Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Emily Ricotta · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $294,282 — COVID-19 is caused by the novel SARS-CoV-2 and is associated with a hyper-inflammatory immune response which leads to severe and potentially life-threatening symptoms. Little is known about how and the extent to which COVID-19 presents in people with immunodeficiencies, but because of the known seve…
Emily Ricotta · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $194,408 — Work on this project began with the publication of an opinion piece in Nature Medicine on the need for improving nonrandomized clinical studies from an epidemiologic, ethical, and legal standpoint. Meta-research is currently underway to evaluate early data availability, data collection methodology,…
Dori R Germolec · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $144,446 — Our current work focuses on investigating specific cellular functions that have been demonstrated to be relevant to respiratory viral infection, including (influenza and SARS-CoV-2), susceptibility and pathogenesis by evaluating inflammatory and innate and adaptive immune responses. We are using an …
Christine P Grady · CLINICAL CENTER · 2024 — Nurses are vital members of our health care workforce. Faced with challenging ethical issues in practice, nurses routinely make difficult ethical decisions. This study is a survey of practicing nurses in 4 U.S. states (Massachusetts, Maryland, California, and Ohio) representing different regions o…
Sameer Kadri · CLINICAL CENTER · 2024 — Critical illness and sepsis (including critical disease from COVID-19) are associated with significant morbidity and mortality, especially in conditions where existing therapeutic strategies remain suboptimal. Our primary aim is to leverage large repositories of granular clinical data to better unde…
Michael B Fessler · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $3,014,749 — The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its 18th year at the NIEHS. Publications since the last annual report include: 1. A collaborative report…
Jacqueline Mays · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2024 · $1,939,380 — Our initial studies have focused on patients who have undergone allogeneic hematopoietic cell transplantation (HCT) as curative therapy primarily for hematological malignancies. Approximately 50% of allogeneic HCT recipients develop chronic Graft-Versus-Host-Disease (cGVHD), a multi-organ autoimmune…
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $1,590,720 — The Environmental Polymorphisms Registry (EPR), now called Personalized Environment and Genes Study (PEGS) of over 17,000 participants provides a unique resource for a variety of studies dedicated to clarifying the interaction of genetic and environmental determinants of human health. The PEGS's sub…
Vijay Arjun Ramchandani · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · 2024 · $1,904,646 — I. Intravenous Alcohol Self-Administration (IV-ASA) The IV-ASA paradigm models the trajectory of an individual’s preferred alcohol exposure in the lab, and is a unique approach to assess binge consumption, i.e., consuming alcohol to BrACs >0.08%, under highly controlled conditions. Binge drinking i…
Dima A Hammoud · CLINICAL CENTER · 2024 — Progress: • HIV project: We have optimized our model of Gp120 expression in a tumor model and succeeflly imaged the animals using 18F-lableed nanobodies. We also developed, in collaboration with NHLBI investigators, a method for site specific labeling of the nanobodies. We found that site-specifical…
Bradford Wood · CLINICAL CENTER · 2024 — A multidisciplinary multi-institute, public-private partnership tackled the goal of developing and validating AI tools and standardized methodologies for clinical dynamics and novel classification tools for medical imaging, voice analysis, data sharing, and detection and prevention of dynamic diseas…
Alison Motsinger-Reif · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $912,836 — MIBCOVIS Framework: Led by Dr. Benedict Anchang's group, we introduced MIBCOVIS, a framework that improves the visualization and interpretation of complex biological data without needing ground truth. MIBCOVIS combines various metrics within a Bayesian model to assess data reduction methods, applied…
Joan Packenham · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $914,695 — This research study seeks to understand the long-term impacts of COVID-19 on minority women and their families to assist in developing community-based interventions for recovery and resiliency. During the past year, our project has made substantial progress on additional selection of biomarkers, res…
Nicole Doria-Rose · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $1,368,169 — During the past years, the Virology Laboratory has collaborated with other intramural NIAID labs and other external collaborators to develop a pseudovirus neutralization assay and an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). For the neutralization assay, w…
Lauren Atlas · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · 2024 · $227,578 — Pain can be modulated by interpersonal processes that support the patient-provider relationship, and contextual factors related to the treatment environment. For example, placebo effects reflect the positive influence of social contexts on pain relief, whereas health disparities in pain are subject …
Clement McDonald · NATIONAL LIBRARY OF MEDICINE · 2024 · $1,454,664 — A. Possible Beneficial and Adverse Drug Effects on SARS-COV-2 Infections (COVID-19) We have identified one set of drugs used in ambulatory care that might reduce or increase incidence and/or severity of COVID-19. This combination is being tested in clinical trials, but the number of subjects has bee…
Sameer Antani · NATIONAL LIBRARY OF MEDICINE · 2024 · $1,370,493 — ML/AI driven automated computer-aided diagnostic (CADx) tools are designed to detect, localize, classify and grade disease in medical images to augment human-expert decision-making, add efficiencies, and improve overall performance. However, reliability of the predictions depends significantly on se…
Maryland Pao · NATIONAL INSTITUTE OF MENTAL HEALTH · 2024 · $1,130,023 — NIMH Clinical Research Support: The aim of the Research Volunteer (RV) protocol (NCT03304665) is to recruit and screen adult healthy volunteers for participation in NIMH IRP research studies. This study was transferred to a Carlos Zarate in 2024 (ZIA MH002927-15). The Ask Suicide Screening Question…
Tonya White · NATIONAL INSTITUTE OF MENTAL HEALTH · 2024 · $2,106,102 — We have focused on four primary projects in the past year comprised of i). evaluating the best practices for analyzing longitudinal data; ii). evaluating a large cohort of twins from Virginia Commonwealth University's Mid-Atlantic Twin Registry with the goal to assess genetic and environmental chara…
Avindra Nath · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2024 · $1,451,554 — Objective: The primary objective is to explore the clinical and biological phenotypes of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) and post-acute sequelae of COVID-19 (PASC). The secondary objective is to explore the pathophysiology of fatigue and post-exertiona…