Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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Robert J. Emery · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2020 · $98,444 — ABSTRACT The Texas-Utah Consortium will address an immediate and critical need to prevent or reduce occupational exposure to the SARS-CoV-2 virus. Composed of dedicated experts in medicine, public health, industrial hygiene, epidemiology and education, the Texas-Utah Consortium advances the National…
JOHN I GALLIN · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $256,927 — Results: (1) Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by mutations in the multicomponent NADPH oxidase (phagocyte oxidase, NOX2) complex. During the past FY, through collaboration with the Neutrophil Monitoring Laboratory (NML) managed by Douglas Kuhns, PhD (Leidos, …
Harry L Malech · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $669,910 — This project is focused on developing curative allogentic HSC transplants and autologous HSC gene therapies for primary immune deficiencies (PIDs) and primary immune regulatory disorders (PIRDs). Our laboratory program is designed to facilitate the translation of our laboratory efforts into therapeu…
Daniella Schwartz · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $17,021 — In FY2020, we initiated this project and began exploring the responses of T cells from patients with MIS-C, using cells from age-matched subjects with acute SARS-CoV2 infection and age-matched healthy volunteers as comparators. Because of the exploratory nature of the project and extremely recent st…
Hans Ackerman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $44,930 — This project is part of NIAID intramural basic science research response to the COVID-19 pandemic. The SARS-CoV-2 coronavirus which causes COVID-19 enters cells through binding with angiotensin converting enzyme 2 (ACE2). Two common medications- ACE inhibitors (ACEi) and angiotensin receptor blocker…
William Copeland · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $196,477 — Deployment of a SPA pipeline to determine the structure of S-protein soluble ectodomain and its complexes: We have established high-throughput structure determination workflows using single particle analysis cryo-EM (SPA). These workflows are capable of solving the structure of macromolecular comple…
Robert Best · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2020 · $866,673 — The project has addressed the following areas in the past year: 1. Studies of SARS-Cov2 Main Protease. In collaboration with John Louis (NIDDK), we have investigated the autoprocessing mechanism of the SARS-Cov2 Main Protease. A reaction coordinate was developed that can describe the conformational…
Betsey Herpin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $21,635,765 — The Office of Clinical Research Policy and Regulatory Operations (OCRPRO) supported the conduct of 224 active clinical trials in FY20 from 24 NIAID laboratories and other clinical research projects by providing an array of services to ensure that FDA and other DHHS regulations were fulfilled includi…
Susan Elmore · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $1,401,493 — The goals and accomplishments during the past year are listed below. Meetings with various NIEHS investigators and staff for project set-up and coordination of project flow. Evaluation of embryos, placentae and implantation sites for gross lesions at select time points for abnormal phenotypes. Gene…
Xin Wei Wang · DIVISION OF BASIC SCIENCES - NCI · 2020 · $691,685 — In collaboration with Luigi Notarangelo, MD, Irini Sereti, MD and Andrea Lisco, MD, PhD of NIAID, we are working to determine the landscape of viral exposure signature as the humoral immunological responses to the history of viral infection in COVID-19-positive patients using the VirScan platform. W…
robert a heinzen · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $352,348 — Coxiella burnetii is a ubiquitous zoonotic bacterial pathogen and the cause of human acute Q fever, a disabling influenza-like illness. Coxiella's former obligate intracellular nature significantly impeded genetic characterization of putative virulence factors. However, our seminal advance of host c…
Jessica Manning · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $615,967 — METAGENOMIC SEQUENCING OF EMERGING DISEASES NIAID Cambodia ICER quickly repurposed an existing metagenomics pipeline, originally set up for vector-borne diseases, to genetically characterize index cases of COVID-19 in January 2020. At this early pre-pandemic timepoint, sequencing COVID-19 cases wa…
Leesa Deterding · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $1,064,280 — We have analyzed a variety of molecules obtained from various sources to get the quantitative information. Additionally, we are developing methods to improve the quantitative information that can be gained. 1. Method Development. The use of label-free and labeling approaches for quantitative proteom…
Alex Compton · DIVISION OF BASIC SCIENCES - NCI · 2020 · $199,245 — This project was initiated in spring of 2020 and is now in the preparatory phase. We have obtained CRISPR-Cas9 libraries from Juan Bonifacino that can be delivered to diverese cell types by lentiviral vectors. We have applied lentiviral vectors carrying CRISPR-Cas9 libraries to HeLa, Vero, and HEK29…
James Pickel · NATIONAL INSTITUTE OF MENTAL HEALTH · 2020 · $3,276,800 — The NIMH transgenic core facility has several major functions: 1) to produce transgenic research animals for neuroscience research, 2) to develop new transgenic techniques and model systems, and 3) to engage in collaborative projects that promote genetic approaches to neuroscience research. 1) Prod…
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $66,415 — Emerging/re-emerging zoonotic diseases are a major global health problem. Linking comprehensive pathogen surveillance of arthropod/vector populations in Uganda with public health surveillance at the regional and international level will make an important contribution to human and animal health in Ea…
Mary Smolskis · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $5,310,817 — The NIAID Division of Clinical Research (DCR) rapidly deployed resources to support collaborative clinical research. In support of multiple COVID-19 clinical trials, the DCR Integrated Research Facility at Fort Detrick, MD provided testing of plasma, serum, and purified antibodies for neutralizatio…
Mitchel A Rosen · RBHS-SCHOOL OF PUBLIC HEALTH · 2020 · $25,850 — Abstract The New Jersey / New York Hazardous Materials Worker Training Center will provide training for essential works to respond and work safely when faced with exposure to COVID-19. The Center will provide train-the-trainer course via distance web conferencing to expand the knowledge of trainers …
DAVID TURCOTTE · UNIVERSITY OF MASSACHUSETTS LOWELL · 2020 · $86,307 — Program Summary/Abstract This is a supplemental proposal for a coronavirus and infectious disease response training program to be implemented by The New England Consortium-Civil Service Employees Association (TNEC-CSEA), a partnership between the University of Massachusetts Lowell (UML), four New En…
Hanno Steen · BOSTON CHILDREN'S HOSPITAL · 2020 · $2,174,014 — Project Summary/Abstract In Dec 2019, a cluster of respiratory illness in Wuhan China defined the onset of a worldwide pandemic involving a novel coronavirus (SARS-CoV-2). SARS-CoV-2 infected patients are frequently asymptomatic, but initial epidemiologic estimates from the WHO indicate that ~15% of…