Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Alan Koretsky · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2020 · $1,718,993 — We have made substantial progress towards Aims 1-5 and 8. Specifically: a) We have determined that 3 nm iron oxide nanoparticles can be reliably fabricated, in collaboration with the NIH image probes development core. These serve as good T1 MRI contrast agents and have strong T2* contrast…
Nadine Samara · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2020 · $750,000 — GalNAc-Ts initiate mucin-type O-glycosylation by transferring N-acetylgalactosamine (GalNAc) from UDP-GalNAc to Thr/Ser acceptors on protein substrates such as mucins. These enzymes do not recognize a consensus sequence or motif and each isoenzyme shows unique specificity towards acceptor sites on a…
Daniel Menendez Rendon · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $17,940 — p53 is central to human DNA repair, damage checkpoints and many aspects of human biology. Most cancers are altered for p53 function. Although the guardian of the genome p53 has been extensively studied, much about its function and its targets remains unknown. IDENTIFYING p53 TARGETS. Identifying the…
Clarice Weinberg · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $534,584 — This project develops new statistical methods for epidemiology with broad applications and also methods as needed for ongoing projects in epidemiology, particularly those related to reproductive studies. The work this year involved seven main projects. (1) Pooling was recommended as a way to improv…
Manas Ray · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $1,576,166 — The NIEHS knock out core (KOC) is a service orientated facility, which aims at helping investigators at NIEHS develop animal models to further their research and fulfilling the mission statement of NIEHS. The KOC aids investigators in generating transgenic mouse models specific for their research ne…
Frank Maldarelli · DIVISION OF BASIC SCIENCES - NCI · 2020 · $591,239 — Fundamental gaps in our understanding of HIV reservoirs preclude a precisely targeted approach to eradication. HIV is neither eliminated nor often controlled by the human immune system, and the immunologic defect(s) responsible for this lack of control are unknown. We are conducting several studies …
Jennifer Jones · DIVISION OF BASIC SCIENCES - NCI · 2020 · $163,683 — Specific Aim 1: Test NCI Translational Nanobiology technologies for use in the study of SARS-CoV2 and COVID-19. By utilizing a BSL-2+ area for NIH N-VITA studies in the NINDS Viral Immunology Section, and by testing specialized tools and methods developed in the NCI Translational Nanobiology Section…
robert a heinzen · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $947,280 — Central to Q fever pathogenesis is replication of the causative agent, Coxiella burnetii, in a large and spacious phagolysosome-like Coxiella-containing vacuole (CCV). Similar to a phagolysosome, the CCV has an acidic pH and contains lysosomal hydrolases obtained via fusion with late endocytic vesic…
John Mascola · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $253,477 — During the past year, the Virology Laboratory has collaborated with other intramural NIAID labs and other external collaborators to develop a pseudovirus neutralization assay and an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). For the neutralization assay, we…
Nicole Y Morgan · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2020 · $200,000 — The use of microfabricated and microfluidic structures in biomedical research has been rapidly expanding in recent years, but many research applications of these devices require customization, and new applications typically require several design iterations for troubleshooting. In an effort to bring…
Lars Pedersen · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $1,453,130 — Our lab works on a variety of different biological systems including heparan/chondroitin sulfate biosynthesis, DNA replication/repair, nuclear receptors, folate metabolism, and antibody/antigen interactions. Listed below are a few of our main projects form last year: 1) Work on glycosylaminoglycan…
Marc Ferrer-Alegre · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2020 · $711,776 — We have made significant progress on several of our goals and objectives listed above over the past few months. Accomplishments are written according to objective number. 1. We have established optimized protocols for culturing primary human small airway epithelial cells and alveolar cells in a tra…
D. Rebecca Prevots · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $334,313 — To date the study has not started enrollment yet. We have designed a questionnaire and data entry system. The questionnaire is being piloted and recruitment strategies are being discussed. A rapid reporting system is being established to refer confirmed cases from the Social Security to study pers…
Karran Phillips · NATIONAL INSTITUTE ON DRUG ABUSE · 2020 · $1,253,916 — The Office of the Clinical Director (OCD), Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), NIH provides clinical research support to three clinical research branches, the Clinical Pharmacology and Therapeutics Research Branch (CPTRB), the Translational Addiction Medicine …
Olivia Steele-Mortimer · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $356,012 — Live recombinant attenuated Salmonella vaccines (RASV) have been used to protect against Typhoid fever and can be used to deliver foreign antigens or DNA plasmids. We are developing an RASV platform as a therapeutic vaccine for breast cancer and also as a delivery system for DNA antiviral vaccines. …
PETER MYLER · SEATTLE CHILDREN'S HOSPITAL · 2020 · $1,629,697 — The goal of the Structural Genomics Centers for Infectious Diseases is to apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms…
ANBU DEVASAHAYAM · EMINENT SERVICES CORPORATION · 2020 · $169,228 — The Clinical Product Center under contract, provides Investigational Product Services for all DAIT-funded and/or sponsored clinical research programs and other NIAID-funded clinical trials as needed. Studies to be supported encompass a broad range of immune-mediated & rare diseases, including: (i) a…
RANDI HORNBACK · BATTELLE CENTERS/PUB HLTH RES & EVALUATN · 2020 · $814,926 — The Evaluation and Testing Services (ETS) for Vaccines and Other Biologics for Infectious Diseases contract provides a variety of product development services from early feasibility studies through manufacture of Phase I/II material, including assay development; immunogenicity and efficacy testing; …
MARK A. ATKINSON · UNIVERSITY OF FLORIDA · 2020 · $1,351,492 — Extensive clinical research studies are urgently needed to inform patient management strategies and develop pharmaceutical countermeasures to combat the 2019 novel coronavirus disease (COVID-19). Currently, COVID-19 infections and hospitalizations are surging across the state of Florida; hence, we p…
Emma Fernandez-Repollet · UNIVERSITY OF PUERTO RICO MED SCIENCES · 2020 · $187,497 — Project Summary/Abstract: Among patients with COVID19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury as a result of the infection (22% of critically ill patients). COVID19 may disproportionately affect people with cardiovascular disease. Previ…