Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Robert W. Burgess · JACKSON LABORATORY · 2024 · $265,500 — PROJECT SUMMARY Charcot-Marie-Tooth disease (CMT) is a collection of inherited peripheral neuropathies with a cumulative incidence of ~1:2500 people. There is no approved treatment for any of the 100 genetic subtypes of CMT, presenting a large unmet clinical need. At least five forms of CMT are caus…
Roberta Marques Lassance-Soares · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $115,125 — Abstract Critical limb ischemia (CLI) is the end stage of peripheral artery disease (PAD) and can be an underlying cause of ischemic rest pain, gangrene, and amputation. Primary amputation is often required for the 30% of CLI patients who are not eligible for limb revascularization; thus, an effecti…
Ioannis Koutroulis · CHILDREN'S RESEARCH INSTITUTE · 2024 · $273,000 — Project Summary/Abstract: Septic encephalopathy (SE) constitutes a common form of encephalopathy with an associated 70% mortality rate, underscoring the need for a highly effective treatment. The pathophysiology of SE is linked to an energetic crisis in the brain combined with immune-mediated neuro-…
Michael William Donnino · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $365,165 — ABSTRACT There are currently limited medicinal interventions demonstrated to improve outcomes in patients with acute severe non-autoimmune pancreatitis, a highly morbid and potentially fatal condition which is estimated to afflict up to 275,000 patients annually in the US.[1] Early-stage mild pancre…
Jeffrey C Rathmell · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $511,194 — SUMMARY Exploiting immunity to eliminate cancer cells offers tremendous new therapeutic opportunities, including the widely employed immune checkpoint blockade (ICB) agents. These approaches are challenged, however, by the multitude of mechanisms through which tumors can suppress anti-tumor immunit…
Jarrod R. Fortwendel · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $656,395 — A critical barrier to overcoming triazole resistance in Aspergillus fumigatus is the significant lack of understanding of its genetic and molecular basis. We have shown that the known mechanisms of resistance do not fully explain resistance observed among most clinical isolates. Our long-term goal i…
Jesse Joshua Smith · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $580,684 — We propose to develop rectal cancer organoids (tumoroids) as individualized models and to build a large rectal cancer tumoroid repository. Research on rectal cancers is hampered by the paucity of models. Of the few existing in vivo models of rectal cancer, none place the tumors in the rectal lumen, …
Chao Lu · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $444,406 — PROJECT SUMMARY Head and Neck Squamous Cell Carcinomas (HNSCC) affect ~60,000 individuals in the US every year. Despite aggressive treatment, the 5-year survival rate for HNSCC remains ~50% and frequently patients suffer relapse and the development of metastatic lesions. Our previous work showed tha…
Katherine W Ferrara · STANFORD UNIVERSITY · 2024 · $604,889 — We seek to create a real-time ultrasound imaging tool for guiding interventions, with resolution that exceeds that obtained using CT but without the need for radiation or iodinated contrast agents. Advancements in medical imaging and device technology allow minimally-invasive procedures for the diag…
Alyssa Huff · SEATTLE CHILDREN'S HOSPITAL · 2024 · $78,892 — PROJECT SUMMARY Coordination of breathing with postinspiratory behaviors such as swallowing and laryngeal adduction is essential to health. Dysregulation of laryngeal activity during postinspiration and swallow occurs in many neurological and breathing-related disorders, such as obstructive sleep ap…
Collin Merrill · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $157,058 — Alcohol misuse affects millions of people, resulting in numerous deaths each year. People who are resistant alcohol intoxication and sedation are more likely to consume high levels of alcohol (binge drinking) and are at higher risk of developing alcohol use disorder. One mechanism underlying the dev…
Robert Wirka · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $122,700 — The purpose of this award is to provide Dr. Robert Wirka protected time, allowing him to obtain the training necessary to become an independent investigator using human genetic findings to define novel mechanisms driving coronary artery disease (CAD). Career development activities are designed to st…
Jared Schwartzer · MOUNT HOLYOKE COLLEGE · 2024 · $443,738 — PROJECT SUMMARY/ABSTRACT The state of the mother's immune system during pregnancy plays an important role in fetal development, and disruptions in this immune balance are associated with a range of neuropsychiatric and neurodevelopmental disorders. Epidemiological and clinical studies have revealed…
XUEMIN WANG · UNIVERSITY OF MISSOURI-ST. LOUIS · 2024 · $295,695 — PROJECT SUMMARY Misalignments and disruption of the circadian clock lead to metabolic and physiological dysfunctions. The clock regulates metabolism whereas metabolic activities feedback to influence circadian rhythms, and this interplay between the clock and metabolism coordinates physiology. Howev…
Caitlin Dugdale · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $172,748 — Project Summary HIV-exposed infants experience high rates of adverse birth outcomes, including stillbirth, preterm birth, small for gestational age, and neonatal death. These birth outcomes carry substantial morbidity and mortality in sub- Saharan Africa (SSA) where access to neonatal intensive care…
Annie Lu Nguyen · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $128,437 — PROJECT SUMMARY/ABSTRACT Advancements in therapy have drastically improved life expectancy for people living with HIV and many individuals are living well into older adulthood. Older adults living with HIV, defined as those who are 50 years and older, make up almost half of all individuals living w…
Neil Johnson · RESEARCH INST OF FOX CHASE CAN CTR · 2024 · $408,548 — PROJECT SUMMARY Genetic disruption of DNA polymerase theta (Polθ) activity has been shown to effectively target BRCA1 mutated cells, while leaving BRCA1 wild-type (WT) cells intact. Polθ facilitates theta-mediated DNA end joining (TMEJ) repair by promoting DNA synapsis and repair synthesis at break …
Sheng Cai · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $848,075 — PROJECT SUMMARY The proposed Leukemia Translational Science Center (LTSC), will generate, coordinate and lead translational studies in leukemia within ECOG-ACRIN and within the National Clinical Trials Network (NCTN). The LTSC will serve as the central hub for studies of the Leukemia Laboratory Comm…
BRADLEY D JONES · UNIVERSITY OF IOWA · 2024 · $77,750 — Project Abstract Salmonellosis continues to be one of the most important causes of food-borne illness in the U.S. Furthermore, multiple-antibiotic resistant Salmonella strains are becoming untreatable infectious diseases. Poultry meat and eggs are major sources of Salmonella food-borne illness, due …
Sharon Diskin · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $178,000 — PROJECT SUMMARY Brain tumors are the most common form of cancer in children between 0-19 years of age in the United States, and are the largest cause of cancer-related deaths. Our long term goal is to improve the outcomes of children diagnosed with brain tumors by characterizing the germline and som…