Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Stefan Muljo · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $2,898 — We are taking an RNA-centric approach that aims to develop an RNA-based anti-COVID-19 drug. If we can successfully identify one or multiple miRNAs essential for viral life cycle, then these represent promising anti-viral targets, and could be immediately inhibited using therapeutic anti-sense techno…
D. Rebecca Prevots · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $107,030 — Enrollment in this study has been completed, with 1023 persons enrolled in 304 households, for an average household size of 3.4 persons per household. Preparation is underway to ship the samples to NIAID for IgG antibody testing. Households eligible for selection were those with at least one othe…
SANJAY A DESAI · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $50,010 — This is a new project undertaken this year based on identified knowledge gaps in the roles served by E protein in coronavirus infections. Because our laboratory has the required technologies, we have initiated the following specific aims within this project. AIM 1: Use electrophysiology to deter…
Jason Gall · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $5,963,191 — Coronavirus vaccines and protein reagents will be developed at the VPP. The vaccines may be manufactured through the VCMP for human clinical trials in compliance with current Good Manufacturing Practices (cGMP) and released for use in human clinical trials in healthy human volunteers. These vaccines…
Geoffrey Mueller · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $712,865 — I. Origins of Allergic Disease Over 100 million people worldwide suffer from birch pollen allergy. However, identification of molecular determinants driving the allergic responses to Bet v 1, the major birch pollen allergen, remains elusive. In collaboration with a group in Salzburg, Austria, we ex…
Adrian McDermott · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $2,371,299 — In March 2020 the VIP began working in collaboration with VRC laboratories on the trial readouts for the Phase 1 DIMID 20-003 trial. Later that year the VIP was working within the Operation Warp Speed (OWS) (now called Countermeasures Accelerations Group) testing USG identified CoVID-19 vaccines. T…
Genoveffa Franchini · DIVISION OF BASIC SCIENCES - NCI · 2021 · $4,206,398 — Accomplishments 1: Assess which macaque model better predicts or recapitulates the efficacy of HIV vaccine candidates in humans. The SIVmac251 model has predicted and recapitulated RV144: In 2005, a collaborative study in neonates predicted the results of RV144. More recently we recapitulated the ef…
MARC NICKLAUS · DIVISION OF BASIC SCIENCES - NCI · 2021 · $124,554 — In collaboration with several Principal Investigators at the CCR/NCI, in silico screening of large small-molecule databases are being conducted for a number of molecular targets relevant for cancer. We are using the CADD Group's resources, including our screening databases to generate lists of compo…
Barbara Lipska · NATIONAL INSTITUTE OF MENTAL HEALTH · 2021 · $3,811,597 — Currently, the Human Brain Collection Core (HBCC) has 1238 brains available for distribution, with the following diagnoses (numbers of subjects listed in parentheses): attention deficit disorder (21); anxiety disorders (25); autism spectrum disorders (3); Bipolar disorder (156), Non-psychiatric cont…
Daniel Levy · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $3,323,367 — As part of the Population Sciences Branch (PSB), the Levy Lab conducts genetic and multidimensional omics research focused on cardiovascular disease (CVD) and its risk factors. Two important areas of the Levy Lab's intramural research are: 1) blood pressure (BP) genetics 2) multidimensional omics o…
Robert Sills · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $2,147,476 — The goals and accomplishments during the past year are listed below. Meetings with various NIEHS investigators and staff for project set-up and coordination of project flow. Evaluation of embryos, placentae and implantation sites for gross lesions at select time points for abnormal phenotypes. Gene…
RICHARD DOUGLAS FIELDS · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2021 · $1,436,963 — Our long-standing interest is in neural plasticity, but we are especially interested in the involvement of glial cells in nervous system development, learning & cognition. Glia are brain cells that do not fire electrical impulses, but they communicate by releasing neurotransmitters. This enables g…
JAMES C MULLIKIN · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · 2021 · $9,768,240 — Over the last year, NISC operated the following suite of production sequencing machines: 1 PacBio Sequel 2, 1 NextSeq 550, 1 NovaSeq 6000, and 3 MiSeqs. Using these platforms, we have generated over 1,773 billion reads in the past year. Though we remain consistently at a level of a mid-scale ge…
Nirav Rati Bhakta · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $1,009,218 — PROJECT SUMMARY/ABSTRACT COVID-19, the pandemic illness caused by the novel virus SARS-CoV-2, is a serious respiratory illness that has high infectivity and a mortality rate that varies from <1% to up to 20% depending on underlying risk factors. Indeed, disease severity varies markedly based on reco…
CALVIN J KUO · STANFORD UNIVERSITY · 2021 · $410,250 — PROJECT SUMMARY (Core B: Organoid Core) Infectious disease research is substantially hampered by lack of experimental models necessary to study interactions between pathogens and target tissues; a glaring deficiency amplified by the recent COVID-19 pandemic. The recent advent of 3D organoid methods …
TIMOTHY STEDMAN · AMERICAN TYPE CULTURE COLLECTION · 2021 · $1,000,590 — This contract provides unique and quality-assured infectious reagents and resources to the scientific community for use in basic research and product development. The scope of this contract includes the acquisition, authentication, production, preservation, storage, and distribution of research and …
TIMOTHY STEDMAN · AMERICAN TYPE CULTURE COLLECTION · 2021 · $11,000,208 — This contract provides unique and quality-assured infectious reagents and resources to the scientific community for use in basic research and product development. The scope of this contract includes the acquisition, authentication, production, preservation, storage, and distribution of research and …
TOM DENNY · DUKE UNIVERSITY · 2021 · $2,307,858 — The mission of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is to increase basic knowledge of the pathogenesis and transmission of the human immunodeficiency virus (HIV), support the development of therapies for HIV…
Karla J F Satchell · NORTHWESTERN UNIVERSITY AT CHICAGO · 2021 · $608,299 — The goal of the Structural Genomics Centers for Infectious Diseases is to apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms…
PETER MYLER · SEATTLE CHILDREN'S HOSPITAL · 2021 · $561,070 — The goal of the Structural Genomics Centers for Infectious Diseases is to apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms…