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9873 documents

Common Post-Infectious Premature Epigenetic Aging

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Andrew R DiNardo · BAYLOR COLLEGE OF MEDICINE · 2024 · $614,367 — Project Summary: Last year in the United States, there were 1.3 million cases of pneumonia (excluding covid19). Worldwide, last year, there were 49 million cases respectively. Even after successful therapy, pneumonia and other severe infections are associated with >3-fold increased mortality risk d…

A Next Generation Data Infrastructure to Understand Disparities across the Life Course

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Arie Kapteyn · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $8,400,676 — Summary This infrastructure proposal aims to further advance capabilities in the social sciences (broadly defined) to collect data on the daily lives of U.S. families and individuals. These data will be more accurate, more granular, and more comprehensive than is currently possible in traditional s…

Cardiac Magnetic Resonance for Tissue Characterization Based Risk Stratification of Cardiopulmonary Symptoms, Effort Tolerance, and Prognosis Among COVID-19 Survivors

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jiwon Kim · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $625,046 — PROJECT SUMMARY / ABSTRACT Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic. Despite substantial short term mortality risk, the overwhelming majority of infected patients survive acute illness, resulting in a growing population at risk for long term events. Cardiopulmonary symptoms …

Center for Integrative Research on Childhood Adversity

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Julie May Croff · OSU CENTER FOR HEALTH SCIENCES · 2024 · $1,844,721 — ABSTRACT The goal of this Phase 2 CoBRE application is to expand on the accomplishments of Phase 1 in establishing an interdisciplinary and translational Center for Integrative Research on Childhood Adversity (CIRCA) at Oklahoma State University (OSU). Two decades of epidemiological data document th…

Project Nurture Expansion Study

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Deborah Jill Cohen · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $653,028 — PROJECT SUMMARY In the past 20 years, the United States (US) has seen a fourfold increase in the prevalence of maternal substance use disorders during pregnancy. Substance use during pregnancy is associated with adverse maternal and infant health outcomes. Numerous barriers impede the delivery of we…

Adapting COVID-19 Prenatal Care Innovations for Patients At Risk of Adverse Pregnancy Outcomes: a Mixed Methods Study of the Plan for Appropriate Tailored Healthcare in Pregnancy

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Alex Peahl · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $188,565 — PROJECT SUMMARY/ABSTRACT BACKGROUND: Prenatal care is a critical lever for improving maternity outcomes for the 4 million women who give birth annually. Yet, the traditional model of care—a uniform 14 in-person visits—overtreats and unduly burdens many patients. The COVID-19 pandemic rapidly transfo…

Genetic Investigation of Covid 19 in Lung Disease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MARK L KAHN · UNIVERSITY OF PENNSYLVANIA · 2024 · $869,001 — SUMMARY The COVID-19 pandemic due to the SARS-CoV-2 virus has resulted in millions of deaths worldwide. The majority of COVID-19 deaths are caused by lung disease characterized by alveolar filling and severe hypoxemia. Descriptive studies of human patients, animal models and cultured cells have supp…

Coordinated regeneration of lung epithelial and endothelial compartments

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Andrew Vaughan · UNIVERSITY OF PENNSYLVANIA · 2024 · $543,560 — Influenza alone kills as many as 500,000 people annually, and at least 4.5 million have died from SARS-CoV-2 during this ongoing pandemic, with mortality from both respiratory viruses largely due to viral pneumonia progressing to acute respiratory distress syndrome (ARDS). Significant focus has been…

Understand the molecular mechanism of age-associated decline in antiviral CD8 T cell immunity

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Tuoqi Wu · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $246,000 — Summary Immunosenescence increases morbidity and mortality after infection and reduces vaccine efficacy. Most deaths associated with infections by influenza virus, SARS-CoV, or SARS-CoV-2 occurred in people older than 65. Thus, understanding the mechanism of age-associated decline in antiviral immun…

Resources, Workforce Development, and Animal Models for the Rutgers RBL

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

David Alland · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $4,189,403 — Overall ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) therapeutic, pathogenesis, and diagnostic research on high threat biological agents with a focus on Mycobacterium tuberculosis and SARS-CoV-2, as wel…

Generating Research Opportunities Within Statistics at Fred Hutch (GROWS@FredHutch)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jeanne Ting Chowning · FRED HUTCHINSON CANCER CENTER · 2024 · $173,934 — Project Summary/Abstract In cancer research, the need for a diverse pool of researchers in statistics and data science has never been greater. Yet, the requisite academic pipeline for training such a workforce remains inadequate. Minority students admitted to statistics or biostatistics graduate pro…

Resources and Workforce Development for the Tulane Regional Biocontainment Laboratory

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JAY RAPPAPORT · TULANE UNIVERSITY OF LOUISIANA · 2024 · $2,842,544 — The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) dedicated to conducting nonhuman primate (NHP) research with the goal of improving human health. With a primary focus on infectious disease and biodefense research, the TNPRC is only NPRC wi…

Development of a screening diagnostic for the detection of viruses and bacteria from body fluids that utilizes the unparalleled structural characterization of mass spectrometry

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Aaron T Timperman · UNIVERSITY OF PENNSYLVANIA · 2024 · $202,368 — Project Summary/Abstract The long-term goal of this project is to develop of a rapid, inexpensive, and sensitive screening diagnostic based on an innovative broad proteomic approach to improve our ability to diagnose infectious disease, monitor changes in the microbiome, measure the state of the hos…

Enhancing SEBLAB Research Productivity, Operations and Core Laboratory Support

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Sixto Manuel Leal · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $2,683,615 — Project Summary The UAB Southeastern Biocontainment Laboratory (SEBLAB) is one of 12 Regional Biocontainment Laboratories (RBL) established by NIAID to advance BSL-3 research and pandemic preparedness. In continuous operation since 2009, NIAID award 1G20AI167409-01 enabled the repair of natural wear…

NARCH 12

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

SOHAIL Imran KHAN · CHEROKEE NATION · 2024 · $1,327,535 — Project Summary Major health inequities continue to impact tribal nations, yet a serious shortage of scientists who conduct tribally engaged research aimed at alleviating health disparities affecting American Indian (AI) people persists. For several years, Cherokee Nation, the University of Oklahoma…

An Efficacy Trial of Community Health Worker-Delivered Chronic Pain Self-Management Support for Vulnerable Older Adults

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Mary Rose Janevic · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $524,065 — Project Summary Chronic pain is an enormous public health problem, and African American older adults bear a disproportionate burden of disabling pain. Evidence-based chronic pain self-management support can improve pain-related functioning, yet standard models for providing this support are not well…

A Follow-up Study for Causes of Cancer in Black Women

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kimberly A. Bertrand · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $2,035,759 — High rates of chronic diseases, including many types of cancer, in U.S. Black women are widely recognized, but large gaps in knowledge remain. We began the Black Women’s Health Study (BWHS) in 1995 to identify reasons for this excess in chronic disease. At that time Black women represented a very sm…

RCMI Center for Health Disparities Research

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Cherise Baldwin Harrington · NORTH CAROLINA CENTRAL UNIVERSITY · 2024 · $3,580,236 — The North Carolina Central University (NCCU) seeks competitive renewal of its RCMI - Center for Health Disparities Research (RCHDR) to continue enhancing NCCU's research ecosystem to develop investigators who are conducting impactful and cutting-edge research to address health disparities (HD). The …

Improving the Immune Response to Nanoparticle-Based SARS-CoV-2 Vaccines

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Szu-Wen Wang · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $196,250 — PROJECT SUMMARY / ABSTRACT Vaccines have been very effective at protecting against infectious diseases that pose serious threats to human health. However, prophylactic vaccines can also be limited, particularly if antigenic drift occurs to create variants of the pathogen; this can result in vaccine…

Mechanisms underlying COVID-19 induced Neurocognitive Dysfunction

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

PAUL E SCHULZ · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $639,692 — PROJECT SUMMARY/ABSTRACT Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, which causes Coronavirus Disease 2019 (COVID-19), has become a global health crisis. To date, more than 6.5 million deaths from COVID-19 have been reported worldwide. Amongst survivors, neurocognitive dy…