Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Ayorkor Gaba · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $745,767 — PROJECT SUMMARY / ABSTRACT Addiction is a growing public health problem in the United States (U.S.), with nearly 21 million Americans meeting criteria for substance use disorder (SUD), 1.6 million meeting criteria for opioid use disorder (OUD), and opioid- related overdoses have increased by 50% ove…
JONATHAN M. FELDMAN · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $133,641 — Factors contributing to poor outcomes among minority patients with asthma include poverty and other social determinants of health (SDoH), poor medication adherence and self-management skills, and environmental exposures. There are challenges in providing asthma education in the outpatient setting, s…
Greg J Welk · IOWA STATE UNIVERSITY · 2024 · $349,352 — Summary The proposed project will evaluate the effectiveness of incorporating physical therapy exercises (primary prevention strategy) within an established physical activity intervention called Walk with Ease (WWE) to reduce incidence and risk of falls in community-dwelling older adults. The propo…
Michael A Hogarth · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $982,727 — PROJECT SUMMARY OVERALL The overall objective of the proposed UCSD Learning Health Systems (LHS) Center is to provide didactic and experiential training in learning health systems science to clinicians and other scientists from diverse backgrounds. The three cores of the Center – Administrative Core…
Jaideep Kapur · UNIVERSITY OF VIRGINIA · 2024 · $496,351 — Project summary Grand mal (great malady) seizures, now called generalized tonic clonic seizures (GTCS), are the most feared seizures because they can cause death and injury. Repeated GTCSs are the leading risk factor for sudden unexpected death in epilepsy (SUDEP), which is a leading cause of death …
Roberta Faccio · WASHINGTON UNIVERSITY · 2024 · $393,846 — ABSTRACT In order to survive, grow and metastasize, tumors need the support of a favorable host environment. Local changes in normal cells in close proximity to a developing tumor can create a favorable tumor micro-environment (TME) that is necessary for tumor growth. Mesenchymal populations, includ…
Partha Chandra · TULANE UNIVERSITY OF LOUISIANA · 2024 · $498,444 — Combined antiretroviral therapy (cART) suppresses HIV replication, but 30-60% of infected patients suffer from severe HIV-1 associated neurocognitive disorders (HAND). However, the mechanisms underlying HAND are unclear and this lack of information has prevented the development of effective science-…
Douglas B White · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $125,819 — The goal of this renewal K24 proposal is to enhance the ability of Dr. Douglas White to mentor clinician- scientists focused on developing and testing interventions to mitigate health disparities and promote goal-concordant care for incapacitated patients with acute respiratory failure (ARF). Patien…
Rebecca L Scalzo · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2024 — Type 2 Diabetes (T2D) is a major health priority within the VA. More than 24% of Veterans have T2D, twice the national average. There is an increasing population of female veterans in the VA in the premenopausal age range. Premenopausal women with T2D have poorer health-related outcomes compared wit…
Matthew A. Spinelli · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $781,821 — PROJECT SUMMARY/ ABSTRACT Rates of bacterial sexually transmitted infections (STIs) are rising globally, demanding innovative interventions beyond the scope of current efforts to prevent STIs. While HIV pre-exposure prophylaxis (PrEP) effectively reduces HIV acquisition risk, it does not address th…
Sheng Li · REHABTEK, LLC · 2024 · $1,000,000 — Stroke is a leading cause of adult disability, with more than 795,000 people having a stroke in the United States each year. Stroke survivors often experience loss of motor control and impaired function. Immediately after stroke, there is a time-limited window of heightened plasticity during which t…
MOHAMMED AKAABOUNE · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $426,301 — Stable and efficient synaptic transmission depends largely on the maintenance of a high number/density of postsynaptic receptors at synaptic sites. At the neuromuscular junction (NMJ), the synapse between spinal motor neurons and skeletal muscle cells, the mechanisms that regulate the stability of p…
Dorian K Rose · VETERANS HEALTH ADMINISTRATION · 2024 — Background/Purpose: Physical rehabilitation of walking post-stroke is designed to improve individuals' mobility in the presence of motor, sensory and balance impairments. Effective strategies to improve balance and decrease fall risk continue to be a need in stroke rehabilitation. To address this, o…
Jeffrey Michael Donlea · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $378,300 — Project Summary Sleep has been identified as a state of heightened neural plasticity, but the rules that govern reorganization during sleep remain unknown. To better identify the conditions under which synapses are pruned during sleep, we have begun to examine responses to neural injury in the fruit…
James Peter Basilion · CASE WESTERN RESERVE UNIVERSITY · 2024 · $409,926 — Project Summary/Abstract: Breast cancer is the most common cancer in women, with an estimated 246,660 cases (and 40,450 deaths) in the US during 2015. Due to better screening techniques cancers are caught earlier and 75% of patients are candidates for breast conserving surgery (BCS) to remove the ca…
Yi Fan · UNIVERSITY OF PENNSYLVANIA · 2024 · $386,788 — Project Summary Glioblastoma (GBM), the grade IV glioma, is among the most lethal of human malignancies, distinguished by prominent vascularity. GBM is the most aggressive primary brain tumor with a current median survival of about 14-16 months, largely due to its high resistance to conventional cyt…
Rafael Antonio Fissore · UNIVERSITY OF MASSACHUSETTS AMHERST · 2024 · $194,801 — There is a persistent gap in our knowledge of the sperm molecules and mechanisms that induce Ca2+ oscillations in mammalian eggs. Ca2+ release triggers egg activation and initiation of embryo development in all mammals, including human beings. A sperm molecule, the sperm factor, SF, later identified…
Jason G Kay · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $381,667 — Project Summary/Abstract Oral commensal microbes, including oral streptococci, are increasingly recognized as an essential component in the development of periodontal disease. Commensals contribute to the recruitment and growth of keystone disease-initiating microbes and are part of the dysbiotic d…
Sukyung Woo · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $410,155 — Project Abstract High-grade serous ovarian cancer (HGSOC) is the most common and lethal histology, accounting for 80% of ovarian cancer death. During peritoneal spread, tumor cells detached form multicellular spheroids (MTS), which survive better unattached and are more resistant to chemotherapy and…
Yun Sok Lee · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $379,200 — PROJECT SUMMARY/ABSTRACT The prevalence of Type 2 diabetes mellitus (T2DM) is rising dramatically on a global basis and has now reached epidemic proportions. Current anti-diabetic therapeutics are available, but are inadequate to fully control T2DM in most patients, resulting in a great deal of morb…