Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Kenneth S. Ramos · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · 2024 · $643,873 — Abstract Functional genomics studies have unraveled many of the instructions encoded in the human genome. Taking advantage of significant advances in parallel sequencing and a wide diversity of other protocols, studies are proposed in this application to resolve gene-environment interactions that de…
Mark O. Huising · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $462,960 — Half of US adults have diabetes or pre-diabetes, illustrating a critical need for novel treatments. There is a fundamental gap in the understanding of how paracrine feedback in the islet controls insulin and glucagon. The long-term goal is to elucidate the (patho)physiological crosstalk within pancr…
Susan L Calcaterra · UNIVERSITY OF COLORADO DENVER · 2024 · $189,043 — PROJECT ABSTRACT With the career goal of becoming an independent health services researcher, Dr. Susan Calcaterra describes a mentored research project and a rigorous career development plan which will prepare her to become a leader in the integration of opioid use disorder (OUD) treatment in the ho…
ELISABETH D MARTINEZ · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $82,000 — Close to 75% of all non-small cell lung cancer (NSCLC) patients receive radiation therapy at some point in their treatment regimen whether with curative or palliative intent. Radiation, which is currently given in a highly localized fashion, causes massive DNA damage leading to DSBs and cancer cell …
Hakho Lee · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $223,840 — Challenges. Tumor spheroids (and organoids) have become an instrumental tool in cancer research. These self-organized, three-dimensional (3D) systems can recapitulate phenotypic and functional traits of patient tumors in vivo, thereby serving as a powerful testing bed to study tumor heterogeneity, i…
Ernest W Wang · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $30,431 — PROJECT SUMMARY/ABSTRACT Manganese (Mn) is an essential cofactor for many cellular processes, but at elevated concentrations is known to exert neurotoxic effects on the brain. To date, population-based studies of Mn-exposed children and welders have consistently shown that chronic Mn exposure (X) i…
MICHELLE ALICE KELLIHER · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $502,500 — PROJECT SUMMARY/ABSTRACT The increased incidence of autoimmune and inflammatory disorders highlights the need for improved therapeutics to treat these diseases. Our work places RIPK1 kinase at the apex of inflammatory pathways where it regulates a form of inflammatory cell death called necroptosis m…
Paige C Arneson-Wissink · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $118,041 — PROJECT SUMMARY/ABSTRACT 80% of patients with Pancreatic Ductal Adenocarcinoma (PDAC) develop cachexia, which results in dispropor- tionate skeletal muscle mass loss, relative to caloric deficits. Cachexia causes functional impairment and ineli- gibility for anti-tumor therapeutic interventions, lea…
Zhenkun Lou · MAYO CLINIC ROCHESTER · 2024 · $345,528 — Triple negative breast cancer (TNBC) [estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) negative breast cancer is an aggressive subtype of breast cancer for which there are no approved targeted therapies. While standard chemotherapy reduces the r…
ROBERT P FISHER · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $507,000 — Project Summary RNA polymerase II (RNAPII), which catalyzes mRNA synthesis, is co-regulated by cyclin-dependent kinases (CDKs) and phosphatases to control transcription cycle progression and ensure coupling of elongation and processing. Derangements of the RNAPII cycle underlie cancer and other dise…
Eric J Bennett · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $590,920 — PROJECT SUMMARY Errors associated with DNA replication, transcription, mRNA processing, and protein biogenesis result in the continuous production of potentially toxic defective proteins. The error-prone nature of these essential processes requires robust quality control (QC) systems to effectively …
Sarwat I Chaudhry · YALE UNIVERSITY · 2024 · $530,760 — Acute myocardial infarction (AMI) is consistently ranked as one of the top five most expensive conditions billed to Medicare and has been the target of several cost containment measures, including Medicare’s Hospital Readmissions Reduction Program. To improve outcomes after AMI hospitalizations, pay…
Carmen Andreescu · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $2,938,462 — Mild Cognitive Impairment: A Prospective Community Study. Dementia is a leading cause of disability and death in older adults. Its incidence increases exponentially with age. Identifying independent risk factors and valid disease markers are critical steps towards prevention, improved diagnosis, and…
Mai ElMallah · DUKE UNIVERSITY · 2024 · $308,524 — ABSTRACT / PROJECT SUMMARY In response to a 30-year decline in the number of physician-scientists, attributed to prolonged clinical training, doubling or tripling of education debt, uncertain grant funding prospects, unclear career trajectories, and a lack of mentored research opportunities during e…
Krista F Huybrechts · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $526,905 — Mental health conditions are common among pregnant and postpartum women as well as non-pregnant women of reproductive age. While many patients require pharmacologic treatment, the safety of psychotropic medications in pregnancy is an area with large evidence gaps. Historically, spontaneous reports, …
Lynn Hua Lee · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $196,112 — Proposal Summary/Abstract: Though outcomes for pediatric acute leukemia have improved dramatically over the last few decades, infant leukemia is a particularly aggressive disease which remains difficult to cure even with chemotherapy intensification and bone marrow transplant. Most of these leukemia…
Domonique M Reed · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $22,331 — PROJECT SUMMARY/ABSTRACT Adolescent girls and young women (AGYW) in sub-Saharan Africa (SSA), the epicenter of the global HIV epidemic, have carried the primary burden of new HIV infections in this area for at least 30 years. Research has prioritized characterizing the individual predictors of HIV i…
WEIGUO CUI · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $400,000 — ABSTRACT T cell exhaustion is a differentiation state that is marked by the loss of effector function and increased expression of inhibitory receptors such as PD-1. Although virus-specific CD8 T cells are commonly considered as a homogeneous population that gradually become exhausted over time, rece…
BRIAN C LEWIS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $165,302 — Abstract The University of Massachusetts Chan Medical School seeks funding to continue its summer undergraduate research program for undergraduates from groups traditionally underrepresented – by race, ethnicity, economic and education disadvantage and disability status – in the biomedical sciences.…
Mary Elizabeth Ruth Hartnett · STANFORD UNIVERSITY · 2024 · $265,835 — PROJECT SUMMARY Age related macular degeneration (AMD) is a leading cause of vision loss in individuals over 55 years of age and is increasing as the world population becomes older. Treatment options for early AMD are limited and, therefore, vision will become increasingly threatened in the elderly …