Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Peter B Lillehoj · RICE UNIVERSITY · 2024 · $449,888 — HIV is one of the most deadly infectious diseases in the world. HIV transmission is largely driven by acutely infected individuals who are unaware of their status or those receiving antiretroviral therapy but not virally suppressed. Currently available rapid HIV tests, including fourth-generation HI…
Elizabeth C Bryda · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $1,300,192 — Abstract (Overall) The mission of the Rat Resource and Research Center (RRRC) is to provide biomedical investigators with the rat models, embryonic stem cells, related reagents, protocols, information, support and services that will facilitate their research. The RRRC serves as a unique repository b…
Michalis Agathocleous · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $346,368 — PROJECT SUMMARY: We have developed methods to profile the metabolome of hematopoietic stem cells (HSCs) and other rare cell types purified from tissues. Each hematopoietic cell type had a distinct metabolite identity. Most metabolites were enriched or depleted in specific cell types, suggesting they…
Jessica Ann Chen · UNIVERSITY OF WASHINGTON · 2024 · $621,047 — Opioid use disorder (OUD) is a common and often fatal chronic condition that can be effectively treated with medications (MOUD). Agonists (methadone, buprenorphine) are first-line treatments that reduce overdose risk. Black and Hispanic/Latinx patients are less likely to receive buprenorphine than n…
Barbara A. Han · WASHINGTON STATE UNIVERSITY · 2024 · $363,973 — PROJECT SUMMARY/ABSTRACT After the severe acute respiratory coronavirus (SARS-CoV) emerged in China in 2002, the virus was traced back to animal markets and several genetically related viruses were identified in bats. This early work into coronavirus zoonosis and the concomitant rise of next genera…
Jacob Brenner · UNIVERSITY OF PENNSYLVANIA · 2024 · $681,194 — ABSTRACT / SUMMARY Acute critical illnesses rapidly lead to severe organ damage and loss of life. These illnesses include sepsis, stroke, and acute respiratory distress syndrome (ARDS). Here we focus on ARDS, which is acute inflammation of the lungs’ air sacs, and the cause of death in COVID-19. Fo…
Iwijn De Vlaminck · CORNELL UNIVERSITY · 2024 · $203,242 — Sepsis is a deadly condition caused by a dysregulated immune response to infection which affects 700,000 patients per year in the US alone. Early and accurate diagnosis of sepsis, and infection underlying sepsis is critical to inform treatment choices and to prevent serious organ injury and death, b…
Taishi Kimura · HDT BIO CORPORATION · 2024 · $1,074,519 — PROJECT SUMMARY/ABSTRACT As evident in the ongoing “tripledemic” of severe acute respiratory syndrome-Coronavirus-2, Respiratory Syncytial virus, and Influenza virus, as well as re-emergence of enterovirus D68, virus infection is an important health threat and a huge economic burden. Multivalent RNA…
Ram Savan · UNIVERSITY OF WASHINGTON · 2024 · $632,371 — Summary In this proposal, we will explore the role of prenylation in antiviral immunity. Prenylation is a post-translational modification that renders proteins hydrophobic, thus targeting them to the endomembrane. While the role of prenylation in immunity is unclear, our preliminary data shows compe…
DJURDJICA COSS · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2024 · $226,121 — Obesity incidence is increasing worldwide with the urgent need to identify new therapeutics. Increased adiposity is associated with chronic inflammation, which can exacerbate a number of obesity-associated diseases, including COVID-19 infection and allergic disease. There are profound sex difference…
William Checkley · UNIVERSIDAD PERUANA CAYETANO HEREDIA · 2024 · $299,996 — In Latin America, about 172 million or 58% of the population, live in 366 cities comprising over 100,000 residents, all of which have ambient air pollution (AAP) levels above WHO recommended level of 10 μg/m3 annual average for PM2.5. Exposure to AAP, both short and long-term, is associated with hig…
Mitchell H Grayson · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $721,121 — Abstract Respiratory syncytial virus (RSV) infection leads to 2.1 million outpatient visits and 58,000 hospitalizations for children under 5 years of age. In those 65 years of age or older, RSV accounts for an average of 177,000 hospitalizations and 14,000 deaths annually, with similar mortality rat…
Gergana Damianova Kodjebacheva · UNIVERSITY OF MICHIGAN AT FLINT · 2024 · $468,000 — PROJECT SUMMARY/ABSTRACT Telehealth is defined as the remote provision of health care and education. Its use greatly increased as a result of the COVID-19 pandemic and is expected to continue being widely used. The problem is the lack of understanding on how to best offer telehealth to adolescents.…
Carol H Yan · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $191,873 — PROJECT SUMMARY: Persistent post-viral olfactory dysfunction (PVOD) is associated with a large spectrum of viruses with significant adverse impacts on quality of life. The molecular and cellular changes in the olfactory epithelium in cases of persistent PVOD have not been well characterized. Specif…
Mercedes Lewandrowski · HARVARD MEDICAL SCHOOL · 2024 · $36,856 — Abstract Natural killer (NK) cells are innate lymphocytes that kill tumor and virus-infected cells, independently of peptide antigens. NK cells recognize target cells through activating and inhibitory NK receptors, which interact with specific ligands on the target cell surface. The balance of activ…
Mary Kathryn Grabowski · JOHNS HOPKINS UNIVERSITY · 2024 · $578,396 — PROJECT SUMMARY Despite rollout of Universal Test-and-Treat (UTT) in Africa, HIV incidence has declined only modestly with no country on track to meet UNAIDS 2030 targets for epidemic control. Control efforts are challenged by both “hard-to-engage” HIV-positive persons who remain viremic as well as …
Megan E. Patrick · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $2,675,194 — ABSTRACT This application is for a 5-year continuation of the national longitudinal panel data collections of the Monitoring the Future (MTF) study, an ongoing epidemiological and etiological substance use research and reporting project begun in 1975 (N~120,000, 1976-2027). In addition to being a ba…
Alvin Yu · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $249,000 — PROJECT SUMMARY Viruses are infectious agents that replicate inside the living cells of an organism, and it remains critical to understand the basic molecular mechanisms that govern viral replication, as they perform numerous complex physical and chemical processes ranging from atomic-scale phenomen…
Bronwyn Mei Gunn · WASHINGTON STATE UNIVERSITY · 2024 · $183,960 — PROJECT SUMMARY Antibodies are critical mediators of immune protection against pathogens, simultaneously acting to neutralize entry and activate innate immune cells through interaction between the antibody Fc domain and Fc-receptors (FcRs) on innate immune cells. Leveraging Fc-mediated activation i…
Cici Bauer · TUFTS UNIVERSITY BOSTON · 2024 · $674,714 — Predict to Prevent: Dynamic Spatiotemporal Analyses of Opioid Overdose to Guide Pre-Emptive Public Health Responses PROJECT SUMMARY/ABSTRACT Opioid overdose (OD) fatalities have reached crisis levels in all socioeconomic and geographic communities in the US. By utilizing a first-of-its-kind statew…