global disease burden, with the largest burden among children in low-resource settings. Stool-based PCR methods have dramatically improved our ability to measure enteric infections, but the challenge of collecting stool and need for near-continu…

The effect of HIV on SARS-CoV-2 transmission and emergence of variants of concern

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Chawangwa Modongo · UNIVERSITY OF CALIFORNIA-IRVINE · 2023 · $559,720 — Project Summary The emergence and spread of SARS-CoV-2 variants of concern is threatening global health and our ability to prevent COVID-19 disease, raising concerns about a potential new wave of the pandemic. HIV may complicate the trajectory of the COVID-19 pandemic and efforts to eradicate the vi…

Neurocognitive & neuropsychiatric impact of chemosensory alterations: Implications of olfactory dysfunction in COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Jonathan B Overdevest · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2023 · $178,610 — PROJECT SUMMARY Smell loss is a common neurosensory disability accompanying infection with SARS-CoV-2 novel coronavirus. The frequency and persistence of alteration in the ability to smell, or olfactory dysfunction (OD), observed during the COVID-19 pandemic highlight a knowledge gap, where risk fac…

StEP OUT

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Michelle Weiss Katzow · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2023 · $192,266 — PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award (K23) proposal will address an urgent need to advance the science of child obesity prevention in low-income, minority communities, a priority of the National Heart, Lung, and Blood Institute. Simultaneously, it…

Global Health Research and Training in Cardiovascular Disease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Margaret Leighton McNairy · WEILL MEDICAL COLL OF CORNELL UNIV · 2023 · $124,224 — ABSTRACT: The goals of this K24 proposal are to train clinical investigators in the conduct of patient-oriented cardiovascular disease (CVD) research primarily in Haiti, with a new project in Tanzania and to conduct a new study on environmental lead exposure and CVD risk factors in Haiti (Aim 1). Th…

2023 Chemical and Biological Defense GRC & GRS

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

CATHERINE S. BRANDA · GORDON RESEARCH CONFERENCES · 2023 · $6,000 — Project Summary/Abstract: This application solicits 20k from NIAID to support the registration of 20 early career scientists to attend the 2023 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Chemical and Biological Defense: Novel Applications of Science and Technology to Addre…

COVID-19 Pandemic Mitigation, Community Economic and Social Vulnerability, and Opioid Use Disorder

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

MEREDITH C. B. ADAMS · UNIVERSITY OF ROCHESTER · 2023 · $714,815 — PROJECT SUMMARY Opioid use disorder (OUD) is a serious national crisis that affects public health and economic welfare, even prior to the COVID-19 pandemic. The COVID-19 pandemic and the mitigation policies to prevent the spread of SARS-CoV-2 upended social networks, healthcare access, led to histor…