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Principal Investigator: Leslie I. Katzel
Organization: UNIVERSITY OF MARYLAND BALTIMORE
Fiscal Year: 2024
Award: $385,773
Funding agency: National Institute on Aging
7. Project Summary: Overall
The theme of the UM-OAIC is enablement defined as the restoration of function in those with impairments and
the prevention or delay of further progression in those who are already disabled. The overarching mission of
the UM-OAIC is to develop, implement, and evaluate rehabilitative strategies that are designed to improve and
restore mobility and functional independence in older persons with disabling conditions. This will be
accomplished by 1) advancing our understanding of the mechanisms by which exercise and activity-based and
multi-modal rehabilitation interventions directed at specific impairments affect multiple body systems; 2)
developing and testing interventions to restore function and minimize disability following acute disabling events
and to prevent declines related to serious chronic diseases; and 3) training the next generation of investigators
who will further the understanding of the aging process and develop interventions that help promote health and
independence in older adults with disabling medical conditions.
The functional impairments and disabilities that occur in older people emanate from acute events, such as
stroke, heart attack, and hip fracture, or reflect the progression of chronic diseases. This pathway of how
disease leads to disability, i.e., disablement, has been discussed extensively. The UM-OAIC’s mission builds
knowledge of disablement and focuses on the restoration of function in those with impairments and to prevent
or delay further progression in those already disabled, i.e. enablement.
The aims of the UM-OAIC are to: 1) Conduct research that examines the mechanisms underlying the
functional impairments associated with acute disabling events (e.g., stroke, hip fracture) and prevalent chronic
diseases (e.g., heart failure, cancer) in older people. 2) Design novel, exercise and activity-based and
rehabilitation interventions that produce clinically relevant outcomes and study the mechanisms underlying
them. 3) Translate interventions developed in UM-OAIC clinical laboratories and elsewhere for implementation
and rigorous evaluation in home and community settings. 4) Support pilot and exploratory studies, UM-OAIC
Scholar research, development projects, and externally funded projects that are consistent with the UM-OAIC
theme. 5) Support the development of junior faculty and Scholars from multiple disciplines as they pursue
careers as independent, academic scientists and leaders with expertise in the study of older persons with
disabling diseases through mentor-based, didactic and experiential training in bench-to-bedside-to-community
translational research.
Terms: <AD related dementia><ADRD><Academy><Acute><Adult-Onset Diabetes Mellitus><Aerobic><Affect><Aging><Alzheimer's and related dementias><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><American><Animal Model><Animal Models and Related Studies><Apoplexy><Area><Biometrics><Biometry><Biostatistics><Body System><Brain Trauma><Brain Vascular Accident><CNS plasticity><COVID-19 infection><COVID-19 virus infection><COVID19 infection><Cancers><Cardiac infarction><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Chronic Disease><Chronic Illness><Clinic><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Communities><Death><Degenerative Arthritis><Degenerative polyarthritis><Development><Disablement><Disabling><Disabling condition><Disabling health condition><Discipline><Disease Pathway><Disturbance in cognition><Engineering><Enrollment><Environment><Evaluation><Event><Exercise><Faculty><Fatigue><Functional impairment><Funding><Future><Geriatrics><Health Promotion><Heart failure><Hip Fractures><Home><Impaired cognition><Impairment><Incidence><Informatics><Institutionalization><Intervention><Intervention Strategies><Investigators><Ketosis-Resistant Diabetes Mellitus><Knowledge><Laboratories><Lack of Energy><Leadership><Life Expectancy><Maintenance><Malignant Neoplasms><Malignant Tumor><Maturity-Onset Diabetes Mellitus><Medical><Medical Rehabilitation><Mentors><Mission><Myocardial Infarct><Myocardial Infarction><NIDDM><Neuronal Plasticity><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Older Population><Organ System><Osteoarthritis><Osteoarthrosis><Outcome><Paralysis Agitans><Parkinson><Parkinson Disease><Physiologic><Physiological><Physiology><Prevention><Primary Parkinsonism><Process><Rehabilitation><Rehabilitation therapy><Research><Research Personnel><Research Resources><Research Training><Researchers><Resources><Risk><Robotics><SARS-CoV-2 infection><SARS-CoV2 infection><Salutogenesis><Scientist><Services><Severe acute respiratory syndrome coronavirus 2 infection><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stroke><T2 DM><T2D><T2DM><Technology><Testing><Training><Translating><Translational Research><Translational Science><Traumatic Brain Injury><Treatment Efficacy><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Underrepresented Ethnic Minority><Underrepresented Minority><Vascular Diseases><Vascular Disorder><Work><adiposity><adult onset diabetes><aged animal><aged animals><aging process><animal old age><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><blood vessel disorder><brain attack><cardiac failure><cardiac infarct><career><central nervous system plasticity><cerebral vascular accident><cerebrovascular accident><chronic disorder><clinical center><clinical relevance><clinically relevant><cognitive dysfunction><cognitive loss><community advisory board><community advisory committee><community advisory panel><community setting><coronary attack><coronary infarct><coronary infarction><coronavirus disease 2019 infection><corpulence><degenerative joint disease><design><designing><developmental><disability><disabled><disabling disease><disease associated disability><disease-induced disability><disease-related disability><education research><efficacy testing><elderly animal><enroll><frailty><functional disability><functional improvement><functional independence><functional restoration><geriatric medicine><heart attack><heart infarct><heart infarction><homes><hypertrophic arthritis><improve function><improved><improved functional outcomes><industrial partnership><industry partner><industry partnership><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><innovate><innovation><innovative><intervention efficacy><interventional strategy><ketosis resistant diabetes><malignancy><maturity onset diabetes><model of animal><multi-modality><multimodality><neoplasm/cancer><neural plasticity><neuroplastic><neuroplasticity><new approaches><new technology><next generation><novel><novel approaches><novel strategies><novel strategy><novel technologies><old animals><older adult><older adulthood><older groups><older individuals><older person><operation><operations><osteoarthritic><physical impairment><pre-clinical><preclinical><prevent><preventing><programs><promoting health><public health priorities><rehab research><rehab technology><rehab therapy><rehabilitation research><rehabilitation science><rehabilitation technology><rehabilitative><rehabilitative therapy><restoration><restore function><restore functionality><restore lost function><sarcopenia><sarcopenic><stroked><strokes><therapeutic efficacy><therapy efficacy><translation research><translational investigation><translational pipeline><translational spectrum><traumatic brain damage><type 2 DM><type II DM><type two diabetes><under-representation of minorities><under-represented minority><underrepresentation of minorities><vascular dysfunction><vasculopathy>