NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Katharine L McGinigle · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $116,625 — PROJECT SUMMARY This proposed study will comprehensively stage individual disease burden and mortality risk at initial diagnosis and across the course of care for patients with chronic limb threatening ischemia (CLTI). This debilitating, progressive condition is the most severe form of peripheral a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kelsey H Fisher-Wellman · EAST CAROLINA UNIVERSITY · 2024 · $95,115 — ABSTRACT Relative to matched normal tissue, recent large scale sequencing efforts indicate that colorectal cancer (CRC) tumors are specifically enriched in loss of function mutations in mitochondrial DNA (mtDNA); however, the significance and functional consequences of high mtDNA mutational burden i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
MAARTEN G LANSBERG · STANFORD UNIVERSITY · 2024 · $411,862 — PROJECT SUMMARY The Stanford Stroke Center, one of the first comprehensive multidisciplinary centers of its kind, was established in 1992 to develop new approaches to diagnose and treat stroke. The mission of the Stroke Center is to be the best comprehensive organization in the United States focused…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Amit Majithia · VA SAN DIEGO HEALTHCARE SYSTEM · 2024 — Insulin resistance is a major cause of type 2 diabetes (T2D), heart attacks, strokes and cancer. These chronic metabolic diseases disproportionately affect veterans, especially black veterans. Targeting insulin resistance by treating obesity is effective but the major clinical options, low calorie d…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jan M. Ramirez · SEATTLE CHILDREN'S HOSPITAL · 2024 · $953,628 — Project Summary The integration of brain, breathing and the heart is vital to meet the continuously changing metabolic and behavioral demands of an organism. Consequently, disorders of breathing are rarely limited to breathing disturbances and typically also include disturbances in cardiorespiratory…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Aaron Lazorwitz · YALE UNIVERSITY · 2024 · $650,150 — PROJECT SUMMARY (ABSTRACT) Combined oral contraceptive pills (COCPs), containing both an estrogen and a progestin, remain the most commonly used hormonal contraceptive method in the US, and overall, one of the most commonly prescribed medications among all women. Despite its high prevalence of use, …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Eliezer M Van Allen · DANA-FARBER CANCER INST · 2024 · $728,817 — PROJECT SUMMARY Germline pathogenic mutations and common variants have been implicated in the development of clear cell renal cell carcinoma (ccRCC). Similarly, recurrent somatic alterations are key to ccRCC pathogenesis and distinct clinical states. Combinations of germline and somatic mutations ca…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jeffrey Kuang Zou Lee · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $858,270 — Project Summary Multi-cancer detection (MCD) tests, which evaluate cell-free DNA and other biological components with a single blood draw, are a new frontier in cancer screening, particularly for cancers with no effective screening methods. Despite commercial availability, little is known about thei…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Erika Amy Tyburski · SANGUINA, LLC · 2024 · $986,670 — Anemia, characterized by low blood hemoglobin (Hgb) levels, is the world’s most common blood disorder, afflicting 1.6 billion people, with 80 million at high risk in the US alone. Due to numerous etiologies, anemia can also be chronic and potentially life-threatening. Given the severity and epidemio…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Justin Kim · DANA-FARBER CANCER INST · 2024 · $249,647 — ABSTRACT Development of covalent drugs for cancer therapy relies heavily on identifying the full spectrum of on- and off- targets within the proteome, along with the specific site of inhibitor binding to each target. Currently we cannot predict the set of targetable cysteines for a given inhibitor n…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
HSIAN-RONG TSENG · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $195,726 — PROJECT SUMMARY/ABSTRACT Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Local regional therapies, such as local ablation and transarterial chemoembolization (TACE), are the most commonly used treatment modality for HCC. Following treatment, patients u…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Chandrasekhar Nataraj · VILLANOVA UNIVERSITY · 2024 · $110,809 — Project Summary/Abstract Pediatric cardiac arrest is a serious life-threatening problem affecting more than 15,000 hospitalized children each year in the US alone. Fewer than 50% of these children survive to hospital discharge, and neurological morbidity is common among those who survive. Importantl…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Robert B. Bourret · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $263,902 — PROJECT SUMMARY Signal transduction and protein phosphorylation are vital for life. The ability to respond to stimuli is considered a key characteristic of life. Cells detect new conditions, transduce relevant information into a usable form, and execute appropriate responses. Errors in signal transd…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Anthony Suyoung Kim · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $430,583 — Project Summary/Abstract The NorCal-RCC (Regional Coordinating Center 13) leads a regional clinical trials network of centers committed to conducting high-quality clinical research to improve stroke prevention, acute stroke treatment, and recovery from stroke as part of the NIH Stroke Net clinical t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Erin Duricy · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $48,974 — Project Summary Despite the importance of math skills in daily life tasks, relatively little is known about the neural correlates of math or its interaction with language processing in the brain. Prevailing literature posits that number sense, the ability to grasp the concept of numbers, can be unde…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Leng Han · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $396,250 — Abstract important noncoding functional data Our group constructed a series of data portals for molQTLs, including data portals for expression QTLs (eQTLs), methylation QTLs (meQTLs), and splicing QTLs (sQTLs) based on a large number of cancer samples from TCGA. We demonstrated that these QTLs are a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kyle Mitchell Hocking · VOLUMETRIX, LLC · 2024 · $1,000,000 — Project Summary Volume overload (congestion) occurs in patients with heart failure (HF) and is the leading cause of hospitalization in the elderly worldwide. Unfortunately, clinical signs and symptoms; laboratory values; and existing diagnostic tools are unreliable in providing accurate assessment o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Amanda Nili · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $23,047 — Project Summary Attention deficit/hyperactivity disorder (ADHD) is a prevalent and impairing early childhood disorder that presents notable challenges to normative development and can be reliably identified starting at preschool age, with risk captured as early as toddler age when employing developm…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rehman Ali · UNIVERSITY OF ROCHESTER · 2024 · $74,284 — PROJECT SUMMARY/ABSTRACT Breast cancer is the most diagnosed cancer in women in the United States and the most commonly occurring cancer worldwide according to the World Health Organization. The primary screening method for non-palpable breast cancers is X-ray mammography, which uses ionizing radia…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Brian S J Blagg · UNIVERSITY OF NOTRE DAME · 2024 · $423,618 — Summary: Hsp90 is a molecular chaperone that is responsible for the conformational maturation of signaling proteins associated with all ten hallmarks of cancer, making it a promising target for the treatment of cancer, as multiple signaling nodes can be simultaneously derailed as a consequence of Hs…