Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Eric Grodsky · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $25,903,976 — PROJECT SUMMARY/ABSTRACT Education is among the most important determinants of later-life cognitive functioning and biological markers of AD/ADRD risk. However, we know very little about how, why, or for whom education matters for these cognitive outcomes. This makes it difficult to design effective…
Yi Fan · UNIVERSITY OF PENNSYLVANIA · 2024 · $588,825 — Project Summary Ischemic heart disease is the most common cause of death in the western world, largely due to myocardial infarction (MI), the irreversible damage of myocardial tissue induced by the blockage in coronary arteries. After MI, formation of new blood vessels, i.e., neovascularization, is …
Stefan Aigner · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $787,592 — PROJECT SUMMARY Autism spectrum disorder (ASD) is a clinically complex, heterogeneous condition affecting 1 in 44 children in the U.S. The identification of common etiologies across multiple forms of genetic and idiopathic forms of ASD will critically advance diagnostic biomarker discovery and thera…
MICHAEL W QUASNEY · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $154,440 — PROJECT SUMMARY/ABSTRACT – University of Michigan Pediatric Critical Care Medicine incorporates a multidisciplinary approach to address the medical needs of the most fragile population of critically ill and injured children. While current mortality rates at most academic, tertiary care children’s h…
Nina Nishiyama · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $42,574 — 1 PROJECT SUMMARY/ABSTRACT 2 3 Inflammatory bowel diseases (IBDs) such as Crohn’s disease and ulcerative colitis are chronic inflammatory 4 disorders that cause damage to the gastrointestinal tract. There is no cure for IBD. Current therapies treat 5 inflammatory responses but do not target under…
Saurin Kantesaria · UNIVERSITY OF MINNESOTA · 2024 · $42,943 — Abstract Unfortunately, ~20% of kidneys donated for transplant are discarded due to short storage viability (~24-36 h). Cryopreservation decreases storage temperatures below -140oC, enabling storage of kidneys for months to years. To re-warm cryopreserved kidneys without ice formation and cracking, …
Jacob Kahrs · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $39,732 — Project Summary/ Abstract Significance: Urinary tract infections (UTIs) are the most common infection during pregnancy. While these infections are typically minor, they are associated with an increased risk of preterm birth, low birth weight, pyelonephritis and sepsis. Despite this, there is insuffi…
Hao Gong · MAYO CLINIC ROCHESTER · 2024 · $212,507 — PROJECT SUMMARY/ABSTRACT Around 80 million US adults will have arthritis by 2040, which causes a significant societal problem resulting in an annual healthcare cost of > $136.8 billion. These progressive degenerative diseases result in long-term functional disabilities and morbidities leading to act…
Xinyi Jenny He · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $74,080 — Project Summary Neuromodulators control the state of an animal’s brain and thus behavior through the activation of G protein- coupled receptors (GPCRs). Although the role of neuromodulation has been appreciated for decades, the chemical logic of neuromodulation has remained elusive due to inadequate…
Trevor Stanley Tippetts · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $77,284 — Project Summary Metabolism is essential for normal cellular function and dynamically changes to meet organism and tissue needs. Cardiac function and metabolism are closely intertwined. Fatty acid oxidation serves as the primary means to provide energy in normal conditions. In heart failure, cardiom…
Charlotte Helena Rivas · BAYLOR COLLEGE OF MEDICINE · 2024 · $51,974 — ABSTRACT/PROJECT SUMMARY. Triple-negative breast cancer (TNBC) is a heterogenous set of diseases and is considered one of the most aggressive breast cancer subtypes. TNBC lack of well-defined endocrine markers limits the therapeutic options for these patients. This has spurred significant efforts to…
Kurt T Barnhart · UNIVERSITY OF PENNSYLVANIA · 2024 · $680,699 — Project Summary Aspirin is currently recommended during pregnancy to help prevent preeclampsia, and also shows promise for protecting against pregnancy loss. Preeclampsia is a dangerous complication of pregnancy that puts both the pregnant person and their baby at risk of serious morbidity and death…
Moises Arturo Huaman Joo · UNIVERSITY OF CINCINNATI · 2024 · $607,624 — Project Summary Persons living with HIV (PLWH) have a 1.5- to 2-fold increased risk of cardiovascular disease (CVD) compared to the general population. Immune activation, particularly driven by coinfections, is considered an important contributor in that enhanced risk. However, whether Mycobacterium…
Ingunn Margarete Stromnes · UNIVERSITY OF MINNESOTA · 2024 · $336,835 — PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy with a 5-year overall survival of <10%. Lethality is due to late diagnosis, early metastasis and therapeutic resistance. A hallmark characteristic of PDA is the robust fibroinflammatory and suppressive tumor microen…
Prateek Sharma · UNIVERSITY OF PENNSYLVANIA · 2024 · $36,662 — PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer mortality and is significantly affected by multifactorial influences including host genetic and epigenetic factors, diet, and microbial composition. One of the most intriguing interventions for mitigating cancer risk and p…
Kacie McCarty · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $41,614 — Project Summary Microsporidia are an early diverging group of fungal pathogens that infect a wide variety of hosts ranging from insects to humans. Encephalitozoon intestinalis is one of the main human-infecting species of microsporidia which causes diarrhea and wasting syndrome in patients and can b…
Jacob Roshgadol · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $41,972 — Project Summary This proposed research aims to provide a roadmap for studying dopamine dynamics using a novel optical tool, dLight, deepening our understanding of dopamine biology. Altered dopamine signaling is central to many neurological and neuropsychiatric disorders, yet we lack effective treatm…
Meagan Branch · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $47,374 — Project Summary The epidermis is a vital tissue that protects our bodies against infection and environmental insults. Upon wounding, epidermal basal cells undergo a transient transcriptional switch to increase proliferation and migrate into the wounded area to re-epithelize the epidermis. Regulation…
Chikage Noishiki · STANFORD UNIVERSITY · 2024 · $86,488 — PROJECT SUMMARY Varicose veins (VV), which affects approximately 23% of adults in the USA are non-lethal however, it negatively impacts the quality of life in many patients due to its debilitating symptoms. With limited methods for prevention and early treatments for VV, there is an unmet need to un…
Sarah A Dooley · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $44,698 — Project Summary/Abstract Inflammatory bowel disease (IBD), comprising Crohn's Disease and Ulcerative Colitis, is a chronic condition characterized by gastrointestinal inflammation. Among the IBD subtypes, Crohn’s disease is the most common, affecting 1.6 million individuals in the United States toda…