Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Leighton Chan · CLINICAL CENTER · 2024 — AET is generally safe, inexpensive, and can easily be made available and accessible to almost everyone. It requires no approval by regulatory agencies and is thus available as a medically prescribed and supervised intervention almost immediately following confirmation of its safety and efficacy. Six…
Steven Jacobson · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2024 · $300,000 — This project builds upon our expertise in determining if there is B and T cell clonal expansion in the cerebrospinal fluid. In the context of HIV infection this will help identify if there is an HIV reservoir in the meninges, which have a large number of macrophages and could could serve as a reserv…
Paul Taylor · NATIONAL INSTITUTE OF MENTAL HEALTH · 2024 · $2,347,803 — The principal mission of the Core is to help NIH researchers with analyses of their fMRI (brain activation mapping) and structural MRI (brain anatomy) data. Along the way, we also help non-NIH investigators, many in the USA but also some abroad. Several levels of help are provided, from short-term i…
Govind Nair · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2024 · $867,749 — - Brain segmentation algorithms: Neurological diseases can alter the brain volumes, and the core has focused on robust automated brain segmentation and volumetric methods. Machine learning based brain segmentation technique developed in-house (Classification using DErivative-based Features or C-DEF)…
Niranjana Amin · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2024 · $722,142 — The facility of NINDS Biospecimen core has been established in the newly renovated lab in 2N104, located in Bldg.10, in February of 2023. As of September 2024, the repository is storing, maintaining, and dispersing samples from over 19 different NINDS protocols, as well as collecting and processing…
Maryland Pao · NATIONAL INSTITUTE OF MENTAL HEALTH · 2024 · $7,910,164 — CLINICAL RESEARCH SUPPORT SERVICES: A central mission of the OCD is to ensure that research participants receive the highest quality clinical care. The OCD is responsible for oversight of all clinical aspects of the NIMH Intramural Research Program (NIMH IRP). The OCD, along with Scientific Director…
Christopher Arthur LeClair · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2024 · $2,962,787 — The ACC continued to navigate the logistical challenge of providing core analytical chemistry services to DPI researchers within the framework of the current hybrid work environment. To accommodate the varied onsite and telework schedules of DPI staff, ACC team members worked together to ensure the …
HAN WEN · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $1,531,012 — This project is the main effort of my lab for the last year. On the clinical application front, we further developed computed-tomography image analysis tools for two clinical protocols: 96-H-0100, LAM and other rare cystic lung diseases, PI Joel Moss, NHLBI Pulmonary Branch Lymphangioleiomyomatosi…
Nihal Altan-Bonnet · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $3,102,771 — Much of the field of virology has long viewed the cell as a passive supplier of viral building blocks and focused on how viruses exploit individual cellular enzymes for transcription of their messenger RNAs or translation of the viral proteins. Dr. Nihal Altan-Bonnet using the dynamic tools of live-…
Sean Agbor-Enoh · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $2,159,104 — Project 1: Cell-free DNA to detect acute rejection. Dr. Agbor led the creation of the Genomic Research Alliance for Transplantation (GRAfT), a consortium of five transplant centers in the DC metropolitan area and NHLBI. He is the principal investigator of the natural history study of heart and lung …
John A. Hanover · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $1,318,649 — A dynamic cycle of addition and removal of O-GlcNAc in the nucleus and cytoplasm mediates a final step in the hexosamine signaling pathway. The targets of this modification are nuclear pore complexes, transcription complexes, proteasomes and signaling kinases. Based on the targets modified by O-Glc…
Vipul Periwal · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $189,847 — Current models for inferring co-evolutionary contacts from aligned protein sequence data use the principle of maximum-entropy (ME) which assumes that the sequences are in a state of equilibrium with respect to the evolutionary forces acting on them. This has two obvious issues. Firstly, HIV protein …
DAVID SCHRUMP · DIVISION OF CLINICAL SCIENCES - NCI · 2024 · $1,247,492 — Our published studies pertaining to laboratory experiments and our related clinical protocols have clearly demonstrated that the DNA demethylating agent, Decitabine (DAC), the class I HDAC inhibitor, romidepsin, and the PRC2 inhibitor, DZNep alone or in combination can modulate gene expression in th…
Thomas Pohida · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2024 · $732,263 — The research and development activities of the Instrumentation Development and Engineering Application Solutions (IDEAS) resource are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodol…
David Margulies · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $370,759 — The focus of this work has been to understand the molecular details that control initial steps in the recognition of cells infected with pathogens such as viruses by cells of the innate and adaptive immune systems. Understanding the function, mechanism, structure, and evolution of the interaction of…
Thomas Nutman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $1,082,746 — Our research encompasses several key areas: evaluating tuberculosis (TB) treatment outcomes in pulmonary tuberculosis, investigating the impact of helminthic infections on type 2 diabetes mellitus, exploring how coinfections and comorbidities such as undernutrition modulate immune responses in tuber…
Christina Yek · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $1,364,178 — A DIVERSE PATHOGEN LANDSCAPE IS RESPONSIBLE FOR ACUTE FEBRILE ILLNESS IN CAMBODIA. In 2019, we implemented an in-country pathogen short-read sequencing pipeline for evaluation of clinical samples from febrile patients aged 6 months to 65 years of age in peri-urban Cambodia (NIH 19-I-N109). As of 20…
Andrea Lisco · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $71,700 — The extraordinarily wide spectrum of clinical manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, ranging from completely asymptomatic to fatal disease, represents an unexpected and yet unexplained clinical feature for an emerging highly contagious …
Michael Grigg · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $360,385 — Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the etiologic agent of COVID-19, emerged in 2019 as a public health emergency and global pandemic. SARS-CoV-2 is a linear, non-segmented, capped, polyadenylated positive-sense, single stranded RNA virus related to SARS-CoV and MERS-CoV, t…
Mark Connors · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $37,880 — Our laboratory is engaged in the study of the immune response to SARS-CoV-2 in two major areas. The first of these is the study of the immune response to natural infection. The second is the response to virus-like particles or replicating recombinant adenovirus type 4 (Ad4) vaccines. We are colla…