Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Joshua Hoong Yu Tan · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $444,049 — The overarching goal of this project is to study the immune response to COVID-19 at the monoclonal level to increase our understanding of basic biology and develop new tools to combat disease. We have screened plasma from >100 acutely infected and convalescent COVID-19 individuals for neutralization…
Charles M Rice · ROCKEFELLER UNIVERSITY · 2022 · $1,454,501 — Project Summary – BSL3 Virology and Animal Models Core The COVID-19 pandemic has disrupted all aspects of society across the globe. The overarching theme of this P01 proposal is to study immune responses to infection with SARS-CoV-2 and their reactivity against other coronaviruses (CoVs) such that i…
Paul D. Bieniasz · ROCKEFELLER UNIVERSITY · 2022 · $1,454,501 — ABSTRACT-PROJECT 2 The SARS-CoV-2 pandemic has established beyond doubt that animal coronaviruses are a major potential threat to human health. Although vaccines and antibodies to prevent and treat SARS-CoV-2 infection have been developed at unprecedented speed, the recurrent emergence of coronavir…
alexander wlodawer · DIVISION OF BASIC SCIENCES - NCI · 2022 · $287,390 — Recently, angiotensin-converting enzyme 2 (ACE2) was shown to be a functional receptor for SARS-CoV-2, enabling the virus to enter host target cells. Using structure-based rational design, a chimeric ACE2 peptide was designed by us for use as a ligand for analytical quantitation of SA…
Christian Mayer · DIVISION OF BASIC SCIENCES - NCI · 2022 · $9,313 — This research was primarily carried out by the cooperating laboratories. One study characterized several monoclonal antibodies targeting distinct epitopes on the SARS-CoV2 spike protein. One especially potent antibody, XG014, was capable of neutralizing SARS-CoV2 as well as its varian…
Clare Michal Waterman · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $1,014,816 — Project: MARK2/Par1b regulates cytoskeleton polarization and directed cell migration through modulation of Myosin II contractility and focal adhesion organization. Personnel: Ana Pasapera Collaborators: Sarah Heissler, Masumi Eto Goal: We sought to test the hypothesis that MARK2 mediates polariza…
vineet n kewalramani · DIVISION OF BASIC SCIENCES - NCI · 2022 · $395,790 — Using lentiviral vectors pseudotyped with SARS-CoV-2 Spike protein, we are examining different SARS-CoV-2 variants for their ability to interact with CLEC4M, and whether this interaction facilitates direct infection of cells or efficient transfer and infection of cells expressing cano…
Nadya Tarasova · DIVISION OF BASIC SCIENCES - NCI · 2022 · $22,698 — The reliability, and consequently success of virtual screening depends heavily on the accuracy of the x-ray structure depiction of the target protein structure in solution. Crystal packing can distort conformation of flexible parts of the protein thus leading to misrepresentation of t…
BALI PULENDRAN · UNIVERSITY OF WASHINGTON · 2022 · $1,377,304 — PROJECT SUMMARY– PROJECT 3: Mechanistic studies and comparisons of vaccines in preclinical models The two primary goals of the Project are to: (i) define the immunological parameters (i.e., CD4+ T cell help; innate immune response) that regulate the breadth of the antibody response in mechanistic st…
JEFFREY S GLENN · STANFORD UNIVERSITY · 2022 · $8,915,196 — ABSTRACT: Our overall objective is to develop a novel class of outpatient therapeutics targeting highly- conserved RNA structures in the genomes of SARS-CoV-2 and other respiratory viruses of pandemic potential. Using influenza A virus (IAV) as a proof-of-concept, we previously showed that: 1) addin…
SABRA L. KLEIN · JOHNS HOPKINS UNIVERSITY · 2022 · $432,172 — Research Project 3 Summary There are insufficient data regarding the long-term humoral immune responses induced after SARS-CoV-2 infection. Our preliminary data indicate that there is variation in the magnitude and duration of antibody responses following SARS-CoV-2 infection. While IgG and IgA anti…
Neil King · UNIVERSITY OF WASHINGTON · 2022 · $792,967 — PROJECT SUMMARY – PROJECT 2: Structure-based antigen and nanoparticle vaccine design Project 2 is focused on the design, production, and characterization of novel stabilized antigens and broadly protective nanoparticle vaccines. In Aim 1, we will establish automated computational pipelines that iden…
Daniel Kulp · WISTAR INSTITUTE · 2022 · $1,244,471 — Project Summary The first project of our pan-CoV proposal is titled ‘Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites’. Our team’s expertise will culminate in structurally guided coronavirus nanoparticle vaccines to broaden CoV vaccine protection. This proposal …
Gabriela Cristina Brailoiu · TEMPLE UNIV OF THE COMMONWEALTH · 2022 · $493,148 — SARS-CoV-2, the virus that causes COVID-10, impacts multiple organ systems including the central nervous system. Neurological symptoms are seen in about one third of COVID-19 patients and the virus has been found in brain tissue. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) located on cell…
JOHN S. LAZO · KEVIRX INC. · 2022 · $6,500 — The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SAR-CoV-2, like other coronaviruses, infects human airways and enters cells via its S (Spike) protein, which binds to the human angiotensin-converting enzyme 2 (ACE2) and is primed by the…
HAFIZ AHMED · GLYCOMANTRA, INC. · 2022 · $300,000 — Project Summary/Abstract The COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is a global pandemic with catastrophic consequences for healthcare systems and populations. The increased morbidity and mortality in older persons and those with diabetes (12-22%) and h…
Paras Patel · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2022 · $15,534 — PROJECT SUMMARY Understanding how different regions of the central nervous system (CNS) are affected by genetic insults is critical to advancing the study of CNS pathologies which present a major public health burden in the United States. The cerebellum and optic nerve are two such regions that are …
Santimukul Santra · PITTSBURG STATE UNIVERSITY · 2022 · $76,946 — Program Director/Principal Investigator: Santra, Santimukul PROJECT SUMMARY/ABSTRACT This application proposes to develop liposome-coated iron oxide nanosensors (LIONs) mimicking as magnetically-labeled host membranes to detect fusion interactions of enveloped viruses. Spin-spin T2 relaxation techn…
WALTHER H MOTHES · YALE UNIVERSITY · 2022 · $828,211 — Summary The COVID19 pandemic may take 1-3 years and only fully subside once we reach herd immunity. Given the high mortality of COVID19, it is of critical importance to reach herd immunity through a vaccine. The viral spike glycoprotein (S) is central to our efforts for developing an effective vacci…
JEFFREY J DESTEFANO · UNIV OF MARYLAND, COLLEGE PARK · 2022 · $193,125 — The impact of SARS-CoV-2 on public health and the global economy cannot be overstated. As of September 28, 2020, 33,224,222 cases and 999,298 deaths worldwide have been linked to this emergent virus. This staggering number continues to grow, with the United States baring disproportionately high rate…