NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kayla Retallick-Townsley · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $30,103 — There is an urgent need to decipher the complex polygenic risk architecture of neuropsychiatric and neurodevelopmental disorders. Most disease-associated common variants are non-coding. Candidate risk loci in noncoding regions are often regulatory elements, such as enhancers and promoters, that may …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Philipp Oberdoerffer · JOHNS HOPKINS UNIVERSITY · 2024 · $229,659 — Project Summary Chromatin context defines all DNA transactions, from gene regulation to genome maintenance. Changes in chromatin composition are hallmarks of cancer cells that contribute to malignant transformation and have been studied extensively using a wide range of Next Generation Sequencing (N…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
EVGENY I ROGAEV · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $828,534 — Summary Molecular-genetic studies have illuminated the primary pathway of Alzheimer’s disease (AD). However, a relatively long chronic prodromal period of the disease, and the cascade of molecular events underlying the AD-associated synaptic and neuronal loss and neurodegeneration in the aging brain…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Michael John Skrajner · HOPEFUL AGING LLC · 2024 · $878,369 — PROJECT SUMMARY / ABSTRACT There are currently 6.7 million Americans living with dementia and, without significant breakthroughs, this figure will double to 12.7 million by 2050 (Rajan et al., 2021). There are about 46,000 long-term care (LTC) facilities in the U.S. (Harris-Kojetin et al, 2016). Mo…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Anand Kumar Rohatgi · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $122,720 — Project Summary Dr. Anand Rohatgi is a Professor in the Department of Internal Medicine/Division of Cardiology at UT Southwestern Medical Center. He has established a successful and independent research program focused on elucidating the role of HDL metabolism in cardiovascular disease. His experien…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Clinton D Allred · NATIONAL UNIVERSITY OF NATURAL MEDICINE · 2024 · $103,124 — R25 ENER-G Summary/Abstract There is a pressing need for nutrition-focused, methodologically sound, Evidence-Based Health Care (EBHC) skills training across the field of nutrition including the clinical interface. Emerging evidence points to largely low-quality systematic reviews informing clinical …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CHARLES A O'BRIEN · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $2,295,000 — PROJECT SUMMARY/ABSTRACT - OVERALL Conditions such as osteoporosis and osteoarthritis, and malignancies such as breast cancer, negatively affect the musculoskeletal system, leading to substantial disability and health care costs. Thus, there is an ongoing need to better understand the causes of the…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Nicole L Spartano · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $424,130 — Project Abstract Almost half of adults have either diabetes mellitus (DM) or prediabetes (preDM), but many of those have undiagnosed conditions. Current DM diagnosis and risk prediction are based on single “snapshot” measurements, including fasting blood glucose, postprandial glucose, and hemoglobin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sivaraj Sivaramakrishnan · UNIVERSITY OF MINNESOTA · 2024 · $477,751 — Project Summary Cell signaling and membrane traffic emerge from an ensemble of dynamic, transient protein-protein interactions (PPIs) in a crowded milieu. Traditional structural and biochemical approaches are mostly limited to dissecting the function of stable, structured PPIs. To address emergent f…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SAMIA MORA · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $126,184 — Project Summary/Abstract Dr, Mora is a cardiologist cross-trained in epidemiology who has devoted her career to patient-oriented research (POR) in cardiovascular prevention, focusing on the discovery and translational applications of lipid biomarkers of cardiometabolic disease risk, and developing i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ayyalusamy Ramamoorthy · FLORIDA STATE UNIVERSITY · 2024 · $354,275 — The accumulation of particular proteins into long fibrillar aggregates known as amyloids is a common feature of many devastating aging-related pathologies. In type II diabetes mellitus, the main constituent of these aggregates is Islet Amyloid Polypeptide (IAPP, also known as amylin). Like many othe…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Benjamin Brewster Risk · EMORY UNIVERSITY · 2024 · $709,145 — ABSTRACT Functional magnetic resonance imaging (fMRI) is used to estimate the correlations between brain regions. De- spite the many insights into brain function provided by fMRI, the field is currently experiencing a reproducibility crisis. For instance, autism spectrum disorder (ASD) is thought to …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SAMUEL MATEJ · UNIVERSITY OF PENNSYLVANIA · 2024 · $586,495 — Project Summary Clinical and research applications of the PET imaging are rapidly expanding from ever improving diagnostic and treatment assessment applications to guidance of personalized treatments, ultra-low dose imaging, and even interventional imaging procedures. Supporting these developments,…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Tessa Leigh Concepcion · UNIVERSITY OF WASHINGTON · 2024 · $43,050 — ABSTRACT This F31 proposal aims to evaluate pregnant and postpartum women’s preferences for different pre-exposure prophylaxis (PrEP) methods and identify early process indicators for implementing these options in maternal and child health (MCH) systems. HIV incidence remains unacceptability high am…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SUSAN S GOLDEN · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $677,095 — This project leverages a cyanobacterial model system to answer the following questions: what are the molecular interactions that mark the passage of time in a cell, where do they occur in the cell, how do they mediate temporal regulation of events, and why does biological timing matter for fitness? …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Samir Parekh · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $520,055 — PROJECT SUMMARY The era of “big data” has opened the door for genomic and systems biology approaches to be applied to current challenges in life sciences and precision medicine. One critical challenge in these areas is how to prioritize research findings to validate and identify actionable insights …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Thomas James Santangelo · COLORADO STATE UNIVERSITY · 2024 · $244,659 — Project Summary/Abstract The essential multi-subunit RNA polymerases are regulated at each stage of the transcription cycle to control gene expression in each Domain. In many cases the rate limiting step of gene expression is during transcription elongation, but major knowledge gaps remain in our un…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mary Linton B Peters · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $252,164 — Project Summary Recent evidence suggests that up to 10% of patients with Pancreatic Ductal AdenoCarcinoma (PDAC) harbor a germline genetic mutation in a cancer risk gene. For this reason, the National Comprehensive Cancer Network (NCCN) and American Society of Clinical Oncology (ASCO) recommend germ…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Julie Christina Markant · TULANE UNIVERSITY OF LOUISIANA · 2024 · $383,567 — SUMMARY/ABSTRACT Caregivers are both socially rewarding and a crucial source of learning input, and infants’ ability to prioritize attention to their caregiver over other competing stimuli is critical for effective early learning. Altered processing of social reward is common across several atypical…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Michael L. LeBlanc · FRED HUTCHINSON CANCER CENTER · 2024 · $8,319,732 — Project Summary/Abstract Overall Component The SWOG Statistics and Data Management Center (SDMC) provides leadership in the statistical design, data management, analysis, and reporting of NCTN clinical trials. It contributes to SWOG's overall mission to significantly improve lives through cancer cli…