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Principal Investigator: JOEL H KRAMER
Organization: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Fiscal Year: 2024
Award: $1,050,008
Funding agency: National Institute of Neurological Disorders and Stroke
PROJECT SUMMARY/ABSTRACT
Small vessel cerebrovascular disease is common in the elderly, and is a well-known contributor to cognitive
decline. A major gap in the field, however, is the ongoing need for reliable and reproducible biologic markers of
vascular disease suitable for early detection, disease monitoring, and measuring treatment efficacy. The
overarching goal of this proposal is to clinically validate novel neuroimaging and fluid-based biomarkers of
cerebrovascular disease selected by the NINDs and developed during the first five years of the MarkVCID
consortium. We propose to longitudinally follow a cohort of 200 diverse, older subjects who present with a
range of cerebrovascular burden and cognitive complaints and functional decline. Our aims are to validate the
MarkVCID biomarkers and address possible interactions between these biomarkers and Alzheimer’s disease
pathophysiology. Accomplishing these goals will improve early detection, diagnosis, and prognosis of small
vessel cerebrovascular disease in older subjects and provide better targets and outcome metrics for clinical
trials.
Terms: <AD dementia><Active Follow-up><Address><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Behavioral><Biologic Models><Biological><Biological Markers><Biological Models><Blood Plasma><Blood Vessels><Brain Vascular><Brain Vascular Disorders><COVID-19><CV-19><California><Cell Communication and Signaling><Cell Signaling><Censuses><Cerebrovascular Disease><Cerebrovascular Disorders><Cerebrovascular system><Clinical><Clinical Sciences><Clinical Trials><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Coronavirus Infectious Disease 2019><Data><Dementia><Development><Diagnosis><Diffusion><Disease><Disease Pathway><Disorder><Disturbance in cognition><Dysfunction><Early Diagnosis><Early identification><Elderly><Endothelium><Endowment><Enrollment><Foundations><Functional disorder><Goals><Head><Image><Impaired cognition><Individual><Infrastructure><Injury><Intracellular Communication and Signaling><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Ischemia><Laboratories><Lead><Leadership><Liquid substance><Longitudinal Studies><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Model System><Modeling><Molecular><Monitor><Multi-center clinical study><Multi-site clinical study><Multicenter clinical study><Multisite clinical study><NINDS><NMR Imaging><NMR Tomography><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Neurology><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><Outcome><Pathology><Pathway interactions><Patients><Pb element><Persons><Phase><Phenotype><Physiopathology><Plasma><Plasma Serum><Population Heterogeneity><Primary Senile Degenerative Dementia><Probabilistic Models><Probability Models><Productivity><Prognosis><Protocol><Protocols documentation><Psychometrics><Public Health><Reproducibility><Research><Reticuloendothelial System, Serum, Plasma><Sampling><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Site><Specific qualifier value><Specified><Statistical Models><Techniques><Testing><Treatment Efficacy><Universities><Validation><Vascular Diseases><Vascular Disorder><Work><Zeugmatography><active followup><advanced age><ages><alzheimer risk><bio-markers><biologic><biologic marker><biological signal transduction><biomarker><biomarker development><blood vessel disorder><blood vessels in the brain><brain blood vessels><brain vascular disease><brain vascular dysfunction><brain vasculature><cardiac disease induced cognitive impairment><cerebral blood vessel><cerebral vascular><cerebral vascular disease><cerebral vascular dysfunction><cerebral vasculature><cerebro-vascular><cerebrovascular><cerebrovascular dysfunction><cerebrovascular vessels><cerebrovasculature><clinical phenotype><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cohort><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><decline in function><decline in functional status><developmental><diffused><diffuses><diffusing><diffusions><diverse populations><early detection><enroll><exosome><experience><fluid><follow up><follow-up><followed up><followup><functional decline><functional status decline><geriatric><heavy metal Pb><heavy metal lead><heterogeneous population><image processing><imaging><improved><injuries><innovate><innovation><innovative><intervention efficacy><intracranial vascular dysfunction><liquid><long-term study><longitudinal outcome studies><longterm study><member><mild cognitive disorder><mild cognitive impairment><neural imaging><neuro-imaging><neuroimaging><neurological imaging><neuropsychologic><novel><outcome prediction><pathophysiology><pathway><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><population diversity><precision medicine><precision-based medicine><primary degenerative dementia><professor><recruit><senile dementia of the Alzheimer type><senior citizen><statistical linear mixed models><statistical linear models><substantia alba><therapeutic efficacy><therapy efficacy><tool><validation studies><validations><vascular><vascular cognitive impairment and dementia><vascular contributions to cognition/dementia><vascular contributions to cognitive impairment and dementia><vascular dysfunction><vasculopathy><white matter>