Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MATTHEW AARON CIORBA · WASHINGTON UNIVERSITY · 2024 · $625,575 — Project Summary Although coronavirus disease 2019 (COVID-19) is primarily defined as a respiratory illness, up to 50% of patients experience clinical gastrointestinal symptoms, including nausea, abdominal pain, and diarrhea. We recently found that severe acute respiratory syndrome coronavirus 2 (SA…
Albert J. Auguste · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $206,342 — Abstract Orthobunyaviruses are an understudied genus in the order Bunyavirales that has no vaccines or therapies in clinical development. One of the prototype pathogens within this genus, as recently identified by NIAID, is Cache Valley virus (CVV). CVV is an emerging arthropod-borne virus that indu…
Paul Kievit · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $951,400 — The COVID-19 global pandemic caused by the novel SARS-CoV-2 coronavirus continues to result in significant morbidity and mortality worldwide. Although effective vaccines and therapeutics have been introduced, COVID-19 will continue to persist as a public health issue as a result of vaccine resistanc…
Archita P. Desai · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $129,301 — PROJECT SUMMARY Chronic liver disease (CLD) is a top-ten leading cause of death in Americans, aged 25-64, and ethnic minorities. Individuals with CLD suffer from lower health-related quality of life (HRQOL), disability and place a burden on their family caregivers. As individuals progress to end-sta…
Margaret Leighton McNairy · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $124,224 — ABSTRACT: The goals of this K24 proposal are to train clinical investigators in the conduct of patient-oriented cardiovascular disease (CVD) research primarily in Haiti, with a new project in Tanzania and to conduct a new study on environmental lead exposure and CVD risk factors in Haiti (Aim 1). Th…
Krishnan Padmanabhan · UNIVERSITY OF ROCHESTER · 2024 · $549,288 — Project Summary/Abstract The neural circuits associated with encoding odors in patterns of activity throughout the brain are critical not only for chemosensory perception, but are intimately linked to emotion, learning and memory in humans and mice, the major animal model for studying disorders that…
Ian Bass Seiple · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $84,553 — Project Summary/Abstract This proposal summarizes ongoing projects in our laboratory focused on natural product classes that have promising biological activity but are burdened with limitations that have prevented them from reaching their therapeutic potential. These classes are structurally comple…
Elizabeth Spencer Norton · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $1,882,579 — Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant…
Noe Cuauhtemoc Crespo · SAN DIEGO STATE UNIVERSITY · 2024 · $609,078 — Project Summary/Abstract The United States currently has the highest COVID-19 infection and related mortality rates in the world. In California, Latinos account for the highest percent of COVID-19 cases (58.9%) and deaths (47.3%) and are disproportionately represented in occupations deemed as ‘essen…
Eva-Maria Strauch · WASHINGTON UNIVERSITY · 2024 · $785,407 — Abstract With the advent of small, highly stable miniproteins and the ability to generate easily more, methods and prototypes for their applications both computationally as well as experimentally are needed. As part 1, we will investigate the potential of miniprotein-based fusion inhibitors. We will…
Alan D Castel · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $311,326 — ABSTRACT Changes in memory are one of the most common concerns of older adults. The proposed research examines how goals can motivate and improve memory in older adults through a strategic focus on selectively remembering important information. We first test how older adults can learn to focus on wh…
Katherine Camille Barnett · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $104,722 — Project Summary Acute respiratory distress syndrome (ARDS) causes COVID-19 fatalities and is linked to uncontrolled release of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF). Blockade of IL-1/IL-6 receptor signaling has shown success in treating seve…
Kathleen R Page · JOHNS HOPKINS UNIVERSITY · 2024 · $193,908 — Dr. Page is an Associate Professor of Medicine and infectious disease specialist engaged in clinical care, and public health research with a focus on expanding access to care for marginalized populations through community-engaged program building and evaluation. Over the last 15 years, her research …
Andrew Yates · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $487,050 — Project Summary Immunological memory is a defining characteristic of vertebrate immune systems, and is encoded in part by populations of T lymphocytes that respond rapidly and potently to repeat exposures to pathogens. These populations are remarkably diverse in their phenotypes and trafficking patt…
Matthew Frederick Campbell · UNIVERSITY OF PENNSYLVANIA · 2024 · $114,345 — Project Summary Objective: Respiratory viral infections affect millions of individuals each year. Conducting frequent widespread viral screening tests can curb outbreaks by quickly identifying infectious persons. Unfortunately, no screening diagnostic platform exists with the capacity to test hundre…
Nadia Natasha Abuelezam · BOSTON COLLEGE · 2024 · $389,962 — PROJECT ABSTRACT This research program aims to develop novel modeling methods, tools, and guidelines to incorporate racialized lived experiences into mathematical models of infectious disease transmission by explicitly modeling structural drivers of racial disparities in infectious disease exposure,…
Owen S Fenton · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $226,293 — ABSTRACT Melanoma is the deadliest form of skin cancer. The FDA-approved immune checkpoint inhibitors targeting PD1 and CTLA4 and the targeted therapies against BRAF and MEK have greatly improved overall survival in metastatic melanoma. Nevertheless, many patients die from metastatic melanoma inclu…
Nuala Jennings Meyer · UNIVERSITY OF PENNSYLVANIA · 2024 · $955,499 — This R35 proposal is to support a robust translational research program focused on sepsis-associated acute respiratory distress syndrome (ARDS), explaining individual risk and characterizing the ARDS host immune response in order to identify molecular traits that may respond differently to specific …
Rajender R Aparasu · UNIVERSITY OF HOUSTON · 2024 · $50,000 — ABSTRACT Medication-related morbidity and mortality are a significant health concern in older adults, who are highly susceptible to medication-related problems. Safe medication use practices require coordinated efforts by providers and patients in the medication use process. Medication-related probl…
Ronald G Collman · UNIVERSITY OF PENNSYLVANIA · 2024 · $2,940,869 — Overall Modified Project Summary/Abstract Section The Penn CFAR provides dynamic scientific leadership, organizational structure, resources, & infrastructure to advance AIDS research across the integrated campus of the University of Pennsylvania, Children’s Hospital of Philadelphia (CHOP) & the Wi…