Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Teri Wang Odom · NORTHWESTERN UNIVERSITY · 2024 · $303,393 — PROJECT SUMMARY This renewal application builds on our discovery that the shape of nanoparticle-based constructs—what we define as structural valency—plays a key role in preserving the targeting ligand characteristics of nanoconstructs even when coated by a protein corona. Protein corona formation …
Javier Gordon Ogembo · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $840,321 — PROJECT SUMMARY More than 44,000 new cases of Kaposi sarcoma (KS) are reported globally each year, 84% of which occur in Africa. This and other Kaposi sarcoma-associated herpesvirus (KSHV)-induced malignancies predominate in people with acquired or iatrogenic immunodeficiencies. Although KSHV can be…
Leonard B Bacharier · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $1,663,001 — ABSTRACT The overarching goals of this proposal are 1) to maintain retention of children in the INSPIRE birth cohort with emphasis on diversity, and implementation of the ECHO Cohort Protocol with high fidelity, and 2) tackle the major limitation in diagnosis and management of childhood asthma - ad…
Brandon Chen · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $42,094 — PROJECT SUMMARY Colorectal cancers (CRC) are characterized as having a hierarchical organization requiring proliferating and de-differentiated stem cells to maintain tumor growth and progression. Cellular plasticity underlying colorectal cancer is essential for a process which occurs following selec…
Jamila D Michener · CORNELL UNIVERSITY · 2024 · $561,520 — ABSTRACT Racial/ethnic minority populations in the United States face pervasive disparities in health care access, utilization, and outcomes. Access to transportation is an important factor that has the potential to affect access to care. Past work has found that improved transportation has signifi…
DARIO L RINGACH · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $596,259 — Project Summary / Abstract A long-term goal of our research is to understand how cortical neurons become tuned to stimulus features and organized into cortical maps. Our working hypothesis is that the spatial distribution of ON/OFF inputs from the geniculate seeds simple-cell receptive fields, corti…
Jiaoyang Jiang · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $397,900 — Abstract The essential human enzyme O-GlcNAc transferase (OGT) catalyzes a unique type of intracellular protein glycosylation called O-GlcNAcylation. In response to nutrient levels and stress, OGT dynamically regulates a variety of physiological and pathological processes including the “Warburg eff…
Adam Courtney · CONTINUUM EDUCATIONAL TECHNOLOGIES, PBC · 2024 · $1,474,925 — PROJECT SUMMARY Continuum Educational Technologies’ (Continuum) will work with the University of Kansas (KU) on the proposed I-RED program entitled Smart Tools to Accelerate Research Translation by Uplifting Participants for the Central IDeA State Region (STARTUP Central) program to stimulate techno…
Adam Bryant Miller · RESEARCH TRIANGLE INSTITUTE · 2024 · $845,310 — PROJECT SUMMARY/ABSTRACT Despite misconceptions that young children do not experience self-injurious thoughts and behaviors (STBs), data from samples of youth that include children under age 9 suggest rates of suicidal ideation between 11%–19%, non-suicidal self-injury at 6.2%–21%, and suicide attem…
Shoshannah Iylene Eggers · UNIVERSITY OF IOWA · 2024 · $242,325 — PROJECT SUMMARY I am an environmental epidemiologist and microbiome researcher with a primary research interest in the role of the human microbiome between environmental exposures and human health, including neurological outcomes. The goal of this proposal is to obtain training and acquire the skill…
KHANDAN KEYOMARSI · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $430,381 — As a recognized leader in cancer research,1 MD Anderson Cancer Center is uniquely positioned to train and support the career development of the next generation of cancer researchers. We will do so via early intervention programs that foster sustained interest in cancer research in students with limi…
Jana Jarolimova · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $195,569 — PROJECT SUMMARY Curable sexually transmitted infections (STIs) are highly prevalent among adolescents and young adults in sub-Saharan Africa, who are also at the highest risk of acquiring HIV. Untreated STIs, such as gonorrhea, chlamydia, and trichomoniasis, increase HIV acquisition and transmission…
Alexandra Munch · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $47,374 — PROJECT SUMMARY Alzheimer’s disease (AD) is a grave neurodegenerative disorder characterized by unrelenting memory loss and deficits in executive function with no effective treatment. Accumulating evidence from genome wide association studies (GWAS) posit that the brain’s innate immune system plays …
Edda Frauke Spiekerkoetter · STANFORD UNIVERSITY · 2024 · $688,595 — Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease characterized by multiple arteriovenous malformations (AVMs) which are direct connections between arteries and veins, bypassing the capillary bed. Pulmonary AVMs (PAVMs) are the most common visceral AVMs in adult (10-45%) and pediatric…
DON C. ROCKEY · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $161,182 — Abstract – MUSC HARP Program Underrepresented in medicine (UIM) investigators are insufficiently represented among medical school faculty. The reasons for this underrepresentation are complex, and have been attributed to such factors as implicit bias, promotion disparities, lack of role models, and…
Elaine Khoong · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $180,200 — PROJECT SUMMARY This is an application for a Career Development Award for Dr. Elaine Khoong, an Assistant Professor at the University of California San Francisco, whose career goal is to be an embedded health system researcher that applies informatics to conduct interventional implementation resear…
Victoria Diane Powell · VETERANS HEALTH ADMINISTRATION · 2024 — Background: Chronic low back pain (CLBP) and depression are the two most common causes of disability in America. When they occur together, patients have more functional limitations, higher healthcare spending, and treatment is more likely to fail. Ideal treatments would address pain interference wit…
Elisa Biondi · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · 2024 · $215,564 — ABSTRACT Cancer research is often driven by hypotheses that postulate that a specific protein is important for the disease, hypotheses often tested by adding an antibody to that system. The technology to be developed here will create new reagents (AEGISbodies and AEGISCleavers) that not only bind a…
Pawel Kalinski · ROSWELL PARK CANCER INSTITUTE CORP · 2024 · $1,494,670 — The revised P01CA234212 tests novel strategies to promote selective CTL entry into tumor micro- environments (TME) and sensitize “cold” tumors to immunotherapy. Our preclinical and early clinical data demonstrate that the chemokine-modulating (CKM) regimen targeting toll-like receptor-3 (TLR3), type…
Ethan Cerami · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $1,447,287 — PROJECT SUMMARY Genomic sequencing of tumor samples is now a routine component of cancer care, providing unprecedented insight into cancer initiation, progression, and treatment effects. Additionally, novel molecular profiling and imaging techniques are gaining traction, generating ever more data. E…