Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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Xiaoling Li · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $3,007,589 — In the past year, our efforts focus on the role of SIRT1 and/or protein acylation in regulation of embryonic stem cell metabolism, differentiation, and animal development, and the impact of intestinal epithelial glucocorticoid signaling on intestinal inflammation, anti-tumor immunity, and tumorigene…
Peter Crompton · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $2,027,646 — Malaria caused by Plasmodium falciparum remains a major public health threat. Over 225 million cases of malaria occur annually among the world's poorest populations, claiming the lives of approximately 500,000 children each year in Africa alone. The widespread implementation of malaria control inter…
John Mascola · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $393,065 — During the past years, the Virology Laboratory has collaborated with other intramural NIAID labs and other external collaborators to develop a pseudovirus neutralization assay and an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). For the neutralization assay, w…
Richard Davey · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $3,113,196 — Novel means first to better characterize and then to treat infection with major respiratory pathogens using existing or newly developed strategies are a primary focus of this important project within the Clinical Research Section. In this regard, our Section has undertaken clinical research efforts …
Jeffrey Reece · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2021 · $607,097 — The mission of the National Institutes of Health (NIH) is to seek fundamental knowledge about the nature and behavior of living systems and to apply that knowledge to enhance health, lengthen life, and reduce illness and disability. As part of the NIH, the National Institute of Diabetes and Diges…
Marc Ferrer-Alegre · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2021 · $1,594,895 — We have established protocols for culturing primary human small airway epithelial cells and alveolar cells in a transwell air-liquid-interface (ALI) model. Tissue biofabrication has been optimized in a 96-well plate format, including the formation of a microvessel network. We are positioning these…
James Inglese · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2021 · $464,311 — This project includes the development of biochemical and target-focused assays based on specific protein or nucleic acid targets implicated in disease. The assay designs are considered in the context of analysis and progression strategies for evaluation of a wide range of compound classes using hi…
Marc Ferrer-Alegre · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2021 · $62,221 — We have established protocols for culturing primary human small airway epithelial cells and alveolar cells in a transwell air-liquid-interface (ALI) model. Tissue biofabrication has been optimized in a 96-well plate format, including the formation of a microvessel network. We are positioning these…
Matthew Wheeler · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $109,950 — With the increasing complexity of large datasets, the development of novel statistical techniques that can create informative analyses, which allow scientists and decision makers, to leverage the richness of the data source is needed. This research seeks to develop methodologies that extract meanin…
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $3,759,127 — The NIEHS Clinical Research Branch has continued to expand its scope of support for clinical and translational studies. The NIEHS Clinical Research Unit (CRU) has recorded over 11,000 patient encounters with over 95% patient satisfaction. Additional staff have been hired to support CRU functions. …
Eliezer Masliah · NATIONAL INSTITUTE ON AGING · 2021 · $57,874 — The main objective of the Molecular Neuropathology section (MNS) at Laboratory of Neurogenetics (LNG) is to harness the immune system to better understand the mechanisms of neurodegeneration and to develop therapies for synucleinopathies of the aging population such as DLB, PD and AD. We propose 3 A…
Jessica Manning · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $98,893 — METAGENOMIC CHARACTERIZATION OF SARS-COV-2 AND ITS VARIANTS AID CAMBODIAN PUBLIC HEALTH RESPONSE TO COVID19 PANDEMIC. NIAID Cambodia ICER quickly repurposed an existing metagenomics pipeline, originally set up for vector-borne diseases, to genetically characterize index cases of COVID-19 in January…
Leah Katzelnick · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $48,547 — We are collaborating with leaders of existing longitudinal cohort studies to: 1) Measure how preexisting immunity to endemic human coronaviruses and older SARS-CoV-2 variants modifies future risk of SARS-CoV-2 infection and COVID-19 disease in pediatric and adult populations, and 2) Prospectively tr…
ALEXANDER PLETNEV · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $16,970 — To achieve our goal, we generated a full-length infectious cDNA clone of SARS-CoV-2 coronavirus (isolate 2019-nCoV/USA_WA1/2020) and modified it for mouse model by introducing mouse-adapted mutations. In addition, using this cDNA we generated infectious clones for the three epidemiologically-signifi…
John Tsang · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $3,754,469 — In response to the SARS-CoV-2 pandemic we have made the technologies and platforms at CHI available for characterization of COVID-19 patient samples, as a priority ahead of our ongoing collaborative studies. Initially, acutely infected patients from northern Italy were characterized by multimodal hi…
William Elkins · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $10,368 — Transgenic animals: Using conventional transgenic approach, several transgenic lines were created for two independent projects, a) ACE2-GFP receptor and b) TMPRSS2 endothelial cell surface protein for Dr. Hickman. COVID-funding: A grant proposal submitted by MGGM was awarded $35,000 funding for th…
Ana Fernandez-Sesma · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $152,665 — The COVID-19 pandemic is the most important health challenge to the US population within a century. Most epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults. Inadequate information regarding the infection burden in children is available…
TED ROSS · UNIVERSITY OF GEORGIA · 2021 · $1,575,867 — The Georgia University Research Foundation to support the National Cancer Institute's multi-site study seeking to determine if immune responses developed after confirmed infection with SARS-CoV-2.…
Karla J F Satchell · NORTHWESTERN UNIVERSITY AT CHICAGO · 2021 · $790,318 — The goal of the Structural Genomics Centers for Infectious Diseases is to apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms…
TIMOTHY STEDMAN · AMERICAN TYPE CULTURE COLLECTION · 2021 · $667,054 — This contract provides unique and quality-assured infectious reagents and resources to the scientific community for use in basic research and product development. The scope of this contract includes the acquisition, authentication, production, preservation, storage, and distribution of research and …