Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Emika S. Miller · OHIO STATE UNIVERSITY · 2024 · $27,508 — PROJECT SUMMARY/ABSTRACT Alzheimer’s disease and related dementias (ADRD) affect approximately 50 million [1] people worldwide, with African Americans facing an increased risk of developing this life-limiting disease characterized by the eventual loss of cognitive ability and independence. ADRD has …
Ian Bakanas · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $73,828 — Project Summary/Abstract The goal of this proposal is to elucidate biological mechanisms for proton transfer by designing function from scratch. The coupled movement of protons and electrons is crucial to biological energy transduction and central to life. While electron transfer (ET) has been exten…
Maurizio Franco Cereda · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $827,682 — PROJECT SUMMARY Acute Respiratory distress syndrome (ARDS) is a life-threatening condition caused by widespread pulmonary inflammation leading to lung injury. ARDS has a mortality that can be higher than 40% and is the main cause of death from COVID-19. Although necessary to support life, mechanical…
David Daeho Kim · UNIVERSITY OF CHICAGO · 2024 · $750,910 — ABSTRACT The increasing prevalence of diet-related chronic conditions, such as obesity, diabetes, and cardiovascular disease, has elevated the importance of improving nutrition as a national health priority. However, critical evidence remains limited on the long-term health outcomes and economic im…
Kevan C Herold · YALE UNIVERSITY · 2024 · $722,908 — Project Summary The overall objective of the work supported by this grant has been to develop therapies to treat, delay, or prevent Type 1 diabetes (T1D). The work from prior funding cycles has changed the field. The studies have included clinical and mechanistic investigations that led to the first…
Emily Happy Miller · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $199,584 — Abstract In the past decade three highly virulent human betacoronaviruses have emerged, including SARS-CoV-2 which has caused a devastating pandemic and is responsible for the deaths of over 6 million people worldwide. Current vaccines and monoclonal antibody (mAb) treatments for SARS-CoV-2 are susc…
SUZANNE SANDMEYER · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $348,723 — PROJECT SUMMARY/ABSTRACT The Genomics Research and Technology Hub (GRT Hub), the sole UCI genomics shared resource, is applying for support to purchase a Hamilton LiquidScan NGS STAR (STAR). The GRT Hub was founded in 1999 and has served the campus for microarray, DNA genomic analysis and mapping, b…
Tim Alan Ahles · CITY COLLEGE OF NEW YORK · 2024 · $1,334,500 — The CCNY-MSKCC Partnership has successfully created a mutually beneficial, cross-institutional collaboration that has emphasized research across the translational T0-T4 continuum, the creation of an education pipeline for attracting underrepresented students from diverse backgrounds to careers in ca…
Gary R Whittaker · CORNELL UNIVERSITY · 2024 · $477,146 — Project Summary / Abstract We propose to develop a novel therapeutic for respiratory viruses, including all current and predicted SARS- CoV-2 variants, other coronaviruses, influenza, and paramyxo/pneumoviruses—using a peptidomimetic small molecule approach targeting TMPRSS2 and other trypsin-like p…
Armando Gil Burgos-Rodriguez · UNIVERSITY OF PUERTO RICO MED SCIENCES · 2024 · $1,016,909 — PROJECT ABSTRACT: A storage area at the Sabana Seca Field Station is urgently needed to accommodate any colony expansion. To support any increase in housing and research activity, additional storage space becomes imperative, aligning with our commitment to the efficient and effective utilization of …
Jyoti K Jaiswal · CHILDREN'S RESEARCH INSTITUTE · 2024 · $569,440 — The leading cause of hospitalization and death in children with trisomy 21 (TS21), also known as Down syndrome (DS), is lower respiratory tract infection (LRTI). Children with DS have nine times higher risk of hospitalization and mortality due to LRTIs caused by respiratory syncytial virus (RSV). Un…
David W Gludish · CORNELL UNIVERSITY · 2024 · $235,500 — This project will credential two novel types of broadly applicable mouse models, which we will demonstrate in the lung. First, we will express genes that drive disease susceptibility on one side of the lungs only, a model we call a Unilateral Mosaic, creating disease-prone and disease resistant (int…
BARRY M WILLARDSON · BRIGHAM YOUNG UNIVERSITY · 2024 · $447,548 — PROJECT SUMMARY The COVID-19 pandemic created the greatest infectious threat to global health in 100 years, and monumental efforts have been made by the scientific community to combat the SARS-CoV- 2 virus. This proposal seeks to extend this effort by investigating a mechanism by which SARS- CoV-2 h…
Alex Joseph Guseman · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $249,000 — Project Summary/Abstract In late 2019, the SARS-CoV2 virus emerged as a global pandemic, causing the severe respiratory disease COVID-19 and resulting in millions of deaths worldwide. As a coronavirus, SARS-CoV2 host interactions are dictated through the Spike proteins that encompass the virion. The…
Andrew Zelhof · TRUSTEES OF INDIANA UNIVERSITY · 2024 · $681,125 — Project Summary: The Drosophila Genomics Resource Center (DGRC) supports the international community of scientists utilizing Drosophila melanogaster for biomedical research. The mission of the DGRC is to 1) provide broad access to genomics resources by acquiring, authenticating, archiving, curating,…
Shenglong Zhang · NEW YORK INST OF TECHNOLOGY · 2024 · $299,486 — PROJECT SUMMARY An RNA sequence with all its diverse modifications constitutes ‘true’ information content of the RNA. Defects in RNA modifications account for >100 human diseases, such as breast cancer, type-2 diabetes and obesity, affecting millions of Americans. Despite its significance, the true …
ARTHUR Leonard CAPLAN · UNIVERSITY OF GHANA · 2024 · $247,768 — Project Summary The proposed program will continue to build sustainable research ethics and integrity capacity in Ghana through a joint partnership between New York University Grossman School of Medicine (NYU GSOM) and University of Ghana School of Public Health (UG SPH). The NYU-UG Research Integri…
Mireille Kamariza · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $675,156 — Abstract Tuberculosis (TB) is second only to COVID-19 as the most lethal cause of death from a single infectious agent. In 2020, an estimated 10 million people developed TB, nearly half a million of which were infected with drug- resistant tuberculosis (DR-TB). Early detection of infection and drug …
Naomi Miriam Hamburg · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $663,087 — Project Summary/Abstract Coronavirus 2019 (COVID-19) has infected more than 29 million globally. While the majority of individuals experience mild symptoms, the presence of obesity among other factors identifies a particularly high-risk group of individuals for development of severe COVID-19. Severe…
Erich R Mackow · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $237,569 — Powassan virus (POWV) is a neurovirulent tick-borne flavivirus (FV) emerging in the N.E. US. POWV is present in tick saliva, injected into the skin during a 15-minute tick bite and causes a 10% fatal encephalitis resulting in severe long-term neurologic damage in 50% of patients. There are currently…