Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Laura D Straus · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — Posttraumatic Stress Disorder (PTSD) is common in Veterans and associated with a number of negative physical and mental health consequences. While evidence-based pharmacological and psychosocial interventions for PTSD have been developed, not all patients respond fully to treatment. Investigating th…
SUBHRA MOHAPATRA · JAMES A. HALEY VA MEDICAL CENTER · 2024 — This proposal seeks to renew Research Career Scientist Award held by Dr. Subhra Mohapatra, at the James A. Haley VA Hospital in Tampa, Florida since 2018. She is also a tenured- full professor (part-time) at the VA-affiliated academic center- the University of South Florida. She is the recipient of …
TAMARA J. PHILLIPS · PORTLAND VA MEDICAL CENTER · 2024 — Project Summary/Abstract Dr. Richards (Phillips) directs a research group within her laboratory, comprising a Senior Research Associate, full-time laboratory technicians, a graduate student, and several summer interns. She also directs the NIH/NIAAA-funded Portland Alcohol Research Center (PARC), wh…
Jie Fan · VETERANS HEALTH ADMINISTRATION · 2024 — PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003 and is a VA Research Career Scientist, a Director of the Surgical Research Program, a Vice- Chair of the Institutional Animal Care and Use Committee, a Mentor of VA Career Development Awa…
Nils Gehlenborg · HARVARD MEDICAL SCHOOL · 2024 · $567,343 — Project Summary Our rapidly evolving understanding of how genomes function and how genomic variation influences the development and progression of diseases drive our ability to develop novel diagnostics and therapeutics. Genomic data science plays a critical role in this process, relying on the avail…
COREY C HARWELL · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $376,474 — Project Summary Neuronal-glial relationships play a critical role in the regulation of synapse formation and neuronal specification. The cellular and molecular mechanisms by which neurons and astrocytes communicate and coordinate are not well understood. The experiments in this proposal will uncover…
Ge Tao · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $373,750 — Project Summary This proposal describes a five-year program to investigate the roles of paired-like homeodomain 2 (Pitx2) signaling during cellular injury response and fibrotic scar formation after myocardial infarction (MI). MI accounts for millions of deaths worldwide annually. Therefore, developi…
Alan Dardik · YALE UNIVERSITY · 2024 · $742,551 — The preferred vascular access for hemodialysis uses an arteriovenous fistula (AVF) to increase blood flow through a vein. Successful adaptation of the venous conduit to the arterial-like fistula environment requires remodeling of the vein wall without excessive wall thickening, enabling mechanical s…
Michael Jonathan Harms · UNIVERSITY OF OREGON · 2024 · $364,885 — SUMMARY Understanding the evolution of protein function is a central goal in evolutionary biochemistry. Most mechanistic work on this problem has focused on single proteins with single functions; however, proteins often work as members of multi-functional, multi-protein complexes. How can evolution …
Patrick S. Ward · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $172,800 — PROJECT SUMMARY/ABSTRACT Excess adrenal steroid production is a prevalent but underdiagnosed etiology of hypertension and cardiovascular disease and poorly managed with current medical therapies. Diverse lines of complementary evidence point to dysfunction of adrenal mitochondrial redox pathways as …
FRANCISCO J BEZANILLA · UNIVERSITY OF CHICAGO · 2024 · $597,775 — Voltage sensing is found in many in biological processes and it is fundamental in excitable tissues. This project aims at understanding the physical bases of voltage sensing and how it acts on channel opening at the molecular level. We propose to find the structural basis of function with the follow…
Mikel Garcia-Marcos · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $387,375 — SIGNIFICANCE: G protein-coupled receptors (GPCRs) are a large family of membrane proteins that initiate cellular responses to a wide range of extracellular signals, like neurotransmitters or hormones, by activating heterotrimeric G proteins inside cells. This makes GPCRs critical for many physiologi…
GERARD VOCKLEY · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $544,348 — Disorders of the branched chain amino acid (BCAA) metabolism are the most common of the organic acidemias identified by newborn screening. The catabolism of leucine (LEU), isoleucine (ILE), and valine (VAL) begins through a set of common transporters and enzymes localized to the mitochondria. Therea…
Daniel Abate-Daga · H. LEE MOFFITT CANCER CTR & RES INST · 2024 · $224,506 — Project Summary Killer cell immunoglobulin-like receptors (KIR) are mainly expressed by NK cells, although their expression has also been described in CD4+, CD8+ and γδ T cells. Within CD8 T cells, KIR expression is induced at later stages of lymphocyte maturation and is thought to regulate specifi…
Donghun Shin · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $496,215 — ABSTRACT Biliary epithelial cells (BECs; also called as cholangiocytes) that line the hepatic biliary tree control bile composition and flow. Injury to the BECs leads to cholestasis, which can progress to fibrosis, cirrhosis and liver failure. Cholestatic liver diseases are associated with high morb…
Jeong H Yun · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $169,560 — Project Summary Chronic obstructive pulmonary disease (COPD), primarily caused by cigarette smoking, is the third leading cause of death in the United States. Remarkably, individuals with similar smoking histories have different susceptibility to develop the disease, and patients display a variable …
Eleen Yee Lam Shum · ENUMERIX, INC. · 2024 · $824,307 — PROJECT SUMMARY/ABSTRACT Enumerix has developed a cost-effective method to perform high order DNA counting at high precision called direct count PCR (dcPCR). dcPCR uses a spin column method that generates millions of partitions directly into PCR tubes for target amplification, using standard laborat…
Sally Nneoma Adebamowo · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $901,157 — Abstract/Summary Globally, non-communicable diseases (NCDs) outrank infectious diseases in terms of public health burden. Cardiometabolic diseases (CMD) such as heart disease and stroke are the leading causes of death worldwide. In this application we will explore the genomic risk for common CMD, in…
Peter The Sage · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $490,142 — Immunity to viral infections of the lung require cooperation between humoral and cellular arms of the immune system. A newly defined subset of CD8 T cell, called CXCR5+ CD8 T cells, have been identified. CXCR5+ CD8 T cells can gain access to the B cell follicle of lymph nodes and interact with B cel…
Susan H. Yoon · OHIO STATE UNIVERSITY · 2024 · $170,963 — PROJECT SUMMARY/ABSTRACT Susan Yoon, PhD, MSW, is a social scientist whose overarching career goal is to prevent substance use and improve health outcomes among vulnerable, at-risk youth by identifying key mechanisms for risk and resilience to adolescent substance use following child maltreatment. T…