Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Frank J Raucci · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $148,214 — PROJECT SUMMARY Cardiovascular disease is the primary cause of death for patients with Duchenne muscular dystrophy (DMD). Arrhythmia and cardiac fibrosis leading to dilated cardiomyopathy are the primary mechanisms of cardiac mortality. Pannexins (Pxs), which are large conductance ion and small mole…
Melissa Mugambi · UNIVERSITY OF WASHINGTON · 2024 · $137,672 — PROJECT SUMMARY: Pregnant women in high HIV-burden settings such as western Kenya are at increased risk of acquiring HIV infection during pregnancy. The World Health Organization (WHO) and Ministry of Health in Kenya recommend a comprehensive HIV prevention package for pregnant women in high HIV-bur…
Yisong Wan · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $382,837 — Project Summary: Multiple sclerosis (MS) is a debilitating autoimmune neuroinflammation disease inflicting millions of people worldwide. It is caused by dysregulated adaptive and innate immunity. CD4 T cells critically contribute to MS development in humans and EAE development in mice. Particularly…
Kathleen Engelman · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $621,016 — Project Summary – Overall Nonhuman primates (NHPs) have historically served as crucial animal models for diseases, and for testing of new therapies and vaccines that cannot be evaluated in small animal models. The utility of NHP models in research has been enhanced considerably by the use of immune…
John T. West · LSU HEALTH SCIENCES CENTER · 2024 · $528,369 — PROJECT SUMMARY Epidemic Kaposi’s sarcoma (KS) is an HIV-1 associated tumor, and remains one of the highest incidence neoplasms in sub-Saharan African men and women despite effective antiretroviral therapy (ART) programs. The fundamental mechanism driving KS appears to be KSHV infection, but it is c…
Melanie A Ruffner · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $185,328 — PROJECT SUMMARY The proposed research explores the mechanisms of epithelial barrier dysfunction in eosinophilic esophagitis (EoE). During its active disease phase, EoE is characterized by Th2-type, eosinophil-rich inflammation with high levels of IL-13, IL-4 and chemoattractant chemokines. There is …
TROY A HORNBERGER · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $373,868 — Project Summary / Abstract Mechanical stimuli play a major role in the regulation of skeletal muscle mass, and the maintenance of muscle mass contributes significantly to disease prevention and quality of life. Although the link between mechanical signals and the regulation of muscle mass has been r…
Priya Harakh Dedhia · OHIO STATE UNIVERSITY · 2024 · $206,689 — Adrenocortical carcinoma (ACC) is an aggressive malignancy with a poor 5-year survival rate of 6% for patients with metastatic disease. There are no targeted therapies for these patients. Unfortunately, current treatments only slow disease progression for an average of 5 months, after which drug res…
Todd C. Skaar · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $68,494 — ABSTRACT, Cancer Prevention and Control (CPC) Research Program The overall goals of the CPC Program, which are aligned with the Indiana University Simon Comprehensive Cancer Center (IUSCCC) Strategic Plan and guided by the unique needs and priorities of our catchment area, are to 1) decrease the inc…
KELVIN P. LEE · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $481,430 — ABSTRACT, Leadership, Planning, and Evaluation The Indiana University Simon Comprehensive Cancer Center (IUSCCC) has established an effective process for Leadership, Planning, and Evaluation that receives input from its senior leaders, Research Program leaders, and members as well as internal and ex…
PATRICK O. MONAHAN · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $174,429 — ABSTRACT, Biostatistics and Data Management Core (BDMC) The Biostatistics and Data Management Core (BDMC) plays a critical role in the success of cancer research at the Indiana University Simon Comprehensive Cancer Center (IUSCCC) by providing state-of-the-art biostatistical and data science support…
Jun Wan · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $69,171 — ABSTRACT, Cancer Bioinformatics Core (CBC) The Cancer Bioinformatics Core (CBC) at Indiana University Simon Comprehensive Cancer Center (IUSCCC) was established in 2015 and first received NIH/NCI CCSG support in the current grant period. Its mission is to provide the IUSCCC cancer research community…
Sara K Quinney · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $60,958 — ABSTRACT, Clinical Pharmacology Analytical Core (CPAC) The Indiana University Simon Comprehensive Cancer Center (IUSCCC) Clinical Pharmacology Analytical Core (CPAC) provides multifaceted expertise in bioanalytical methodology and clinical pharmacology to provide investigators with robust informatio…
BAOHUA ZHOU · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $83,349 — ABSTRACT, Flow Cytometry Core (FCC) The Flow Cytometry Core (FCC), formerly Flow Cytometry Resource Facility, of the Indiana University Simon Comprehensive Cancer Center (IUSCCC) supports the research efforts of IUSCCC members. Flow cytometric services are integral and critical services for the rese…
MICHAEL JONAH FINE · VETERANS HEALTH ADMINISTRATION · 2024 — The Center for Health Equity Research and Promotion (CHERP) is an HSR&D Center of Innovation representing a strong collaboration between the VA Pittsburgh Healthcare System and Corporal Michael J. Crescenz VA Medical Center and their academic affiliates, the University of Pittsburgh and the Universi…
EVE A KERR · VETERANS HEALTH ADMINISTRATION · 2024 — The Ann Arbor Center for Clinical Management Research (CCMR) has the expertise, experience, infrastructure, collaborations, and partnerships necessary to conduct cutting-edge health services and implementation research that will help Veterans receive the highest quality, safest, and most patient-cen…
Yunlong Huang · TING THERAPEUTICS, INC. · 2024 · $176,763 — CDK2 inhibitors for protecting hearing loss Ting Therapeutics LLC is a pharmaceutical company developing drugs to prevent and treat hearing loss. Cisplatin is one of the most widely used drugs to treat cancers. However cisplatin anticancer therapy causes high frequency hearing loss in 40-60% of the …
Brett E Bouma · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $597,127 — PROJECT SUMMARY Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread offering patients little hope for cure (average 5-year survival rate < 15%). The U.S. Preventive Services Task Force rec…
Christopher Alan Fraker · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $390,726 — PROJECT SUMMARY The past fifty years have seen substantial advances in the field of encapsulation of insulin producing tissues for the treatment of Type 1 Diabetes Mellitus. Persistent obstacles and limitations of the current technologies have prevented translation of these results to the clinical r…
Katherine W. Bauer · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $764,139 — PROJECT SUMMARY Young children are dependent on their parents to create family environments that support healthy weight, yet many parents do not consistently parent in ways that protect their children from obesity. Further, several interventions to improve parenting as a means to address early child…