Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Juergen A Richt · KANSAS STATE UNIVERSITY · 2022 · $2,263,387 — Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Scien…
SUZETTE Alise PRIOLA · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $1,164,826 — Transmissible spongiform encephalopathies (TSEs or prion diseases) are a group of rare neurodegenerative diseases which include sporadic Creutzfeldt-Jakob disease (sCJD) in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) in mule deer and elk. Prion…
JILL E HUTCHCROFT · PURDUE UNIVERSITY · 2022 · $82,914 — Flow Cytometry Shared Resource (FC-SR) Project Summary The Purdue Flow Cytometry Shared Resource (FC-SR) provides advanced cell and particle analysis, cell sorting and single cell genomic capabilities to members of the Purdue University Center for Cancer Research (PCCR). The FC-SR has made major i…
Thomas William Geisbert · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2022 · $802,301 — Abstract Among viruses that cause disease in humans the henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), stand out for their impressive lethality. These viruses are among the most deadly human pathogens known to man with case fatality rates averaging about 75% for NiV. Significantly, there i…
RONALD B CORLEY · BOSTON UNIVERSITY MEDICAL CAMPUS · 2022 · $658,414 — Administrative Core Summary The NEIDL Administrative Core provides the leadership, organizational structure, and direction of an established management plan that sustains the resources and infrastructure of the NEIDL at the highest level. This enables us to meet our mandate as a member of NIAID’s na…
Jay Kenneth Fisher · REDBUD LABS, INC. · 2022 · $998,995 — ABSTRACT We propose to develop a point-of-need system for differential molecular identification of filoviruses from syndromically similar infections. Our goal is to enable rapid, sensitive, and specific identification of quarantinable infections to reduce nosocomial risk and improve outbreak respons…
KENNETH M KAUFMAN · CINCINNATI VA MEDICAL CENTER RESEARCH · 2022 — The new Covid-19 virus is deadly for 0.2% to 4% of people infected, with older men the most severely afflicted with this scourge, being mortal to ~15% of those infected over 80 years, making the US Veteran population especially vulnerable. It is critically important to understand the mechanisms of t…
Jae U Jung · CLEVELAND CLINIC LERNER COM-CWRU · 2022 · $604,163 — Project Summary/Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) listed in the World Health Organization 9 most dangerous pathogens is an emerging Phlebovirus in the Phenuiviridae family. Due to the lack of therapy and vaccine against SFTSV infection, there is a pressing need to u…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $7,043,167 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2022 · $1,677,497 — The mission of the CCR LGI Flow Cytometry Core in Building 37 (FC37) is to offer up-to-date instrumentation and technical expertise to CCR investigators to assist cancer research. The core provides full-scale, state-of-the-art flow cytometry services including analytical sample acquis…
Daniel S Chertow · CLINICAL CENTER · 2022 — Project 1: We previously developed a NHP ICU model in healthy (uninfected) NHPs. We have extended this model to included supportive care of animals infected with E.coli or K. pneumoniae. Among K. pneumoniae infected animals, we have completed initial bacterial dose-response studies and are now proc…
Parizad Torabi-Parizi · CLINICAL CENTER · 2022 — Coronavirus disease 19 (COVID-19) is a rapidly growing health threat in the United States with a fatality rate ten times greater than with seasonal influenza. The virus is highly transmissible and has rapidly infected large numbers of people in China, in several European countries, and now in the US…
Alexander Bukreyev · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $361,188 — ADMINISTRATIVE CORE (Core A): PROJECT SUMMARY/ABSTRACT The Administrative Core is responsible for the strategic planning, overall management, and coordination of the Program Project (P01) “Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus”. It provides governance, financial ove…
Kevin Michael Tuohey · BOSTON UNIVERSITY MEDICAL CAMPUS · 2022 · $1,900,368 — Core 3: Environmental Health and Biosafety Regulations and Requirements Abstract The Environmental Health and Biosafety Regulations and Requirements (EHBRR) Core includes three components: Environmental Health and Safety, Emergency Management, and Occupational Medicine. The Core is integrated with c…
ANKITA GARG · UNIVERSITY OF GEORGIA · 2021 · $547,000 — PROJECT SUMMARY/ABSTRACT Investigators at UGA have established national and international recognition for their research on high- containment pathogens of global importance. UGA investigators are working towards understanding pathogenesis and developing newer vaccines, therapeutics and diagnostics t…
KENNETH M KAUFMAN · CINCINNATI VA MEDICAL CENTER RESEARCH · 2021 — The new Covid-19 virus is deadly for 0.2% to 4% of people infected, with older men the most severely afflicted with this scourge, being mortal to ~15% of those infected over 80 years, making the US Veteran population especially vulnerable. It is critically important to understand the mechanisms of t…
Junki Maruyama · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $113,977 — PROJECT SUMMARY/ABSTRACT This career development award will help fill in the knowledge and skills in basic virological research of Risk Group 4 agents, which need to be handled in the highest containment laboratory (BSL-4). This is essential for the goal to become an independent researcher as an exp…
David Alland · RBHS-NEW JERSEY MEDICAL SCHOOL · 2021 · $3,328,439 — PROTECT ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) research for academic and commercial entities within Rutgers University, the Northeast United States, and beyond. Heavily used for high-threat pathoge…
Jakob Trimpert · KANSAS STATE UNIVERSITY · 2021 · $3,430,993 — SUMMARY: Kansas State University (KSU) is well-positioned to become the preeminent institution to advance the discovery and development of biosecurity strategies for emerging and zoonotic infectious diseases. With KSU’s Biosecurity Research Institute (BSL-3), USDA’s Arthropod-Borne Animal Disease Re…
Christopher F Basler · GEORGIA STATE UNIVERSITY · 2021 · $180,913 — Project Summary Filoviruses, which include the ebolaviruses and marburgviruses, are non-segmented, negative-sense RNA viruses (NNSVs) that cause severe human disease. These viruses are of concern as emerging pathogens and as potential bioterrorism threats. Their importance and public health impact a…