NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Patricia Veronica Aguilar · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $300,959 — Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
JOANN M TUFARIELLO · GEORGIA STATE UNIVERSITY · 2021 · $31,000 — Summary This developmental project seeks to develop methods to dramatically boost immunogenicity of virus-like particle (VLP) vaccines. Ebola virus (EBOV) and Marburg virus (MARV) are members of the filovirus family of enveloped, negative-sense RNA viruses that causes outbreaks of severe human disea…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Jae U Jung · CLEVELAND CLINIC LERNER COM-CWRU · 2021 · $604,163 — Project Summary/Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) listed in the World Health Organization 9 most dangerous pathogens is an emerging Phlebovirus in the Phenuiviridae family. Due to the lack of therapy and vaccine against SFTSV infection, there is a pressing need to u…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
ROBERT A DAVEY · PURDUE UNIVERSITY · 2021 · $621,031 — A research team from Purdue University and Texas Biomedical Research Institute is in pursuit of important new approaches to validate the host V-ATPase. The project goal to define antiviral drug leads for diseases caused by Ebola and Marburg filoviruses. Many viral pathogens bind to specific factors …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Christopher F Basler · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $770,311 — Project Summary Filoviruses, which include the ebolaviruses and marburgviruses, are non-segmented, negative-sense RNA viruses (NNSVs) that cause severe human disease. These viruses are of concern as emerging pathogens and as potential bioterrorism threats. Their importance and public health impact a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Thomas William Geisbert · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2021 · $1,144,444 — Abstract Among viruses that cause disease in humans the henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), stand out for their impressive lethality. These viruses are among the most deadly human pathogens known to man with case fatality rates averaging about 75% for NiV. Significantly, there i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2021 · $1,591,689 — The mission of the CCR LGI Flow Cytometry Core in Building 37 (FC37) is to offer up-to-date instrumentation and technical expertise to CCR investigators to assist cancer research. The core provides full-scale, state-of-the-art flow cytometry services including analytical sample acquisition, data ana…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $2,542,134 — PROJECT SUMMARY/ABSTRACT – BSL-4 Evaluation Core (Core B) Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Kevin Michael Tuohey · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $1,916,666 — Core 3: Environmental Health and Biosafety Regulations and Requirements Abstract The Environmental Health and Biosafety Regulations and Requirements (EHBRR) Core includes three components: Environmental Health and Safety, Emergency Management, and Occupational Medicine. The Core is integrated with c…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Yi Zeng · UNIVERSITY OF ARIZONA · 2021 · $154,591 — Project Summary / Abstract: Flow Cytometry Shared Resource (FCSR) The goal of the Flow Cytometry Shared Resource (FCSR), which has served investigators of the University of Arizona Cancer Center (UACC) for more than 25 years, is to offer UACC Members efficient and reliable flow cytometric service…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2021 · $4,765,823 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $7,043,167 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
JOANN M TUFARIELLO · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $230,538 — Summary This developmental project seeks to develop methods to dramatically boost immunogenicity of virus-like particle (VLP) vaccines. Ebola virus (EBOV) and Marburg virus (MARV) are members of the filovirus family of enveloped, negative-sense RNA viruses that causes outbreaks of severe human disea…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Colleen B Jonsson · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2021 · $3,211,742 — Project Summary The University of Tennessee Health Sciences Center (UTHSC) proposes to upgrade facilities and broaden research services in the existing UTHSC Regional Biocontainment Laboratory (RBL) located in Memphis, TN to support internal and external investigators in basic and translational rese…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
KENNETH E PALMER · UNIVERSITY OF LOUISVILLE · 2021 · $3,333,333 — The University of Louisville Regional Biocontainment Laboratory (RBL) is an operational unit of the University’s Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The CPM operates the only Biosafety Level 3 laboratories and animal research facilities available t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Jay Kenneth Fisher · REDBUD LABS, INC. · 2021 · $291,649 — ABSTRACT We propose to develop a point-of-need system for differential molecular identification of filoviruses from syndromically similar infections. Our goal is to enable rapid, sensitive, and specific identification of quarantinable infections to reduce nosocomial risk and improve outbreak respons…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Gregg A Dean · COLORADO STATE UNIVERSITY · 2021 · $214,464 — Contact PD/PI: Dean, Gregg A. Infectious Disease Research and Response Training Program (IDRRTP) The Infectious Disease Research and Response Network (IDRRN) was established in 2016 and has been recognized as a Program of Research and Scholarly Excellence (PRSE) at Colorado State University. The IDR…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
SUZETTE Alise PRIOLA · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $889,806 — Transmissible spongiform encephalopathies (TSEs or prion diseases) are a group of rare neurodegenerative diseases which include sporadic Creutzfeldt-Jakob disease (sCJD) in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) in mule deer and elk. Prion…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
BYRON CAUGHEY · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $1,371,020 — 1) Real-time quaking-induced conversion (RT-QuIC) assays detect prion-seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs. The assay has shown high diagnostic accuracy in patients with prion disorders. Recently, advances in these tests have l…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
RONALD B CORLEY · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $1,916,668 — Administrative Core Summary The NEIDL Administrative Core provides the leadership, organizational structure, and direction of an established management plan that sustains the resources and infrastructure of the NEIDL at the highest level. This enables us to meet our mandate as a member of NIAID’s na…