Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Christine Anne Roden · DUKE UNIVERSITY · 2024 · $38,033 — Project Summary/Abstract: INTRODUCTION: RNA viruses such as SARS-CoV-2 represent an ongoing public health threat. To replicate properly, RNA viruses must perform multiple functions in the same cytoplasm (i.e., genome replication, circularization, generation of sub-genomic RNA, packaging etc.) and fo…
Sophie Huddart · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $174,420 — PROJECT ABSTRACT There is increasing recognition that post-tuberculosis (TB) lung disease (PTLD) is common and causes significant morbidity and mortality. However, changes in lung impairment are heterogenous with some patients improving and others worsening after completion of TB treatment. Moreover…
Sumanth Gandra · WASHINGTON UNIVERSITY · 2024 · $201,208 — Project Summary/Abstract: An antigen test for Neisseria gonorrhoeae (Ng) that is accurate, simple, scalable, non-invasive, rapid, and effective at the point-of-care (POC), would transform public health decisions. Although antigen detection rapid diagnostic tests (Ag-RDT's) for Ng are available, they…
MARTIE P Thompson · APPALACHIAN STATE UNIVERSITY · 2024 · $137,093 — Project Summary Suicide is a significant public health problem among youth. Data indicate suicidal behaviors were increasing among youth even before the COVID-19 pandemic began and have likely increased even more since its onset. This R16 proposed research seeks to address the urgent mental health c…
Faraz Choudhury · IMMUTO SCIENTIFIC, INC. · 2024 · $612,291 — Abstract Immuto Scientific Inc. is developing a robust, automated benchtop instrument to perform high-throughput structural characterization of protein biotherapeutics in a fraction of time of traditional structural characterization techniques such as x-ray crystallography and cryo-EM. Protein-based…
SHANNON Takala Harrison · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $352,643 — Vaccination has had a profound impact on human health and has eradicated or almost eradicated once feared diseases such as smallpox and polio and substantially decreased morbidity and mortality due to pneumococcus, measles and pertussis amongst many others. The utility and cost effectiveness of vacc…
Dennis A Bente · THOMAS JEFFERSON UNIVERSITY · 2024 · $788,347 — Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe disease in humans, with fatality rates reaching 40%. CCHFV is endemic to parts of Africa, Asia, the Middle East, and Europe, specifically to regions where the tick vector, species of the Hyalomma genus, is present. Classified as an NIH/NIAI…
Jacen Shannon Moore · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $256,718 — The CoVID-19 pandemic amplified the stress of existing critical shortages of allied health professionals, especially in rural communities and underserved populations. Careers including clinical laboratory sciences (CLS) and public health information technology (PHIT) are less well promoted as other …
MICHAEL B ROTHBERG · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $1,632,009 — Project Summary/Abstract For older adults, prolonged hospitalization can lead to a devastating loss of mobility and independence. Each year, 12 million adults over the age of 65 are hospitalized, and 30% are discharged to a post-acute care facility. One of the risks of hospitalization is bed rest, w…
YA HA · YALE UNIVERSITY · 2024 · $334,149 — Project Summary / Abstract The objective of the proposed research is to elucidate the biochemical mechanisms underlying the exquisite substrate binding and catalytic specificity of two phosphatidylinositol phosphate 5-kinases (PIP5K, PIKfyve). The PIPK family of lipid kinases include PIP5K (type 1),…
Jasmine Travers Altizer · NEW YORK UNIVERSITY · 2024 · $192,629 — PROJECT SUMMARY/ABSTRACT The disproportionate rise in nursing home (NH) use among Black and Latino persons living with dementia (PLWD) reflects the inadequacy of existing programs and policies to support aging in place for the most vulnerable. Enabling aging in the community and preventing avoidabl…
JULIA W FELTON · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $346,893 — Project Summary Rapid escalations in substance use during adolescence confer risk for the development of substance and alcohol use disorders across the lifespan. Thus, identifying malleable risk factors and prevention targets that emerge before substance use onset is an important public health goal.…
Tyler Steven Brown · BOSTON MEDICAL CENTER · 2024 · $193,752 — PROJECT SUMMARY Background: South Africa is a unique, high-risk environment for the emergence of novel drug-resistant strains of Mycobacterium tuberculosis (Mtb). Novel drug-resistant Mtb strains are often identified only after they have achieved sustained transmission and dispersed into larger geog…
Wei Gao · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $398,730 — PROJECT SUMMARY Metabolic syndrome is on the rise as the leading cause of morbidity and mortality, affecting more than a third of all U.S. adults. If untreated, patients who develop type 2 diabetes mellitus (T2D) are at high-risk for major adverse cardiovascular events, including stroke, myocardial …
Gabriel D Victora · ROCKEFELLER UNIVERSITY · 2024 · $812,354 — PROJECT SUMMARY Germinal centers (GCs) are the site of affinity maturation, a prototypical Darwinian process that is required to generate the potent antibodies that protect against infectious disease. Over the past decades, work by several groups, including our own, has led to a comprehensive genera…
Laila Rasmy Gindy Bekhet · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $351,000 — Abstract In the era of big clinical data, the availability of rich real-world clinical data sources (RWcD) enables the development of predictive models for different clinical events, bringing the potential to improve efficiency and lower the cost of health care. However, the currently in-use models …
Dmitri Ermolenko · UNIVERSITY OF ROCHESTER · 2024 · $594,440 — The Central Dogma of molecular biology is that DNA is used to make mRNA, which in turn is used to make proteins. Central to physiology of every live cell, translation of messenger RNA (mRNA) into protein is catalyzed by the ribosome, structurally complex and dynamic macromolecular machine. Dysregula…
Monica Cartelle Gestal · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $6,500 — SUMMARY Bordetella species are significant agents of morbidity and mortality worldwide, manifesting the life-threatening disease pertussis in humans and severe respiratory infections in animals. Despite the availability of pertussis vaccines, in the past 15 years, the World Health Organization has e…
DANIEL Joseph FRANCE · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $656,675 — PROJECT SUMMARY High provider workload is a threat to care quality, patient safety, and providers’ well-being and job satisfaction. Workload – which lacks a universally accepted definition - is a complex multi-dimensional construct that is affected by external task demands and environmental, organi…
Marulasiddappa Suresh · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $194,375 — Abstract: Respiratory infections have been among the top three leading causes of global deaths for decades. Their importance is reinforced by the emergence of novel highly transmissible respiratory pathogens, as witnessed in the current SARS-CoV-2 and past influenza pandemics. Current influenza and …