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Principal Investigator: Wendy M Kohrt
Organization: UNIVERSITY OF COLORADO DENVER
Fiscal Year: 2024
Award: $1,100,000
Funding agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases
MoTrPAC Project Summary
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will discover and characterize the
range of potential molecular transducers that underlie the health benefits of exercise in humans. MoTrPAC
was launched in 2016 with six adult Clinical Centers and a pediatric Clinical Center that have collaborated
to generate extensive Manuals of Operations to guide research protocols involving all aspects of clinical
operations (Phase I). Phase II began in the fall of 2019 with all Clinical Centers demonstrating excellent
progress toward initial recruitment goals and implementation of the protocol. The initial goal set forth by
the Consortium was to recruit 270 children (10-17 years of age) and 1,980 sedentary adults (aged 18+
years of age) who are randomized to endurance exercise training (170 youth, 840 adults), resistance
exercise training (840 adults), or no-exercise control (50 youth, 300 adults) interventions. Additional groups
of highly active endurance trained (50 youth, 150 adults) or resistance trained (150 adults) individuals
serve as comparator groups and do not undergo the MoTrPAC exercise interventions. The recruitment
and enrollment approaches are sex balanced, with participants across a wide age range (10-17, 18-39,
40-59, and 60+ age groups) and of different races and ethnicity. Due to the COVID-19 pandemic, some
MoTrPAC activities were suspended for more than a year, beginning in March 2020, with continued
constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic,
recruitment activities at the adult and pediatric Clinical Centers have accelerated to a rate that is projected
to successfully achieve the target enrollment numbers by the end of the new award period. This led the
NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to
complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized
controlled trials of sedentary adults and children and observational studies of highly active adults and
children. This will enrich the participant cohorts that are critical to understand the heterogeneity of exercise
adaptations across age, gender, and minority groups. This extension will enable MoTrPAC to complete
the intended goals as originally envisioned and will provide a more complete public database of the health
benefits of exercise and provide insight into how physical activity mitigates disease.
Terms: <0-11 years old><17 year old><17 years of age><18 year old><18 years of age><21+ years old><Acceleration><Active Follow-up><Acute><Adipose tissue><Adult><Adult Human><Age><Ancillary Study><Animals><Attention><Award><Bio-Informatics><Bioinformatics><Biological Function><Biological Process><Blood><Blood Reticuloendothelial System><Body Tissues><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><California><Categories><Charge><Chemicals><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Clinical Protocols><Clinical Research><Clinical Study><Clinical Trials Data Monitoring Committees><Collaborations><Collection><Colorado><Communication><Communities><Coronavirus Infectious Disease 2019><Data><Data Monitoring Committees><Data and Safety Monitoring Boards><Development><Disease><Disease Outcome><Disorder><Enrollment><Ensure><Ethnic Origin><Ethnicity><Exercise><Fatty Tissue><Frequencies><Funding><Gender><Goals><Health><Health Benefit><Heterogeneity><Human><IRB><IRBs><Individual><Individuals from minority><Individuals of minority><Institutional Review Boards><Intervention><Intervention Strategies><Investigators><Manuals><Manuscripts><Maps><Measurement><Minority Groups><Minority People><Minority Population><Minority individual><Modern Man><Molecular><Multi-center clinical study><Multi-site clinical study><Multicenter clinical study><Multisite clinical study><Muscle><Muscle Tissue><NIH><National Institutes of Health><Observation research><Observation study><Observational Study><Observational research><Participant><Pathway interactions><Pediatric cohort><Phase><Phenotype><Physical activity><Physiologic><Physiological><Procedures><Protocol><Protocols documentation><Public Health><Race><Races><Randomized><Randomized, Controlled Trials><Recruitment Activity><Research><Research Personnel><Research Resources><Researchers><Resources><Rest><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Safety Monitoring Boards><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Suspension substance><Suspensions><Testing><Time><Tissues><Training><Transducers><United States National Institutes of Health><Universities><Visit><Woman><Youth><Youth 10-21><active followup><active recruitment><adipose><adulthood><age 17 years><age 18 years><age group><aged><ages><clinical center><cohort><comparator group><comparison group><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><developmental><eighteen year old><eighteen years of age><endurance exercise><enroll><ethnic minority><exercise intervention><exercise training><falls><follow up><follow-up><followed up><followup><improved><innovate><innovation><innovative><insight><interventional strategy><kids><men><multiomics><multiple omics><muscular><novel><operation><operations><pandemic><pandemic disease><panomics><pathway><pediatric><phenotypic data><physical activity intervention><pre-clinical><preclinical><public data base><public database><publicly accessible data base><publicly accessible database><publicly available data base><publicly available database><quality assurance><racial><racial background><racial minority><racial origin><randomisation><randomization><randomized control trial><randomly assigned><recruit><resistance exercise><resistance training><response><sedentary><seventeen year old><seventeen years of age><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex><white adipose tissue><work group><working group><yellow adipose tissue><youngster>