Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MOHSEN BAZARGAN · CHARLES R. DREW UNIVERSITY OF MED & SCI · 2024 · $400,115 — PROJECT SUMMARY/ABSTRACT The Charles R. Drew University of Medicine and Science (CDU) and the University of California, Los Angeles (UCLA) in partnership with the Los Angeles Community College District propose the Engaging Students in Aging Research (ESAR) Program. Racial/ethnic minorities are sever…
Georg Oeltzschner · JOHNS HOPKINS UNIVERSITY · 2024 · $245,254 — Project Summary Advanced multi-spectrum magnetic resonance spectroscopy (MRS) methods allow the non-invasive measurement of the concentration of neurochemicals, but also of other biophysical properties. The currently available one-dimensional modeling tools cannot adequately model such data because …
KAPIL BHALLA · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $452,068 — Myeloproliferative neoplasms with myelofibrosis (MPN-MF) exhibit constitutive activity of JAK-STAT signaling due to mutations in JAK2, c-MPL or calreticulin genes. Additional mutations in chromatin/transcriptional modifiers (epimutations) induce transformation to AML (sAML) in up to 20% of patients …
Robert Thomas Knight · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $525,493 — Abstract Prefrontal cortex (PFC) plays a pivotal role in distributed neural networks orchestrating human behavior. Notably, PFC dysfunction is observed in numerous debilitating developmental, neurological and psychiatric disorders. This emphasizes the need for improved knowledge of the physiology im…
Uma Reddy · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $359,801 — Abstract/Project Summary The Columbia Center has a 20-year track record of excellence within the Maternal Fetal Medicine Units (MFMU) Network and collaborating in large multi-site clinical trials and longitudinal studies in pregnant and lactating people. During the last current cycle of the MFMU, th…
Shefin Sam George · STANFORD UNIVERSITY · 2024 · $194,552 — Project Summary/Abstract The mechano-electrical transduction (MET) process allows the transduction of mechanical information from sound into electrical signals, and it is a fundamental step in cochlear system function. Failures in this process lead to hearing loss and deafness. Understanding the ba…
Paige Elizabeth Burrell · DUKE UNIVERSITY · 2024 · $41,391 — PROJECT SUMMARY. Ataxia-telangiectasia (A-T) is a pleiotropic genetic disorder caused by bi-allelic mutations in the Ataxia- telangiectasia, mutated (ATM) gene. A-T leads to numerous clinical symptoms, including radiosensitivity, sterility, immunodeficiency, insulin resistance, neurodegeneration, an…
Li Zhang · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $342,414 — PROJECT SUMMARY The adaptive immune system is responsible for the specific recognition and elimination of antigens originating from infection and disease. It recognizes antigens via an immense array of antigen-binding antibodies (B-cell receptors, BCRs) and T-cell receptors (TCRs), the immune repert…
Matthew Charles Keller · UNIVERSITY OF COLORADO · 2024 · $172,802 — PROJECT SUMMARY This proposal requests a further five years of funding to support the organization and delivery of in-person and virtual intensive training workshops focused on the development of skills in statistical, behavioral, and quantitative genetics that will advance the mission of NIMH. Four…
Matthew L Warman · BOSTON CHILDREN'S HOSPITAL · 2024 · $377,718 — Osteocalcin is among the most highly expressed proteins in bone. Based on studies performed using the Ocnm1 strain of osteocalcin knockout (KO) mice, osteocalcin was suggested to be a bone-derived hormone that regulates glucose metabolism, fat storage, male fertility, muscle mass, brain development,…
Chongyuan Luo · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $739,969 — PROJECT SUMMARY Large-scale genome-wide association studies (GWAS) have identified between a handful to hundreds of risk loci for each major type of neuropsychiatric disorders. One of the main challenges for the post-GWAS era is to determine the causal variants and dissect the regulatory mechanism i…
Michelle M Martinez · UNIVERSIDAD CENTRAL DEL CARIBE · 2024 · $117,029 — PROJECT SUMMARY Triple Negative Breast Cancer (TNBC) is an aggressive and lethal breast cancer subtype more commonly diagnosed on younger (<40y) women of color (Hispanics and African American), who are more likely to have disease recurrence and who have an overall shorter survival. Furthermore, addi…
JOSHUA Craig BRUMBERG · QUEENS COLLEGE · 2024 · $115,500 — Abstract Sensory Deprivation profoundly impacts cortical circuits which in turn impact organismal functioning from mouse to man. Traditionally research has focused on how neurons respond to changes in sensory experience during development. Recently attention has been drawn to non- neuronal elements …
Eric J. Vilain · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $2,096,755 — ABSTRACT Mendelian conditions, particularly those presenting during childhood, are a major disease burden causing suffering and taxing the healthcare system. Clinical approaches including exome sequencing have led to a rapid increase in the number of conditions with known genetic causes and new trea…
BENEDETTA J LEUNER · OHIO STATE UNIVERSITY · 2024 · $192,059 — PROJECT SUMMARY Hormonal contraceptives (HC) are used by 10 million people in the United States alone. While HC have played an important role in revolutionizing women’s health, the impact of HC on the brain have not been well studied, especially during adolescence when HC use often begins. There is …
Serena Sweet · VANDERBILT UNIVERSITY · 2024 · $31,694 — PROJECT SUMMARY Developmental programming of neural circuits modulating metabolic state is critical to maintain homeostasis. Despite an increasing prevalence of metabolic disorders, our understanding of the developmental integration of neural circuitry linking homeostatic drinking and feeding states…
KIMARA L TARGOFF · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $546,099 — PROJECT SUMMARY Due to the limited ability to mount a regenerative response in injured myocardium, cardiac dysfunction remains a key cause of morbidity and mortality. Coronary artery disease leads to myocardial infarction which results in fibrotic scarring, adverse remodeling, and heart failure. In …
Carlos Alberto Villalba-Galea · UNIVERSITY OF THE PACIFIC-STOCKTON · 2024 · $168,750 — Project Summary (Abstract): The proposed work seeks to identify the molecular basis for a novel interaction between two proteins that are typically found in electrically active cells such as neurons and cardiac muscles cells. One of the proteins is known as a voltage-dependent, potassium-selective K…
Takato Hiranita · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $396,736 — ABSTRACT/SUMMARY This application from a “New Investigator” is in response to Parent Announcement PA-20-185 “NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)” and requests 5 years of support to study the contribution of gabapentinoids to the opioid crisis. The number of opioid over…
Tobias Gerhard · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $518,903 — Despite almost complete absence of adequate data from head-to-head randomized controlled trials, treatment guidelines and prescription drug insurance formularies typically consider individual drugs within medication classes as equally effective and equally safe. Yet, incorrect assumptions regarding …