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Principal Investigator: Pamina Mae Gorbach
Organization: UNIVERSITY OF CALIFORNIA LOS ANGELES
Fiscal Year: 2020
Award: $326,106
Funding agency: National Institute on Drug Abuse
ABSTRACT
In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and
Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047
and linked Program Announcement PA-18-591) funding opportunity, the Collaborating Consortium of Cohorts
Producing NIDA Opportunities (C3PNO; U24DA044554) proposes a project to assess the impact of COVID-19
on the participating cohorts' population of substance-using people living with HIV (PLWH) and those at high-risk
for HIV infection. Our innovative study proposes to collect data from a subset of participants from each of seven
participating C3PNO cohorts at two time points – in the height of the COVID-19 pandemic and during its
mitigation and control – in order to assess the impact of the COVID-19 epidemic on substance use for PLWH
and those at high risk for HIV. We will use our current infrastructure and C3PNO validated harmonization
strategies to compile new and existing data across the cohorts in order to: assess changes in social and
individual determinants of health during the course of the COVID-19 pandemic, to estimate differences in
substance-using behaviors of those who were confirmed/probable cases of COVID-19 (based on self-report or
medical record) and those who were not a confirmed/probable case, and to assess how PLWH and people who
are at high risk for HIV in C3PNO have different experiences in and responses to the COVID-19 epidemic as
compared to other HIV studies and cohorts that have less substance use. The C3PNO Coordinating Center at
UCLA and Frontier Science will facilitate the design and implementation of a survey to collect data from a subset
of participants from each of seven participating C3PNO cohorts (ALIVE, HYM, JHHCC, MASH, mSTUDY,
RADAR, and V-DUS). Participating cohorts will issue the survey to participants and transfer the resulting data
to the coordinating center. If funded, this administrative supplement would allow a rapid and coordinated
collection of linked COVID-19, HIV, and substance use data related to an ongoing public health emergency
affecting the highly vulnerable substance-using populations followed by the cohorts. COVID-19 data
harmonization with other HIV cohorts will further aide our collective effort to understand the impact of COVID-19
on HIV impacted communities. Finally, C3PNO's effort to assess changes in social and individual determinants
of health during the course of the COVID-19 pandemic as well as estimate differences in substance-using
behaviors and the impact on PLWH or at high risk for HIV is both novel and critical in this time of unprecedented
social upheaval and instability.
Terms: <2019 novel coronavirus><2019-nCoV><AIDS Virus><AIDS prevention><AOD use><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><Administrative Supplement><Adolescent Medicine Trials Network><Adolescent Trials Network><Affect><Alcohol or Other Drugs use><Anti-HIV Positivity><Anxiety><Appointment><Area><Baltimore><Behavior><COVID-19><COVID-19 epidemic><COVID-19 pandemic><COVID19><COVID19 epidemic><COVID19 pandemic><Cannabis><Caring><Chicago><Cities><Cohort Studies><Collection><Communities><Concurrent Studies><Continuity of Care><Continuity of Patient Care><Continuum of Care><Counseling><Crystal Meth><Data><Deoxyephedrine><Desoxyephedrine><Drug usage><Drugs><Family><Food><Food or Food Product><Frequencies><Funding><Funding Opportunities><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Prevention><HIV Seroconversion><HIV Seronegativities><HIV Seronegativity><HIV Seropositivity><HIV antibody positive><HIV negative><HIV prevention trials network><HIV/AIDS prevention><HTLV-III Infections><HTLV-III Seroconversion><HTLV-III Seronegativities><HTLV-III Seronegativity><HTLV-III Seropositivity><HTLV-III-LAV Infections><Health><Height><Home><Home environment><Housing><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Individual><Infrastructure><Injections><Interruption><LAV-HTLV-III><Link><Los Angeles><Lymphadenopathy-Associated Virus><Measures><Medical Records><Medication><Mental Health><Mental Hygiene><Methamphetamine><Methylamphetamine><N-Methylamphetamine><NIDA><NIH Program Announcements><National Institute of Drug Abuse><National Institute on Drug Abuse><Neural Development><North America><Opiates><Opioid><Participant><Patient Self-Report><Pharmaceutic Preparations><Pharmaceutical Preparations><Population><Population Group><PrEP><Prevalence><Prevention><Program Announcement><Psychological Health><Research><Risk Factors><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Science><Self-Report><Severe acute respiratory syndrome coronavirus 2><Smoking><Social isolation><Specific qualifier value><Specified><Substance Use Disorder><Survey Instrument><Surveys><Time><Tobacco><Virus-HIV><Vulnerable Populations><Wuhan coronavirus><YMSM><addiction><addictive disorder><anti-retroviral therapy><anti-retroviral treatment><antiretroviral therapy><antiretroviral treatment><base><cannabis vaping><cohort><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 epidemic><coronavirus disease 2019 pandemic><data harmonization><design><designing><drug use><drug/agent><experience><food insecurity><frontier><harmonized data><high risk><innovate><innovation><innovative><interest><intimate partner violence><licit opioid><marijuana vaping><neurodevelopment><novel><opiate medication><opiate use disorder><opioid medication><opioid use disorder><pre-exposure prophylaxis><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><public health emergency><response><social><stimulant use><substance use><substance using><using substances><vaping><vulnerable group><young MSM><young men who have sex with men>