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Principal Investigator: Robert Sills
Organization: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Fiscal Year: 2021
Award: $2,147,476
Funding agency: National Institute of Environmental Health Sciences
The goals and accomplishments during the past year are listed below.
Meetings with various NIEHS investigators and staff for project set-up and coordination of project flow.
Evaluation of embryos, placentae and implantation sites for gross lesions at select time points for abnormal phenotypes.
Generation of gross findings report of embryo collections including photo documentation and genotyping results.
In-utero and in-decidua embryo collection/dissection.
Individual organ dissection from embryo (depending on age).
Tail collection for embryo genotyping (tissue specific at different gestational ages).
Age specific processing schedules and fixation methods of embryos and agar/paraffin embedding.
Embryo sectioning at various planes, with step or serial sectioning, depending on project.
Staining of slides with histological evaluation of embryos at select time points and postnatal animals as needed.
Generation of histopathology report and histopathology slide review with investigators and staff.
This project involves research on human coronavirus, novel coronavirus, COVID-19, Severe Acute Respiratory Syndrome coronavirus disease, SARS coronavirus, SARS-coronavirus-2, SARS-cov-2, SARS-cov2, SARS-related coronavirus 2, Severe acute respiratory syndrome coronavirus 2, SARS-Associated Coronavirus, SARS-cov, or SARS-Related Coronavirus.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Agar><Age><Animals><Body Tissues><COVID-19><COVID-19 virus><COVID19><COVID19 virus><CV-19><CV19><Cells Placenta-Tissue><Chronologic Fetal Maturity><CoV emergence><CoV-2><CoV2><Collection><Decidua><Decidua Graviditas><Dissection><Documentation><Embryo><Embryonic><Evaluation><Fetal Age><Fixation><Generations><Genotype><Gestational Age><Goals><HCoV><Histologic><Histologically><Histopathology><Individual><Investigators><Laboratories><Lesion><Methods><Mice><Mice Mammals><Microscopic><Murine><Mus><NIEHS><National Institute of Environmental Health Sciences><Normal Placentoma><Organ><Paraffin Embedding><Pathologic><Pathology><Phenotype><Placenta><Placenta Embryonic Tissue><Placentome><Reporting><Research><Research Personnel><Researchers><SARS><SARS Virus><SARS corona virus><SARS corona virus 2><SARS coronavirus><SARS coronavirus disease><SARS-Associated Coronavirus><SARS-CoV><SARS-CoV disease><SARS-CoV-2><SARS-CoV2><SARS-Related Coronavirus><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Schedule><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome Virus><Severe Acute Respiratory Syndrome corona virus><Severe Acute Respiratory Syndrome coronavirus><Severe Acute Respiratory Syndrome coronavirus disease><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Site><Slide><Staining method><Stains><Tail><Techniques><Time><Tissues><Wuhan coronavirus><ages><corona virus disease 2019><corona virus emergence><coronavirus disease 2019><coronavirus disease 2019 virus><coronavirus emergence><emergent CoV><emergent corona virus><emergent coronavirus><emerging CoV><emerging corona virus><emerging coronavirus><flexibility><flexible><hCoV19><human CoV><human corona virus><human coronavirus><implantation><in utero><meetings><nCoV><nCoV2><new CoV><new corona virus><new coronavirus><novel CoV><novel corona virus><novel coronavirus><postnatal><sample collection><sample fixation><severe acute respiratory syndrome-CoV><specimen collection>