Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
YE ZHENG · FRED HUTCHINSON CANCER CENTER · 2024 · $12,355 — PROJECT SUMMARY/ABSTRACT Advances in single-cell technologies have enabled three-dimensional (3D) genome structure profiling and simultaneous capture of the transcriptome and epigenome within a cell. Quantitative tools are, however, still unable to fully leverage the unprecedented resolution of sing…
JASON T BLACKARD · UNIVERSITY OF CINCINNATI · 2024 · $697,172 — Abstract HIV/AIDS continues to be a major global health issue, and chronic liver disease has become a major cause of HIV-mortality. Several contributing factors are recognized including hepatotoxicity of anti-HIV drugs, coinfection of hepatitis viruses and widespread alcohol use. The likelihood of c…
Brandon Blake Holmes · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $210,306 — Alzheimer's disease (AD) is an intractable neurodegenerative disorder that devastates approximately 6.2 million Americans nationwide. Emerging evidence now establishes a central role for microglia in AD pathogenesis and reveals that transcriptional and epigenetic level changes in these cells tightly…
Timothy Jensen Henrich · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $191,388 — ABSTRACT/SUMMARY The primary goals of this K24 award are to identify and cultivate diverse, highly motivated, young investigators with a propensity for independent thinking, and increase their involvement in collaborative, patient-oriented HIV pathogenesis and cure research. Specifically, junior inv…
Alexander Sandhu · STANFORD UNIVERSITY · 2024 · $137,305 — PROJECT SUMMARY/ABSTRACT Heart failure causes over 80,000 deaths and $30 billion in spending annually, yet therapies that improve survival and reduce morbidity are underutilized. Insufficient healthcare quality and high costs sparked the development of value-based payment programs, such as Medicare’…
Stephanie Crowley McWilliam · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $489,568 — PROJECT SUMMARY A majority of older adolescents in the U.S. are chronically sleep deprived, getting 1- 2 h less sleep than recommended. The circadian (~24-h) system shifts later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents. Early school st…
KORNELIA POLYAK · DANA-FARBER CANCER INST · 2024 · $1,007,771 — PROJECT SUMMARY: Breast cancer is the most common cancer and the leading cause of cancer deaths in women world- wide. While targeted and immune therapies have improved patient outcomes, a significant fraction of patients fail to respond to treatment and die of their disease. Most of these therapeuti…
Humam Kadara · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $593,147 — PROJECT SUMMARY A significant fraction of lung adenocarcinomas (LUADs) in lifetime smokers harbor somatic mutations in the KRAS oncogene (KM-LUADs). Due to enhanced screening, KM-LUAD is increasingly being detected at earlier pathological stages, thus posing a growing public health burden that warra…
Trenette Clark Goings · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $377,477 — PROJECT SUMMARY The biracial population is the second-fastest growing demographic group in the US. Biracial adolescents also have higher risks of substance use as well as violent behavior, school problems, and poor physical and mental health than many of their monoracial peers. However, little is k…
STELLA AGUINAGA BIALOUS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $633,384 — ABSTRACT Tobacco use is the leading preventable cause of death and is responsible for a third of cancer deaths in the US. Tobacco-induced diseases and mortality are not equally distributed. Racial, ethnic, gender and sexual orientation minorities, as well as those living below the poverty line and w…
DAVID E MOORMAN · GORDON RESEARCH CONFERENCES · 2024 · $25,000 — SUMMARY/ABSTRACT The prefrontal cortex (PFC) is involved in all aspects of cognition and behavior and has established roles in all forms of mental illness and substance use disorders. The PFC has been studied intensely over the past four decades. Interest in studies of the PFC in animal models has g…
Matthew Blake Greenblatt · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $606,973 — Project Summary Approximately .5% of children are born missing a limb, and 2.1 million in the US alone are living with limb loss. Current management for these patients largely relies on the use of prostheses, however most prosthetic use is marked by significant patient dissatisfaction due to functio…
Kathryn Amy Cross · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $242,055 — PROJECT SUMMARY A promising strategy to improve neuromodulation therapies (e.g. deep brain stimulation) in Parkinson’s Disease (PD) is to develop stimulation paradigms that target specific neural signals. Most previous work has aimed to identify and reduce pathologic signals. An unexplored alternat…
Radhika Subramanian · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $336,000 — ABSTRACT The Hedgehog (Hh) signaling pathway is a major intercellular signaling pathway important for embryonic development and adult tissue homeostasis. Errors in Hh signaling are linked to several newborn birth defects such as skeletal malformations and craniofacial defects, and associated with mu…
DANE B. COOK · WM S. MIDDLETON MEMORIAL VETERANS HOSP · 2024 — Chronic multi-symptom illnesses (CMI) are complex and poorly understood diseases principally characterized by fatigue, pain, and problems with cognitive function. For Veterans, these diseases are collectively referred to as Gulf War Illnesses (GWI) and affect ~250,000 Gulf War Veterans (GVs) (25-35%…
Nathan A Dahl · UNIVERSITY OF COLORADO DENVER · 2024 · $189,896 — PROPOSAL SUMMARY Diffuse intrinsic pontine gliomas (DIPGs) are aggressive brainstem tumors in children with no curative therapies available. DIPGs are canonically driven by recurrent mutations in the histone 3 gene (H3K27M). This substitution imparts broad dysregulation of the histone post-translati…
Karen Reue · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $1,467,135 — Overall SUMMARY The objective of our SCORE on “Sex Differences in Cardiometabolic Health and Disease” is to identify factors that determine sex-specific cardiometabolic disease risk, which may lead to better diagnosis and treatment for both sexes. A unique feature of our program is the investigatio…
Peter Leif Bergsagel · MAYO CLINIC ARIZONA · 2024 · $2,098,348 — PROJECT SUMMARY/ABSTRACT The Mayo Clinic Multiple Myeloma SPORE (SPORE) is a dynamic, productive, translational cancer research program based at all three Mayo Clinic sites (Rochester MN, Jacksonville FL, Phoenix AZ), now with input from the Princess Margaret Cancer Centre in Toronto, Ontario. From …
XIAOMIN FAN · AVANTGEN, INC. · 2024 · $1,398,552 — Abstract Patients diagnosed with myelodysplastic syndrome (MDS) face a challenging treatment landscape, with limited options consisting mainly of blood transfusions and hypomethylating agents. This therapeutic regimen has remained stagnant for the past two decades. Adding to the complexity, a signif…
Jake J. Hays · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $36,536 — PROJECT SUMMARY. The economy and the family—two social institutions that strongly affect health and well-being in the US—have undergone profound change in the last half-century. The economy changed through the stagnation of male wages, declining manufacturing jobs and rising service sector employmen…