Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Thomas Quinn · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $78,215 — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), emerged as a global pandemic in early 2020. By the end August of 2023, over 770 million cases of SARS-CoV-2 have been confirmed, spanning all countries and accounting more than 6…
Susan Moir · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $327,723 — In 2023, we conducted and contributed to several clinical research studies on COVID-19. We evaluated antibody and B-cell responses following infection and/or vaccination and contributed to the analysis of innate responses in patients hospitalized with COVID-19. Our efforts focused on three types of …
MIGUEL HOLMGREN · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2023 · $1,616,783 — Calcium ions increase the open probability of the large conductance potassium (BK) channels by binding to high affinity sites within the large cytosolic Ca2+ sensing structure called the gating ring. This Ca2+ sensing structure is formed by eight Regulator of K+ Conductance (RCK) domains, two from e…
Dima A Hammoud · CLINICAL CENTER · 2023 — Progress: HIV project: We are in the stage of optimizing our animal model of Gp120 expressing HEK293 tumors implanted in nude mice in comparison to wild type tumors. We have validated and labeled multiple nanobodies against GP120 with 18F and started PET imaging. Early results are encouraging and we…
NEAL DAVID EPSTEIN · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2023 · $581,291 — Endosymbionts are unicellular organisms that reside inside the cells of a host organism and can have dramatic influence over the host, ranging from nutritional provisioning to immune function and in the case of filarial nematodes, their actual development. It is estimated that more than 75% of inse…
Peter D Kwong · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,212,339 — Based on our understanding of spike- or envelope-based mechanisms of humoral evasion, we are working to design envelope-based immunogens with these evading mechanisms disabled. Such modified immunogens with weakened defenses may elicit more broadly neutralizing antibodies. We have also devised prote…
ROBERT A SEDER · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $332,304 — Over the past year we have focused on how mucosal vaccination influences immunity and protection against Omicron variants of concerned compared to conventional mRNA boosting. For these studies, NHP are immunized with mRNA 1273 as the standard primary vaccine and then boosted several months later wit…
T. Michael Redmond · NATIONAL EYE INSTITUTE · 2023 · $404,162 — Novel coronavirus SARS-CoV-2, originating at the end of 2019 in Wuhan, China, causes the pandemic coronavirus disease COVID-19 that has had a major public health and economic impact in the USA and the rest of the world since then. The disease is quite heterogeneous and targets internal organs with m…
KATHERINE D MCREYNOLDS · CALIFORNIA STATE UNIVERSITY SACRAMENTO · 2023 · $106,500 — PROJECT SUMMARY/ABSTRACT The current COVID-19 pandemic has resulted in millions of infections and over 2 million deaths worldwide since SARS-CoV-2 emerged in Wuhan, China in December of 2019. This pandemic has revealed a significant treatment gap in the ability to minimize the morbidity and mortali…
Haichao Wang · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2023 · $418,750 — PROJECT SUMMARY Microbial infections annually claim hundreds of thousands of victims in the U.S. alone, but its complex pathogenesis is still poorly understood. Our seminal discovery of HMGB1 as a late mediator of lethal endotoxemia (Science, 1999, Cited >4,000 times) has fueled continuous search fo…
Veronica Villanueva · RUSH UNIVERSITY MEDICAL CENTER · 2023 · $22,422 — Lupus nephritis (LN) and coronavirus disease 2019 (COVID-19) both display myeloid cell dysfunction which can lead to altered signaling resulting in tissue damage, such as kidney injury. Up to 50% of LN patients develop chronic kidney disease (CKD) and 25% of COVID-19 patients are reported to experie…
Maria Antoninova NINOVA · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2023 · $388,750 — Project Summary Transposable elements (TEs) are mobile genetic elements that can propagate within the host DNA and have a significant impact on the genome organization and function. TEs are ubiquitous across the tree of life and occupy substantial fractions of animal genomes - about 20% of the D. m…
Leonid B. Margolis · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2023 · $1,895,506 — 1. Cytokines in HIV disease We followed longitudinally 90 people living with HIV (PWH) (59 women and 31 men) already virally suppressed and on antiretroviral therapy (ART) on average for 6 years. We measured the concentrations of 41 cytokines in their blood plasma and followed their trajectory over…
Michael Grigg · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $454,297 — Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the etiologic agent of COVID-19, emerged in 2019 as a public health emergency and global pandemic. SARS-CoV-2 is a linear, non-segmented, capped, polyadenylated positive-sense, single stranded RNA virus related to SARS-CoV and MERS-CoV, t…
Dax A Hoffman · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2023 · $2,031,130 — Kv4.2 complex regulation and its role in cognitive flexibility We have recently identified a novel molecular cascade that regulates the potassium channel Kv4.2 association with the auxiliary subunit DPP6 and membrane surface expression neurons. This cascade is initiated by various patterns of acti…
Heather Kalish · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2023 · $789,255 — Sub-project #1 MALDI imaging of tissue samples to identify novel proteins MALDI-TOF Imaging is an emerging tool for the label free measurement of peptides, proteins, lipids, drugs and metabolites. The tissue can be imaged directly be the MALDI-TOF and combined with other modalities to study the mo…
Mario Borgnia · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $487,097 — We have established high-throughput structure determination workflows using single particle analysis cryo-EM (SPA) on variants of the SARS-CoV-2 S protein ectodomain. These workflows allow us to solve the structure of macromolecular complexes of the spike at near atomic resolution with less than 24 …
Robert Petrovich · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $1,405,912 — The protein expression facility (PEF) functions as a support group for the principal investigators at the NIEHS. Our focus is to provide the research groups with a means to generate the proteins they require so that they can perform their experiments. These projects range from generating enough o…
JERREL L YAKEL · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $1,741,729 — The Viral Vector Core facility currently offers support for production, purification, titering, and validation of twelve types of viruses: Adenovirus, Adenoassociated virus (AAV), coronaviruses (229E, OC43, NL63, and MHV), Herpes Simplex Virus (HSV), Influenza A, lentiviruses including human immunod…
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2023 · $290,927 — During the pandemic, Dr Ho has evaluated the challenges for developing antibody therapeutics targeting SARS-Cov-2 and wrote a review/perspective article [Ho Antibody Therapeutics 2020; PMID: 32566896]. SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angiotensin-convert…