Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
LYLE G BEST · MISSOURI BREAKS RESEARCH, INC. · 2024 · $525,404 — Title: FIPA2 M-PI: Best/Erdei/Torgerson Project Summary Pediatric asthma in American Indian (AI) communities of the Northern Plains Region presents a serious health disparity. While many previous works carried out in minority communities – but not in AI children- looked at individual level of influ…
Larry S. Schlesinger · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2024 · $7,483,557 — OVERALL ABSTRACT The Mission of the Southwest National Primate Research Center (SNPRC) is to improve the health of our global community through innovative biomedical research with nonhuman primates (NHPs). One way that it achieves this goal is by serving as a global resource to scientists that ca…
Sean T. Hanlon · RESEARCH TRIANGLE INSTITUTE · 2024 · $7,994,888 — 0BPROJECT SUMMARY/ABSTRACT The global pandemic caused by SARS-CoV-2 highlighted the continual threat of emerging and re-emerging pandemic-potential pathogens and the critical value of coordinated multidisciplinary basic and translational research for pandemic preparedness. There is an urgent need fo…
Anna Karolina Palucka · JACKSON LABORATORY · 2024 · $233,445 — PROJECT SUMMARY Although humanized mice have been successfully used for in vivo studies of HIV infection, cancer and immunotherapies, human naïve and adaptive immune responses remain suboptimal, with limited cross-reactivity between murine and human cytokines considered as a key contributing factor.…
STEVEN A BENNER · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · 2024 · $671,088 — Basic Research to Diagnostics and Surveillance in Lower Resource Environments Foundation for Applied Molecular Evolution Steven A. Benner ABSTRACT We will deliver to the NIAID and CDC communities, through basic research, a scientific understanding of pairing, mispairing, and enzymology of natural …
Karen Marie Dobos · COLORADO STATE UNIVERSITY · 2024 · $2,877,411 — Project Summary: The Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University (CSU) has been responsive to the national RBL mission to: 1) “Conduct research on biodefense and emerging infectious disease agents”; 2) “Be available and prepared to assist national, state, a…
Julianne Meisner · UNIVERSITY OF WASHINGTON · 2024 · $720,456 — ABSTRACT Endemic and emerging zoonoses both represent profound threats to public health. While these two disease systems diverge in many ways, fundamental to both is the importance contact networks in which humans and animals mix. In STI research and veterinary epidemiology, analysis of human-only a…
Charles Langelier · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $662,381 — SUMMARY Sepsis is a leading cause of death in hospitalized patients and involves a dysregulated host inflammatory response to infection. Despite decades of clinical trials, no new, effective treatments have been identified, and mortality rates remain unacceptably high. Several factors have contribut…
Michelle Weiss Katzow · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2024 · $193,928 — PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award (K23) proposal will address an urgent need to advance the science of child obesity prevention in low-income, minority communities, a priority of the National Heart, Lung, and Blood Institute. Simultaneously, it…
Diego G Diel · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $760,378 — The ongoing pandemic of COVID-19 is designated by World Health Organization (WHO) as a Public Health Emergency of International Concern. Similarities among ACE2 receptors predict that there are several animals could function as reservoirs for the virus. Recent studies by us and others identified fel…
SILVA A ARSLANIAN · WASHINGTON UNIVERSITY · 2024 · $607,058 — Type 2 diabetes mellitus (T2D) is a significant public health problem affecting ~30 million American. Obesity, insulin resistance, insulin deficiency (β cell dysfunction) and dysglycemia all precede the diagnosis of T2D and are known to promote inflammation and ultimately lead to microvascular compl…
Michael F. Berger · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $697,771 — PROJECT SUMMARY The development of novel therapies is at the core of improving cancer outcomes worldwide. However, currently used metrics to capture clinical benefit of these novel therapies may not always capture treatment success or failure. The overarching goal of the proposed research is to incr…
Soumen Paul · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $426,397 — Abstract Placental dysfunction leads to pregnancy-associated disorders, including intrauterine growth restriction (IUGR) and preeclampsia, and also serves as a developmental cause for postnatal and adult diseases. Often, the causal alterations in the placentation process, which lead to defective pre…
Jose Manuel Cerrato · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $1,774,184 — OVERALL Summary METALS The UNM Metal Exposure and Toxicity Assessment on tribal Lands of the Southwest SRP Center (METALS) focuses on >500 abandoned uranium mines (AUMs) on Navajo Nation, and the Jackpile Mine on Laguna Pueblo, a legacy of the Cold War now being assessed under CERCLA. They represent…
Benjamin L. Wright · MAYO CLINIC ARIZONA · 2024 · $189,864 — ABSTRACT This K23 award application requests support for the career development of Dr. Benjamin Wright, Assistant Professor in the Division of Allergy, Asthma and Clinical Immunology at Mayo Clinic Arizona. The candidate’s overall goal is to become an independent, clinician-investigator and improve …
Laurie E Cutting · VANDERBILT UNIVERSITY · 2024 · $667,838 — PROJECT SUMMARY About 60% of children can’t read proficiently, which is concerning as reading comprehension (RC) is linked to educational, vocational, and health outcomes. While a robust neurocognitive literature exists on word-level processes, a necessary but not sufficient skill for RC, similar st…
DANIEL R BROOKS · RESEARCH TRIANGLE INSTITUTE · 2024 · $1,143,873 — PROJECT SUMMARY/ABSTRACT A growing number of geographically diverse regions around the world report increasing rates of chronic kidney disease of uncertain or unknown etiology (CKDu), a life-threatening condition not attributable to traditional chronic kidney disease risk factors. Yet, the etiology …
Stuart Berger · LURIE CHILDREN'S HOSPITAL OF CHICAGO · 2024 · $408,351 — This application for the "Allogeneic Human Mesenchymal Stem Cell (MSC) Injection in Patients with Hypoplastic Left Heart Syndrome: A Phase IIb Clinical Trial (ELPIS)" Clinical Coordinating Center (CCC) is collaborative with the ELPIS Data Coordinating Center (DCC) application. The CCC will have ulti…
Wen Jiang · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $539,426 — PROJECT SUMMARY Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic cancers. However, for solid tumors, CAR T cells face challenges including intratumor heterogeneity, dynamic expression of target receptors, and often the inability for T cells to traffic t…
Won Hee Lee · UNIVERSITY OF ARIZONA · 2024 · $529,969 — PROJECT SUMMARY There has been a significant decline in cancer related mortality, partly due to the emergence of molecular targeted therapies. Unfortunately, the success of these drugs including tyrosine kinase inhibitors (TKIs) has been tempered by a concomitant rise in the prevalence of cancer the…