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9873 documents

Improving alcohol and substance use care access, outcomes, and equity during the reproductive years: A Type 1 Hybrid Trial in Family Planning Clinics

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

HEATHER J GOTHAM · EMORY UNIVERSITY · 2024 · $704,512 — Rates of risky alcohol and drug use and alcohol and substance use disorders (AUDs/SUDs) are highest among women during their reproductive years compared to other periods of the life course. AUDs and SUDs are associated with significant and lifelong behavioral, mental, physical, and sexual and reprod…

Making the invisible visible: An automated clinical decision support tool for Intimate Partner Violence Risk and Severity Prediction (AIRS)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Bharti Khurana · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $170,705 — Project Abstract This project is focused on developing an automated clinical decision support tool for predicting Intimate Partner Violence (IPV) risk and severity based on historical imaging and clinical data. Despite the high prevalence and urgency of this critical public health issue, there is cu…

SARS-CoV-2 correlates of protection in a Latino-origin population

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

James D Brien · UNIVERSITY OF PUERTO RICO MED SCIENCES · 2024 · $812,000 — SUMMARY/ABSTRACT Although more than four years have passed since the initial virus appearance, nowadays, most of the population has been vaccinated with multiple doses of mRNA-based vaccines and has endured multiple infection events. Still, SARS-CoV-2 continues to cause disproportionately higher mor…

Mechanisms and Duration of Immunity to SARS-CoV-2 - Supplement Application for Sept 2024-Aug 2025

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Scott Dexter Boyd · STANFORD UNIVERSITY · 2024 · $939,222 — SUMMARY The Stanford U54 SARS-CoV-2 Serological Sciences Center of Excellence (SUSS-COE) has remained true to its original goals as a member of the SeroNet consortium organized to address the urgent need for better understanding of human immune responses to the SARS-CoV-2 coronavirus in the Covid-19…

SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jacek Skarbinski · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $302,796 — Abstract Serologic testing for presence of SARS-CoV-2 antibodies is a critical tool for understanding the epidemiology and designing control strategies for the COVID-19 pandemic. Our understanding of the epidemiology of this pandemic is primarily derived from real-time data on the number of polymera…

Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH-EPICS)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

ANDREA L COX · JOHNS HOPKINS UNIVERSITY · 2024 · $759,945 — Johns Hopkins has broad expertise in the science of human health, with viral immunity, pathogenesis, epidemiology, biostatistics, and surveillance emerging as integral components of the multidisciplinary research mounted at Johns Hopkins during the current pandemic. We propose development of a Serol…

Immuno-Serological Assays for Monitoring COVID19 in Patients with Hematologic Malignancies

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Rong Fan · YALE UNIVERSITY · 2024 · $107,220 — Summary The main goals of the Supplement Award are to (1) correlate immunoserological responses to early immune reactions in local tissue environment of the vaccine injection site in healthy donors, and (2) the compare between healthy controls and patients with hematological disorders or autoimmune …

Discovery and characterization of protective Influenza Type B Virus neuraminidase antibodies

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Rachael Wolters · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $122,850 — Project Summary/Abstract Influenza causes an estimated 1 billion cases yearly, with severe cases leading to fatal bronchopneumonia, particularly in vulnerable populations. Influenza virions express two major surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA), the latter of which is of…

Structure, function, and inhibition of the SARS-CoV-2 replication-transcription complex

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

ELIZABETH A CAMPBELL · ROCKEFELLER UNIVERSITY · 2024 · $620,543 — Project Summary COVID-19, caused by the coronavirus SARS-CoV-2, continues to devastate the world. In less than a year, there have been more than 20 million cases with over 700,000 deaths. The viral RNA-dependent RNA polymerase (RdRp) is the central enzyme responsible for transcription and replicatio…

Broad-spectrum therapeutics against SARS-CoV-2 3CL protease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

ELIZABETH ANN FITZPATRICK · EMORY UNIVERSITY · 2024 · $645,603 — PROJECT SUMMARY/ABSTRACT COVID-19 was first identified in December 2019 in Wuhan, Hubei province, China, resulting in the ongoing 2019- 2020 pandemic. COVID-19 is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- 2). Common symptoms of the disease include fever, dry cough, sho…

The Effects of the Medicaid Continuous Coverage Requirement during the Public Health Emergency on Postpartum Coverage and Maternal and Infant Care after Childbirth

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Erica L Eliason · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $248,988 — PROJECT SUMMARY/ABSTRACT Career Goal: My long-time career goal is to become an independent investigator studying the effects of health care policies on access and use of maternal and infant health care services among low-income populations. With additional skills in claims data, subject matter exper…

Computational Methods for Systems Genetic Analysis of Rare Polygenic Disorder

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Sung Chun · BOSTON CHILDREN'S HOSPITAL · 2024 · $827,753 — Idiopathic Pulmonary Fibrosis (IPF) inflicts a significant healthcare burden and high rate of mortality in the U.S. Current treatment options can slow the rate of lung function decline, but the five-year survival remains low, therefore there is clear unmet medical needs for novel therapeutics. Here,…

Humoral Immune Mechanisms of Acute and Chronic Neurologic Sequelae of COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

SAMUEL JEREMY PLEASURE · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $575,015 — PROJECT SUMMARY COVID-19 is associated with a growing number of peripheral and central nervous system complications. It has become clear that a subset of these syndromes, including acute necrotizing encephalopathy, steroid- responsive encephalitis and Guillain-Barré syndrome, are likely due to dire…

Genetic, Social, and Developmental Epidemiology of Drug Use Disorders

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

KENNETH SEEDMAN KENDLER · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $589,808 — Program Director/Principal Investigator: Kendler, Kenneth S This second competitive renewal seeks to continue our innovative and productive research program which seeks to understand the etiology of drug use disorders (DUD) utilizing data available on the entire population of Sweden of unparalleled …

Strategies to Innovate EmeRgENcy Care Clinical trials Network (SIREN) Network - Pittsburgh

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Clifton W. Callaway · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $380,790 — The University of Pittsburgh site for the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) will continue its leadership as a Hub for recruiting participants into emergency care research. Advancements in acute treatment for time-sensitive and life-threatening conditions requires …

COVID-19 Vaccine Effectiveness in Pregnant Women and their Infants

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Ousseny Zerbo · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $539,708 — Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) which emerged in December 2019 and has since led to an unprecedented global pandemic with high morbidity and mortality. Current authorized vaccines against SARS-CoV-2 demo…

Long COVID Health Literacy Project: Bringing Health Information to Patients and Providers with Health Disparities in Rural Northern New England

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jeffrey Parsonnet · DARTMOUTH-HITCHCOCK CLINIC · 2024 · $150,000 — The purpose of this project is to address health disparities in the care of patients with post-acute COVID syndrome (PACS) due to the rural nature of northern New England and its shortage of medical services. We will develop useful, understandable and relatable information for patients and providers…

Evaluation of Impact of EHR Documentation Assistant Modalities on Provider and System Level Outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Vishnu Mohan · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $666,827 — Project Summary Over the past decade, there has been a growing epidemic of physician burnout, driven most notably, by Electronic Health Records (EHR), and the increasing amount of time providers spend on them. A number of solutions have been developed to untether the provider from the EHR. Prior to…

Harnessing implementation science to study stress management for correctional officers in jail settings

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Margaret Gorvine · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $132,063 — PROJECT SUMMARY The purpose of this K01 Mentored Research Scientist Career Development award is to support Dr. Margaret Gorvine's current trajectory toward independent investigator status—via achieving the study aims and training goals to extend innovative research in the arenas of implementation s…

Feasibility of Mindfulness Meditation Training and Home Practice in Persons with Spinal Cord Injury: A Pilot Study

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Radha Korupolu · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $225,005 — Project Summary: The prevalence of debilitating chronic pain in people with spinal cord injury (SCI) ranges from 65-85%. Chronic pain after SCI contributes to anxiety, depression and diminishes the health-related quality of life (QOL). Pharmacological agents such as opioids are the primary therapeut…