Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
ANDERS M DALE · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $1,808,989 — PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is costly and burdensome. As the US population ages, AD’s public health impact continues to grow. NIH and Alzheimer’s Association consensus statements indicate that understanding early phases of disease progression—such as mild cognitive impairment (…
BRIAN C LEWIS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $556,470 — Abstract Pancreatic cancer is a leading cause of cancer-related deaths in the United States with an estimated 48,000 deaths in 2021. Prior work has identified several commonly occurring genetic alterations, including activating KRAS mutations in approximately 95% of pancreatic ductal adenocarcinoma …
MENG-FU BRYAN TSOU · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $390,410 — Project Summary Reproducible assembly of protein molecules from free amino acids requires external information stored in DNA/RNA (genome). In contrast, assembly of higher-order structures from individual protein molecules is thought to occur de novo, relying on information intrinsic to each protein …
Brian K Kobilka · STANFORD UNIVERSITY · 2024 · $549,378 — Project Summary/Abstract The structural basis for pathway-selective signaling by the µ-opioid receptor. For many patients experiencing acute and chronic pain, opioids like codeine, morphine, and fentanyl have improved their quality of life. Unfortunately, these benefits can be offset by dose-limitin…
Ravi Bharat Patel · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $671,254 — PROJECT SUMMARY Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are prevalent cardiovascular syndromes of aging that frequently co-exist. Unfortunately, clinical outcomes are worse among individuals with comorbid HFpEF and AF compared with either syndrome in isola…
Michael A Erb · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $570,856 — PROJECT SUMMARY/ABSTRACT Histone deacetylases (HAT) are zinc-dependent enzymes that catalyze the removal of acetyl groups from the epsilon amine of lysine side chains. These proteins have been widely pursued as anti-cancer drug targets, but therapeutic development has been largely unsuccessful given…
SCOTT D. RAMSEY · FRED HUTCHINSON CANCER CENTER · 2024 · $402,600 — Project Summary/Abstract Demographic changes in the commercially insured population following implementation of the Affordable Care Act (ACA)—specifically improved enrollment of the near-poor and those with chronic comorbidities--may have paradoxically magnified the problem of “underinsurance;” that…
Edward Chang · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $655,924 — PROJECT SUMMARY Multiple neurological diseases [e.g. spinal cord injury (SCI), amyotrophic lateral sclerosis (ALS), brain stem stroke] can all result in severe and devastating limb paralysis. A recent comprehensive assessment found that >200,000 patients suffer from tetraplegia or severe tetraparesi…
KRZYSZTOF KUCZERA · UNIVERSITY OF KANSAS LAWRENCE · 2024 · $487,741 — PROJECT SUMMARY Delivering molecules across the blood-brain barrier (BBB) represents a major challenge in treating mental disorders and central nervous system (CNS) disorders. Many therapeutic agents that have the potential to treat these disorders have difficulty entering the brain due to the prese…
Pankaj Kapahi · BUCK INSTITUTE FOR RESEARCH ON AGING · 2024 · $745,418 — PROJECT SUMMARY/ABSTRACT More than half of the elderly population suffer from age-related eye disorders that compromise their ability to perform daily activities. Aging is a significant risk factor for such disorders, and dietary restriction (DR) is a robust intervention that can slow aging and exte…
LAUREN M ABBATE · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2024 — Background: Exercise is an evidence-based intervention for the management of chronic conditions, yet the majority of Veterans are inactive. Group telehealth (GT) delivered exercise can potentially improve access to and participation in exercise. GT exercise sessions may increase exercise participati…
Kristy Brock · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $627,302 — As biomechanical modeling of the breast is integral to predicting tumor location across multimodal diagnostic imaging and during surgery, surgical planning, generating simulations for physician and patient education, and brassiere and clothing design for optimal breast support, advances in model acc…
Ivan H Wu · UNIVERSITY OF MINNESOTA · 2024 · $232,026 — PROJECT SUMMARY/ABSTRACT The proposed research aims to reduce obesity-related health disparities by promoting healthy lifestyle behav- iors among African Americans (AAs), given the high disease burdens associated with low physical activity, in- sufficient sleep, and obesity. To this end, the candida…
E Premkumar Reddy · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $187,642 — Abstract Approximately one third of patients suffering from acute myeloid leukemia (AML) harbor an internal tandem duplication in the FLT3 gene (FLT3-ITD), which is clinically associated with an increased rate of relapse in response to standard therapies. As a result, targeted small molecules such a…
MANAMI HARA · UNIVERSITY OF CHICAGO · 2024 · $764,894 — Project Summary/Abstract Increasing evidence has demonstrated that disease states of either endocrine or exocrine pancreas aggravate one another, which implies bi-directional blood flow between islets and exocrine cells. However, this is inconsistent with the current model of uni-directional blood f…
Helen M Bramlett · MIAMI VA HEALTH CARE SYSTEM · 2024 — Traumatic brain injury (TBI) is a leading cause of death and cognitive disability and is a known risk of military service. Women constitute a large share of servicemembers seeking care from the Veterans Health Administration. Women servicemembers, especially those …
Kin-Hing William Lau · VA LOMA LINDA HEALTHCARE SYSTEM · 2024 — The healing of ~10% of several million traumatic or nontraumatic fractures occurring annually in the US is delayed or impaired resulting in nonunion or delayed union. The annual cost for their treatment and management exceeds $20 billion, leading to considerable healthcare costs and human suffering.…
Christina Kim Holub · CALIFORNIA STATE UNIVERSITY SAN MARCOS · 2024 · $149,000 — Project Summary Life, as we know it, has changed due to COVID-19. Existing health disparities among underserved communities were exacerbated. Latinos and Native Hawaiians and Pacific Islanders (NHPI) disproportionately experience disparities in health, even when compared to other minority population…
Noah Stephen Philip · OCEAN STATE RESEARCH INSTITUTE, INC. · 2024 · $585,279 — PROJECT SUMMARY/ABSTRACT Current treatments for depression and anxiety are often limited by partial efficacy and significant side effects. These disorders constitute serious public health challenges due to significant burden of illness, and the lack of more effective treatments contributes to substa…
Tomasz Nowakowski · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $764,437 — Project Summary Microglial inflammation has been implicated the pathology of a host of neurological conditions, including neurodevelopmental disorders such as autism and Down Syndrome; neurogenerative disorders such as Alzheimer's disease (AD), Parkinson’s disease, amyotrophic lateral sclerosis (AL…