Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Shweta Kailasan · ABVACC, INC. · 2024 · $299,528 — There is an outbreak of Marburg virus disease (MVD), relative of Ebola virus, currently ongoing in Equatorial Guinea and Tanzania. There have been multiple, deadly outbreaks of MVD in the past with ~88% lethality. There are currently no approved vaccines or therapeutics for MVD and very few in clini…
Thomas Carpino · JOHNS HOPKINS UNIVERSITY · 2024 · $48,974 — PROJECT SUMMARY/ABSTRACT Specific Aims: The overarching goal of this proposed study is to assess the factors associated with monkeypox (MPOX) vaccination, testing, and stigma amongst men who have sex with men (MSM) in the United States (US). Specially, we aim to 1. Evaluate determinants and disparit…
Jimi Huh · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $712,927 — ABSTRACT. Structural and social inequities have historically impacted the health and wellbeing of Black, Indigenous and Persons of Color (BIPOC) in the United States, resulting in health disparities that were exacerbated by the COVID-19 pandemic, which coincided with a surge of discriminatory events…
Louis M Mansky · UNIVERSITY OF MINNESOTA · 2024 · $193,750 — Human T-cell leukemia virus (HTLV-1) has been estimated to infect 15-20 million individuals worldwide and is known to be the etiological agent of an adult T-cell leukemia/lymphoma (ATLL), an inflammatory disease syndrome known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a…
WILLIAM C BECKER · VA CONNECTICUT HEALTHCARE SYSTEM · 2024 — Background: Evidence of risks for serious adverse outcomes and limited benefit of long-term opioid therapy (LTOT) have driven VA recommendations for LTOT tapering or discontinuation when benefits no longer outweigh harms. However, LTOT tapering may also pose risks of harm. Significance: The study ad…
Dan Theodorescu · CEDARS-SINAI MEDICAL CENTER · 2024 · $392,659 — PROJECT SUMMARY Even with immune checkpoint blockade therapy (ICBT), most patients with metastatic bladder cancer (BC) die of their disease. In the previous funding period, we studied CD24, a metastasis driver and prognostic marker. Our most translationally significant finding is induction of CD24 e…
Mariana Lazo Elizondo · DREXEL UNIVERSITY · 2024 · $1,208,123 — Latinos in the U.S. experience significant disparities in access to mental health services due to lack of health insurance, cost of services, limited awareness of mental health resources, mental health stigma, and fear of deportation. Limited English proficiency coupled with an acute lack of bilin…
Peter R Chai · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $268,500 — Project summary Emergency departments (ED) in the US have experienced a significant increase in admissions for opioid-related overdoses and suicide attempts during the COVID pandemic. Individuals with opioid use disorder (OUD) have a lifetime prevalence of suicide attempts exceeding 40%, along with …
Panagiotis Roussos · JAMES J PETERS VA MEDICAL CENTER · 2024 — PROJECT SUMMARY Precision Psychiatry is an emerging approach that considers patients’ characteristics to customize prevention and treatment for serious mental illness. The Million Veteran Program (MVP) is the largest and most comprehensive biobank in the world, currently involving multi-ancestry gen…
Barbara Ellen Jones · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2024 — Background: The COVID-19 pandemic exposed critical failures in the management of pneumonia. Pneumonia is the leading cause of death from infectious diseases, resulting in over 20,000 hospitalizations and thousands of deaths across the VA system each year. For the past thirty years, the mainstays of …
Alberto Gandini · ACCEL DIAGNOSTICS, LLC · 2024 · $398,753 — Summary In response to the COVID-19 pandemic and the increasing need of serological testing we propose the development and clinical validation of a novel serological blood test, RapidQCT™, to aid in the diagnosis and management of the COVID-19 pandemic. As the case for other viral infections, the im…
Zheng Yan · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $620,987 — Project Summary Long-term, continuous monitoring of heart electrical activities via electrocardiogram (ECG) plays a critical role in early diagnosis and timely interventions of various heart diseases. Concurrent detections of heart mechanics via seismocardiogram (SCG) can yield important data that c…
Mara Helene Buchbinder · YALE UNIVERSITY · 2024 · $579,896 — PROJECT ABSTRACT Intensive care unit (ICU) teams (i.e., nurses, physicians, and respiratory therapists) have some of the highest rates of burnout in healthcare. Burnout is an occupational phenomenon resulting from chronic workplace stress and is characterized by exhaustion, depersonalization, and re…
Nicole Jill Cook · CASE WESTERN RESERVE UNIVERSITY · 2024 · $489,904 — Long-Term Effects of COVID-19-induced Health Care Delivery Changes on Patient & Workforce Processes & Outcomes in Safety Net Practices Caring for Health Disparity Populations ABSTRACT / PROJECT SUMMARY Primary care provides more than half of all outpatient visits ― 500 million each year ― with onl…
Alison Meredith Buttenheim · UNIVERSITY OF PENNSYLVANIA · 2024 · $583,238 — PROJECT SUMMARY A safe, effective, affordable and acceptable vaccine against HIV has been an epidemic-ending goal for decades, and recent years have seen substantial progress towards developing and testing promising candidate vaccines. For highly vulnerable groups like adolescent girls and young wom…
Peng Wu · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $809,851 — PROJECT SUMMARY/ABSTRACT Regulation of the immune system is substantially influenced by glycosylation. Cell-surface glycans tune ligand-receptor binding and set a threshold for initiating the downstream signaling for immune cell activation. Siglecs (sialic acid-binding immunoglobulin-type lectins) …
Michaela Ulrike Gack · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $446,578 — RIG-I and MDA5 are key cytosolic receptors for sensing various RNA viruses, including coronaviruses, influenza virus, and flaviviruses. Upon binding of viral RNA, RIG-I-like receptors initiate signal transduction pathways that result in type-I interferon (IFN) induction to suppress viral replication…
Junichi Ishigami · JOHNS HOPKINS UNIVERSITY · 2024 · $156,551 — ABSTRACT/ PROJECT SUMMARY Dr. Junichi Ishigami, MD, MPH seeks a Mentored Research Scientist Development Award in order to obtain essential skills and mentored research experience to become an independent investigator in the field of implementation research to improve the uptake of influenza vaccinat…
Bruce W. BIRREN · BROAD INSTITUTE, INC. · 2024 · $12,121,843 — Infectious diseases remain an important global threat despite the continuing invention of drugs, vaccines, and other effective interventions. Two principal factors drive this continued threat: 1) efficacious interventions are nearly always met with rapid evolutionary responses on the part of pathoge…
GRETCHEN L HAAS · VETERANS HEALTH ADMINISTRATION · 2024 — This is a Hybrid 1, effectiveness-implementation study of yoga-based exercise (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI), defined here as schizophrenia (SZ), schizoaffective disorder (SZA) and bipolar I disorder (BP1). SMIs are common, severe and dev…