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9873 documents

Reducing Drug-Related Mortality Using Predictive Analytics: A Randomized, Statewide, Community Intervention Trial

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Magdalena Cerda · BROWN UNIVERSITY · 2020 · $168,548 — The COVID-19 pandemic is colliding with the ongoing drug overdose epidemic, a public health crisis that has taken over 750,000 lives in the United States over the past two decades. The pandemic and associated policy responses will have lasting impacts of the lives of people at risk for overdose. Mor…

Cancer Center Support Grant Supplement: Clinical Evaluation of a Q GRFT Nasal Spray for Prevention of SARS-CoV-2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Robert L. Ferris · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $1,197,257 — The current approaches of using protective barriers, social distancing and increased hand hygiene to prevent SARS-CoV-2 transmission have economic consequences and variable efficacy at reducing the spread of SARS-CoV-2. Therefore, curtailing the acquisition of SARS-CoV-2 infection via chemoprophylac…

Rho Federal Systems Division, Inc. NIAID DAIT SACCC

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Samuel Arbes · RHO FEDERAL SYSTEMS DIVISION, INC. · 2020 · $10,601,507 — PROJECT SUMMARY / ABSTRACT COVID-19, the infectious disease caused by SARS-CoV-2, is rapidly affecting humans around the globe. While initial epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults, little information regarding the infecti…

IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC): Clinical and Data Coordinating Center (CDCC)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

OFER LEVY · BOSTON CHILDREN'S HOSPITAL · 2020 · $2,426,447 — IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC): Clinical and Data Coordinating Center (CDCC) Project summary In December 2019, a cluster of respiratory illness in Wuhan, China defined the onset of a global pandemic involving a novel coronavirus (SARS-CoV-2) with associated respiratory di…

RADx-UP CDCC

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Michael Cohen-Wolkowiez · DUKE UNIVERSITY · 2020 · $20,162,334 — ABSTRACT There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To address this need the Rapid Acceleration of Diagnostics for Underserved Popu…

An ELISA and homogeneous assay for serological diagnosis of SARS-CoV2 antibodies

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Feifan Yu · ALPHATHERA, INC. · 2020 · $119,588 — The speed and extent of COVID-19 pandemic, caused by the SARS-CoV2 virus, have created unprecedented devastations and challenges. It is now well-established that timely and accurate diagnosis is essential to taming this pandemic. Unlike PCR based tests, which can only diagnose active infections, ser…

Center for Clinical and Translational Science

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Robert P. Kimberly · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $587,941 — ABSTRACT The pandemic prompted by the novel SARS-COV-2 virus continues to have a devastating impact on the health of communities, clinically, socially and economically. Preventive approaches require an understanding of the virus prevalence and herd immunity in the general population. To evaluate the…

Provision of Clinical Data to Support a Nationwide COVID-19 Cohort Collaborative

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Donald E Brown · UNIVERSITY OF VIRGINIA · 2020 · $50,000 — The unknown and changing characteristics of the SARS-CoV-2 pandemic have severely challenged the United States (U.S.) health care systems. The key to addressing many of these challenges is data and information sharing. To do this requires bringing together individual level health data from disparate…

URBAN ARCH (5/5) Boston Cohort - Alcohol and HIV-associated comorbidity and complications: Frailty, Functional impairment, Falls, and Fractures (the 4F study)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Timothy C. Heeren · BOSTON UNIVERSITY MEDICAL CAMPUS · 2020 · $163,640 — This proposal is an urgent competitive revision designed to supplement an existing NIH-funded study to assess the impact of the COVID-19 pandemic on alcohol and other drug use, and medication adherence that is critical for preventing HIV disease progression, among people living with HIV (PLWH). The …

Significant expansion of the SNPRC ABSL3 capability in the wake of COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Larry S. Schlesinger · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2020 · $2,000,000 — Research Summary/Abstract. The SNPRC is one of seven NIH supported National Primate Research Centers. The center receives additional support from the sponsor organization, Texas Biomedical Research Institute. The center and the institute have a very strong focus on biomedical research involving infe…

University of Pittsburgh Clinical and Translational Science Institute

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

STEVEN E REIS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $750,000 — ABSTRACT The pandemic prompted by the novel SARS-COV-2 virus continues to have a devastating impact on the health of communities, clinically, socially and economically. Preventive approaches require an understanding of the virus prevalence and herd immunity in the general population. To evaluate the…

EPPIC-NET DCC - Revision

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Eva Petkova · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $1,333,195 — The Data Coordinating Center (DCC) of the Early Phase Pain Investigation Clinical Network (EPPIC-Net) will be the data and biospecimen manager for pain research within the HEAL Partnership. As such, it will host, manage, standardize, curate, and provide a sharing platform for data and biospecimens f…

HIV/AIDS Clinical Trials Unit (CTU) COVID-19 Admin Supplement

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Joseph J Eron · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $600,000 — Project Summary/Abstract The University of North Carolina (UNC) Global HIV Clinical Trials Unit (CTU) has a well established track record of high-quality, innovative clinical research, strong scientific leadership (both in and outside the NIH HIV/AIDS Networks), and access to critically important in…

Pittsburgh Girls Study: Substance Use and HIV Risk Behaviors/STI in Young Adulthood

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Tammy Chung · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · 2020 · $132,008 — ABSTRACT This 1-year supplement to the Pittsburgh Girls Study (PGS), a large longitudinal community study of young adult women, will capture urgently needed data on factors at individual (e.g., smoke or vape tobacco/nicotine, cannabis), social (family, peer), and neighborhood (e.g., perception of ne…

Nonhuman Primate Reagent Resource

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Kathleen Engelman · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $353,732 — U24 AI126683 – Parent Award Abstract Nonhuman primates (NHPs) serve a crucial role in translational research as animal models for exploring the pathogenesis of infectious and noninfectious diseases, and for testing of biologic therapies and vaccines. While many human diagnostic immunologic reagents …

Coronavirus and Infectious Disease Response Training

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

DAVID TURCOTTE · UNIVERSITY OF MASSACHUSETTS LOWELL · 2020 · $131,566 — Program Summary/Abstract This is a supplemental proposal for a coronavirus and infectious disease response training program to be implemented by The New England Consortium-Civil Service Employees Association (TNEC-CSEA), a partnership between the University of Massachusetts Lowell (UML), four New En…

Deciphering the RNA Biology of SARS-CoV-2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Stefan Muljo · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $27,488 — We are taking an RNA-centric approach that aims to develop an RNA-based anti-COVID-19 drug. If we can successfully identify one or multiple miRNAs essential for viral life cycle, then these represent promising anti-viral targets, and could be immediately inhibited using therapeutic anti-sense techno…

COVID Support from the IDPS to NIAID Investigators

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

William Elkins · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $57,413 — Since April, the IDPS has received and processed lung samples from approximately 300 mice and 100 NHPs, respectively. The data generated, therein, helped move the ongoing clinical studies forward to Phase III clinical trials and, at the same time, resulted in the submission and publication of these…

Inflammatory and immune dysregulation associated lung disease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Kenneth Olivier · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2020 · $289,215 — The pulmonary involvement in disorders of immune or inflammatory regulation can range from a primary manifestation such as with sarcoidosis or a relatively minor manifestations such as seen with the Mendelian Susceptibility to Mycobacterial Disease immune deficiencies. While both of these can be as…

Sensory Science and Metabolism; Molecular and Neuronal Mechanisms

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Paule Joseph · NATIONAL INSTITUTE OF NURSING RESEARCH · 2020 · $661,047 — The Sensory Science and Metabolism (SenSMet) laboratory at NINR/NIAAA conducts translation and clinical inpatient and outpatient studies. Active collaborations to investigate areas of common interest in nutrition, taste, and obesity have been undertaken. Specifically, double-blind clinical protocols…