Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Lauren Penney · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · 2024 — Background: The COVID-19 pandemic has had cascading impacts for families and communities. Concerns have been raised for potential negative physical and mental health consequences due to the immediate risk of COVID-19 and the secondary social and economic effects. Family caregivers may be especially …
Paule Joseph · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · 2024 · $565,575 — The Section of Sensory Science and Metabolism (SenSMet) laboratory at NINR/NIAAA conducts translational and clinical inpatient and outpatient studies. Active collaborations to investigate areas of common interest in nutrition, taste, and obesity have been undertaken. Specifically, double-blind clini…
May Michiko Okihiro · WAIANAE COAST COMPREHENSIVE HEALTH CTR · 2024 · $375,000 — ABSTRACT Similar to other indigenous people, Native Hawaiian (NH) view health and well-being holistically. These concepts are centered on lōkahi (balance) among relationships with family and community, akua (spiritual), and ʻāina (land, sea). NH communities were once thriving, sustainable ecosystems…
Eliezer Masliah · NATIONAL INSTITUTE ON AGING · 2024 · $83,018 — The MNU at the LNG is to harness the immune system to better understand the mechanisms of neurodegeneration and to develop therapies for synucleinopathies of the aging population such as DLB, PD and AD. We propose 3 Aims, the first investigating the role of innate immune responses and combinatorial …
ROBERT L DANNER · CLINICAL CENTER · 2024 — Nitric oxide (NO): NO upregulates TNFa production (J Immunol 1994; Blood 1997) through a cGMP-independent pathway (J Biol Chem 1997; J Biol Chem 1999; J Biol Chem 2003), while ROS from eNOS uncoupling upregulates TNFa (J Biol Chem 2000) through ERK1/2 (Am J Physiol 2001). NO activation of p38 MAPK s…
JOSEPH A KOVACS · CLINICAL CENTER · 2024 — At present, there are no clear guidelines as to when antiretroviral (ARV) therapy for human immunodeficiency virus (HIV) should be stopped in the setting of elevated liver enzymes. In large part, this is due to a limited understanding of the natural history of ARV-related hepatotoxicity. We have und…
T. Michael Redmond · NATIONAL EYE INSTITUTE · 2024 · $386,457 — Novel coronavirus SARS-CoV-2, originating at the end of 2019 in Wuhan, China, causes the pandemic coronavirus disease COVID-19 that has had a major public health and economic impact in the USA and the rest of the world since then. The disease is quite heterogeneous and targets internal organs with m…
Emmie De Wit · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $2,081,320 — In any given year, lower respiratory tract infections are the leading cause of infectious disease deaths worldwide, and the fifth most important cause of death overall. The emergence of SARS-CoV-2 and the resulting COVID-19 pandemic highlighted how devastating the effect of emerging respiratory viru…
Luigi Notarangelo · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $236,110 — SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease, to multi-system inflammatory syndrome in children (MIS-C) or in adults (MIS-A) that occur 3-4 weeks after acute infection. The mechanisms underlying such broad phenotypic het…
Joshua Tan · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $339,952 — The overarching goal of this project is to study the immune response to COVID-19 at the monoclonal level to increase our understanding of basic biology and develop new tools to combat disease. We have screened plasma from >100 acutely infected and convalescent COVID-19 individuals for neutralization…
Anton Simeonov · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2024 · $327,632 — Using CryoEM can provide great insight into a protein's structure and function. Proteins under 50 kDa in size are difficult to image by standard CryoEM procedures. The legobody system helps to circumvent this problem through the generation of a large, stable protein complex composed of four proteins…
CHERYL RENEE CLARK · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $2,000,000 — The All of Us Research Program is a landmark longitudinal cohort study that aims to enroll 1 million or more participants reflecting all populations of the United States and create a unique biomedical data resource that can advance precision medicine and improve health. Since 2016, the All of Us New…
Cherry M. Beasley · LUMBEE LAND DEVELOPMENT, INC. · 2024 · $608,095 — The Lumbee tribe of North Carolina is a state-recognized tribe of approximately 60,000 enrolled members, making it the largest American Indian tribe in the eastern United States and one of the largest tribes in the nation. The tribal homeland for the Lumbee tribe is situated in Robeson County, a rur…
JACK A. YANOVSKI · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2024 · $2,333,586 — Obesity and its associated comorbid conditions (1) continue to be major issues among children in the United States. We continue to examine genes involved in the leptin signaling pathway to identify gene variants impacting body composition, with the expectation that improved understanding might help …
Ralph Cammack · WABANAKI HEALTH AND WELLNESS · 2024 · $372,614 — Wabanaki ancestral lands historically provided abundant resources, allowing Wabanaki people to rely exclusively on hunting, fishing, and gathering for all their subsistence needs. However, as their sacred hunting and fishing grounds were lost to colonization, the Wabanaki people lost access to their…
Edwina Yeung · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2024 · $1,238,838 — Recruitment is ongoing at eight clinical sites located in Alabama, Louisiana, North Carolina, Pennsylvania Utah, and Virginia. We anticipate about 11,525 pregnant women with about 3,825 of their male partners to be recruited. Pregnant women are recruited in the first half of pregnancy and followed t…
Tonja Nansel · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2024 · $880,951 — Inadequate intake of whole plant foods and excessive intake of discretionary foods (foods of minimal nutritional value and high energy density) begin in early childhood. Early childhood is a critical period for the development of food preferences and eating behaviors, which in turn influence child g…
John O'Shea · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2024 · $2,543,374 — Discovery of patients with mutations of Janus kinase (JAKs) and STATs reveals new disease mechanisms and insights into pathophysiology. STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation. We i…
Peter Grayson · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2024 · $2,975,025 — Recruitment to date remains strong within the Vasculitis Natural History Study. All patients seen at the NIH Clinical Center receive comprehensive clinical evaluation and contribute samples to a growing biobank. Over the last few years, we have mainly focused on two forms of vasculitis: large vessel…
Pravitt Gourh · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2024 · $955,026 — We have established a large multi-center collaboration designated as GRASP (Genome Research in African American Scleroderma Patients), comprising 25 centers outside of the NIH, and have enrolled the largest cohort of African American scleroderma (systemic sclerosis, SSc) patients. Currently, we have…