Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Daniel Levy · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $2,703,246 — As part of the Population Sciences Branch (PSB), the Levy Lab conducts genetic and multidimensional omics research focused on cardiovascular disease (CVD) and its risk factors. Two important areas of the Levy Lab's intramural research are: 1) blood pressure (BP) genetics 2) multidimensional omics o…
Joseph Frank · CLINICAL CENTER · 2022 — A CNN architecture was used to create a deep learning-based segmentation model of the liver seen on CT scans of a nonhuman primate (NHP). The CNN architecture was optimized by implementing a feature pyramid network (FPN). This FPN model was then utilized to generalize liver segmentation to other org…
THOMAS E DEVER · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2022 · $2,032,638 — We study the mechanism and regulation of protein synthesis in eukaryotic cells. Of special interest are the regulation of protein synthesis by GTP-binding (G) proteins and protein phosphorylation. In addition, we are studying unusual post-translational modifications of the factors that assist the ri…
Jessica Manning · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $38,687 — DESCRIPTIVE EPIDEMIOLOGY TO INFORM THE CAMBODIAN PUBLIC HEALTH RESPONSE TO COVID19 PANDEMIC. NIAID Cambodia ICER quickly repurposed an existing metagenomics pipeline, originally set up for vector-borne diseases, to genetically characterize index cases of COVID-19 in January 2020. At this early pre…
Michael Grigg · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $179,976 — Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the etiologic agent of COVID-19, emerged in 2019 as a public health emergency and global pandemic. SARS-CoV-2 is a linear, non-segmented, capped, polyadenylated positive-sense, single stranded RNA virus related to SARS-CoV and MERS-CoV, t…
Jason Gall · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $4,391,926 — Coronavirus vaccines and protein reagents will be developed at the VPP. The vaccines may be manufactured through the VCMP for human clinical trials in compliance with current Good Manufacturing Practices (cGMP) and released for use in human clinical trials in healthy human volunteers. These vaccines…
Manas Ray · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $1,517,648 — The NIEHS knock out mouse core (KOMC) is a service orientated facility, which aims at helping investigators at the NIEHS to develop animal models to further their research and fulfilling the mission statement of NIEHS. The KOMC aids investigators in generating transgenic mouse models specific for th…
Adrian McDermott · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $2,457,478 — In March 2020 the VIP began working in collaboration with VRC laboratories on the trial readouts for the Phase 1 DMID 20-0003 trial. Later that year the VIP was working within the Operation Warp Speed (OWS) (now called Countermeasures Accelerations Group) testing USG identified CoVID-19 vaccines. T…
Xin Wei Wang · DIVISION OF BASIC SCIENCES - NCI · 2022 · $254,693 — In collaboration with Luigi Notarangelo, MD, Irini Sereti, MD and Andrea Lisco, MD, PhD of NIAID, we are working to determine the landscape of viral exposure signature as the humoral immunological responses to the history of viral infection in COVID-19-positive patients using the VirS…
Kaitlyn Sadtler · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2022 · $641,377 — Analysis of SARS-CoV-2 Seroprevalence in the US Population and Rare Disease Patients Previously we established a range of antibody tests to evaluate SARS-CoV-2 seroprevalence (JoCI, 2021, Nat Comms 2021, JID 2021) in the US population (STM 2021, medRxiv) and abroad including Africa and Southeast As…
Wah Chiu · STANFORD UNIVERSITY · 2022 · $3,880,029 — ABSTRACT An integrated Structural Biology Core will be established to enable the Research Projects’ scientists employing state-of-the-art tools for structural determinations from RNA, protein to virus and virus infected cells. This Core is made up of three Subcores including protein production, x-ra…
Matthew Memoli · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $548,539 — Mosquito-borne diseases continue to cause significant morbidity and mortality worldwide despite on-going control efforts. In 2015, there were >200 million cases of malaria worldwide, causing nearly half a million deaths, with most of the deaths occurring among children under the age of 5 years. Mo…
Helen Chun-Hui Su · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $470,537 — These studies have been organized as part of a broader effort among multiple principal investigators in the Intramural Research Programs of NIAID, NIDCR, NCI, and NIAMS, as well as a research collaborative agreement with investigators at the American Genome Center/Uniformed Services University of th…
Stephen Leppla · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $51,366 — The monoclonal S9.6 antibody has the unique property of recognizing DNA/RNA hybrids in a sequence-independent manner. Previously, we popularized this antibody and made it available to hundreds of researchers. We worked with NIH tech transfer staff to license this antibody to several leading reagent …
JAMES C MULLIKIN · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · 2022 · $10,295,725 — Over the last year, NISC operated the following suite of production sequencing machines: 1 PacBio Sequel 2, 1 NovaSeq 6000, 1 Oxford Nanopore GridION, 1 Oxford Nanopore PromethION, and 3 MiSeqs. Using these platforms, we have generated over 3,259 billion reads in the past year. Though we remain cons…
Ighovwerha Ofotokun · EMORY UNIVERSITY · 2022 · $1,186,474 — PROJECT SUMMARY/ABSTRACT The Clinical Research Core (CRC) (Core D) provides services to support researchers conducting human subjects research studies investigating the pathogenesis of HIV disease, treatment and prevention of HIV, strategies to eliminate HIV from those who are infected, and the redu…
Daniel E Voth · UNIV OF ARKANSAS FOR MED SCIS · 2022 · $228,000 — PROJECT SUMMARY/ABSTRACT A primary means of research support for investigators in the Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR) in Phase III will be the NIGMS-funded Pilot Grant Program (PGP), supplemented with institutional funds ($100,000 per year for each year) t…
Olivier Elemento · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2022 · $147,304 — Data Management Core Principal Investigator: Olivier Elemento, PhD. Co-I: Zhengming Chen, PhD Abstract This Core will provide bioinformatics expertise and support with data integration and analyses. The Core will serve three main goals. First, it will provide central data storage and data management…
John Damon Chodera · SLOAN-KETTERING INST CAN RESEARCH · 2022 · $7,107,143 — PROJECT SUMMARY / ABSTRACT - Administrative Core The AI-driven Structure-enabled Antiviral Platform (ASAP) AViDD Center is organized as a distributed antiviral discovery effort that will produce---in addition to three Investigational New Drug (IND) applications---a robust pipeline of open science da…
Reuben S Harris · UNIVERSITY OF MINNESOTA · 2022 · $7,505,644 — Core A – Administration ABSTRACT The primary goals of Core A – Administration are to provide leadership, logistical support, and coordinated communication for all members and collaborators of the Midwest AViDD Center in order to expedite the successful completion of all specific aims. The PI of Cor…