NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
David George Ashbrook · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $706,249 — As the average age of the population increases, understanding the biology of longevity and diseases of aging is increasingly important. The key role of mitochondria in Alzheimer’s disease (AD) and pathogenic aging has been established in studies across species and mechanistically validated using gen…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Andrew Sivaprakasam · PURDUE UNIVERSITY · 2024 · $53,974 — Abstract: Sensorineural hearing loss occurs in 15% of American adults and current treatment protocols are often guided by limited and archaic diagnostics. Not all types of sensorineural hearing loss are identical in physiology and a major priority of current auditory research is to innovate in the s…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
John H.R. Maunsell · UNIVERSITY OF CHICAGO · 2024 · $445,740 — Project Summary Optimal allocation of attention is key to achieving peak behavioral performance. A detailed understanding of the neuronal mechanisms that control attention will be essential for any comprehensive strategies to reduce attention lapses or treat attention disorders. Moreover, better un…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Camilla Ferreira Wenceslau · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $372,500 — PROJECT SUMMARY WENCESLAU, CAMILLA F. One of the major pathophysiological characteristics of hypertension is the presence of vascular remodeling. Accordingly, it has been shown that 100% hypertensive subjects present small artery remodeling. However, there is a gap in the literature in understandin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PHILLIP SCOTT · UNIVERSITY OF PENNSYLVANIA · 2024 · $557,812 — Project Summary Cutaneous leishmaniasis is a major neglected tropical disease that is associated with clinical manifestations ranging in severity from relatively benign lesions to chronic highly ulcerated lesions to metastatic disease. Optimally, drug treatment would eliminate the parasites, but dru…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Judit Villen · UNIVERSITY OF WASHINGTON · 2024 · $419,850 — PROJECT SUMMARY Protein phosphorylation is the most important and most extensively studied mechanism by which cells rapidly sense signals, transduce signals, and execute decisions. Protein phosphorylation provides a means to dynamically regulate protein function, is integral to all cellular processe…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JOHN M HAWDON · GEORGE WASHINGTON UNIVERSITY · 2024 · $201,875 — SUMMARY Hookworm infection remains one of the most important public health threats worldwide, with an estimated 450 million infected. Heavy hookworm infection is the leading cause of anemia in the tropics, resulting in debilitating and sometimes fatal iron-deficiency anemia. Children, pregnant women…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ulrike Dydak · PURDUE UNIVERSITY · 2024 · $561,236 — ABSTRACT Exposure to manganese (Mn) through inhalation of welding fumes continues to be a health risk factor, resulting in accumulation of brain Mn and neurochemical changes in welders, which further lead to changes in mood, cognitive and motor function. Yet, not much is known about the dose-respons…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Polyxeni Philippidou · CASE WESTERN RESERVE UNIVERSITY · 2024 · $333,915 — Breathing is the most fundamental motor behavior for terrestrial vertebrates. The frequency and amplitude of breathing movements are controlled by neural networks residing in the brainstem and spinal cord. In mammals, contraction of the diaphragm muscle is essential for driving airflow into the lung…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ERIN G REED · NORTHEAST OHIO MEDICAL UNIVERSITY · 2024 · $390,000 — PROJECT SUMMARY/ABSTRACT Although women are known to be disproportionally affected by Alzheimer’s disease (AD), the underlying biology for this difference is unresolved. Our long-term goal is to help develop therapies that can be used in the prevention and treatment of Alzheimer’s disease and other…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JEAN C. BECKHAM · DURHAM VA MEDICAL CENTER · 2024 — On average, 18 Veterans die by suicide each day. In fact, from 2009 to 2018, more than 64,000 Veterans died by suicide, which is roughly the same number of U.S. military fatalities that resulted from the wars in Vietnam, Iraq, and Afghanistan combined. While heritability estimates for suicidal thoug…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Matthew Shtrahman · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $416,198 — PROJECT SUMMARY Medicine is currently undergoing a revolution, where viable gene therapies are being developed for multiple disorders, including diseases of the central nervous system (CNS). One of the obstacles that limits the use of gene therapy is the availability of safe and effective vectors f…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Alon Goren · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $784,231 — PROJECT SUMMARY Autism spectrum disorder (ASD), which is usually accompanied of intellectual disability (ID), is part of a group of neurodevelopmental disorders that are usually diagnosed during the first two years of age. The social, emotional and communication skills of affected individuals are se…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mehdi Hedjazi Moghari · UNIVERSITY OF COLORADO DENVER · 2024 · $210,927 — Abstract Congenital heart disease (CHD) affects approximately 1.2% of children and is the leading cause of birth defect- related deaths. Single ventricle heart disease (SVHD) is a severe form of CHD, with high morbidity and mortality. These patients require multiple palliative surgeries, culminating…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Nam Y Lee · UNIVERSITY OF ARIZONA · 2024 · $367,649 — ABSTRACT TGF-β affects virtually all aspects of mammalian physiology starting from early embryonic development to adult tissue homeostasis through regulation of diverse cellular functions including proliferation, differentiation, and apoptosis. TGF-β signaling also plays an important role in cell me…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Marie Krousel-Wood · TULANE UNIVERSITY OF LOUISIANA · 2024 · $2,256,760 — Critical to the success of clinical care and translational science is an awareness by clinicians and researchers that diseases are characterized by sex and gender differences in epidemiology, pathophysiology, manifestations, progression, and response to treatment. Harnessing the biological forces th…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Caterina M Gallippi · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $656,400 — PROJECT SUMMARY For the 786,000 people in the United States living with end stage renal disease (ESRD), the treatment of choice is kidney transplantation. While transplant life has subtly increased over the last 15 years, ten-year graft survival rates are only 28% for deceased-donor and 46% for livi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rebecca Sandlin · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $567,229 — PROJECT SUMMARY Drosophila research labs routinely maintain hundreds to thousands of unique strains. Not only is this practice labor and resource intensive, but there is a risk that valuable strains will be lost, contaminated, or acquire additional mutations. This limitation would be overcome by the…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Taiping Chen · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $227,205 — PROJECT SUMMARY/ABSTRACT DNA cytosine methylation yielding 5-methylcytosine (5mC) is a major epigenetic modification involved in the regulation of chromatin structure and gene expression. Mammalian DNA methylation is catalyzed by three DNA methyltransferases (DNMTs), belonging to two structurally an…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Donghai Liang · EMORY UNIVERSITY · 2024 · $654,756 — PROJECT SUMMARY Exposures to prenatal traffic-related air pollution (TRAP), a primary contributor to urban air pollution, have been linked to adverse birth outcomes including preterm birth (PTB). Notably, communities of color, especially African American people, are disproportionately exposed to hig…