Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
STEVEN A BENNER · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · 2022 · $741,716 — Basic Research to Diagnostics and Surveillance in Lower Resource Environments Foundation for Applied Molecular Evolution Steven A. Benner ABSTRACT We will deliver to the NIAID and CDC communities, through basic research, a scientific understanding of pairing, mispairing, and enzymology of natural …
Kelly Doran · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $802,854 — PROJECT SUMMARY Over 1.4 million people experience homelessness in the U.S. each year. A large body of evidence has demonstrated the bidirectional relationship between homelessness and substance use (SU), and overdose is the leading cause of death among people experiencing homelessness. The COVID-19…
Peter Daszak · ECOHEALTH ALLIANCE, INC. · 2022 · $653,392 — 1 Two major coronaviral diseases of wildlife origin have emerged in Asia in the last two decades. Both likely 2 began as zoonotic spillover events, leading to small case clusters, but were not identified until significant 3 community spread made control difficult, and in the case of COVID-19, led …
Minolfa C Prieto · GORDON RESEARCH CONFERENCES · 2022 · $40,000 — PROJECT SUMMARY The renin angiotensin aldosterone system (RAAS) is a key regulator of cardiovascular (CV) function, fluid electrolyte balance, and homeostasis, and it influences many systems including the renal, neuroendocrine, and immune systems. Perturbations of the RAAS trigger a cascade of event…
Gary Fujii · MOLECULAR EXPRESS, INC. · 2022 · $298,479 — Project Summary The principal goal of this project is to demonstrate that the FDA-approved anthelminthic drug, niclosamide, can be reformulated in a synthetic lung surfactant which can be aerosolized for the treatment of infections caused by respiratory viruses. The studies proposed in this SBIR Ph…
David M Koelle · UNIVERSITY OF WASHINGTON · 2022 · $220,624 — Summary The acquired, antigen-specific immune response to SARS-CoV-2-infection is likely central to determining the outcome of COVID-19 and the efficacy and durability of vaccination. CD4 T cell help is required for lasting, avid antibody responses. The leading vaccine candidates include some format…
Jonathan L Zelner · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $679,307 — Project Summary/Abstract The distribution of disease and death from the COVID-19 pandemic has been grossly unequal in every dimension. The vaccination campaign, throughout Winter and Spring 2021, has seen these inequities repeated. Lower-risk, wealthier, and Whiter individuals have received earlier …
Ruili Huang · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $502,225 — The Tox21 Programs federal partners include the Environmental Protection Agency (EPA), the Food and Drug Administration (FDA) and NIH, with leadership from NCATS and the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS). These agencies work together…
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $685,603 — The Environmental Polymorphisms Registry (EPR), now called Personalized Environment and Genes Study (PEGS) of over 17,000 participants provides a unique resource for a variety of studies dedicated to clarifying the interaction of genetic and environmental determinants of human health. The PEGS's sub…
ALEXANDER PLETNEV · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $675,862 — The pathogenesis of flaviviral neuroinfection is complex and depends on a series of events involving (1) virus replication in the periphery to produce and sustain the level of viremia sufficient for neuroinvasion, (2) virus entry into the CNS (neuroinvasiveness), (3) virus replication, spread, and i…
Marc Ferrer · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $90,219 — We have established protocols for culturing primary human small airway epithelial cells and alveolar cells in a transwell air-liquid-interface (ALI) model. Tissue biofabrication has been optimized in a 96-well plate format, including the formation of a microvessel network. We are positioning these…
Richard Davey · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $3,483,874 — Novel means first to better characterize and then to treat infection with major respiratory pathogens using existing or newly developed strategies are a primary focus of this important project within the Clinical Research Section. In this regard, our Section has undertaken clinical research efforts …
William Elkins · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $28,533 — COVID 19 related projects: Humanized animals: Using CRISPR/cas9 mediated gene KI via specific gRNAs and ODNTs, several lines have been created with the human ACE2 mutations individually in exons #2, exon #3 and exon #9. In the second stage, the sperm from these lines was used to create embryos tha…
Iyadh Douagi · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $495,304 — The project particularly aims to use state of the art instrumentation to support the immediate research needs for COVID19 research in flow cytometry. We are interested in developing new capacities for high-dimensional cell sorting requiring the precise identification of rare cell subsets based on m…
Keir Neuman · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $1,567,748 — Research in Progress The first project is focused on elucidating mechanistic details of the interaction between type II topoisomerases and DNA. One aspect of this interaction concerns the ability of type II topos to relax the topology of DNA to below equilibrium values. In vivo, these topoisomerases…
Xiaoling Li · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $3,474,264 — In the past year, our efforts focus on the role of SIRT1 and/or protein acylation in regulation of embryonic stem cell metabolism, differentiation, and animal development, and the impact of intestinal epithelial glucocorticoid signaling on intestinal inflammation, anti-tumor immunity, and tumorigene…
Scott Auerbach · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $4,764,641 — Core Key Area 1. Our work provides researchers with computational resources needed for analytical work and tool development. 2. Delivered goals included: a. Deployment of RStudio Connect to support deployment of visual-analytics tools. b. Support for data processing pipelines using Knime softw…
NICO TJANDRA · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $1,309,932 — As a progression in developing new technology to characterize dynamic molecular events which regulate important biological function, we chose to look at retroviral capsid assembly. This protein is a part of the Gag-poly protein which is processed as part of the maturation of the virus. The assembly …
MARC NICKLAUS · DIVISION OF BASIC SCIENCES - NCI · 2022 · $180,592 — In collaboration with several Principal Investigators at the CCR/NCI, in silico screening of large small-molecule databases are being conducted for a number of molecular targets relevant for cancer. We are using the CADD Group's resources, including our screening databases to generate…
Hongtao Yu · MORGAN STATE UNIVERSITY · 2022 · $271,599 — PROJECT SUMMARY The goal of this HIV/HCV/COVID-19 supplement project is to expand the original study cohort for studying (1) the feasibility of and barriers to achieving HCV elimination among people living with HIV (PLWH) and people at risk of HIV (PARH) through linkage to HIV care and prevention an…