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9873 documents

SOCAL: Privacy-protecting Sharing Of Clinical Data Across Laboratories

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Tsung-Ting Kuo · YALE UNIVERSITY · 2024 · $343,314 — Project Summary Privacy and security of personal information has become one of the major grand challenges in modern society, especially for healthcare studies. Re-identification risks and data breaches require new policies and regulations for data sharing across healthcare institutions and research …

Big Data Health Science Fellow Program in Infectious Disease Research

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Xiaoming Li · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $209,329 — Abstract The multiple, massive, and rich Big Data streams in healthcare (e.g., electronic health records, mobile technologies, wearable devices, genomic data) and the emergence of advanced information and computational technologies (e.g., machine learning and artificial intelligence) offer an invalu…

Developing a modified brief alcohol-focused intervention tailored for patients with alcohol use disorder in opioid agonist treatment

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Ryan W Carpenter · UNIVERSITY OF NOTRE DAME · 2024 · $94,010 — 7. Project Summary/Abstract This K23 Mentored Patient-Oriented Research Career Development Award involves complementary research and training plans to develop and then pilot a modified motivational enhancement therapy and cognitive behavioral therapy (MET-CBT) intervention tailored to target alcohol…

Early Drivers of Humoral Immunity to SARS-CoV-2 Infections

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Christopher L King · CASE WESTERN RESERVE UNIVERSITY · 2024 · $303,268 — Abstract The duration and nature of humoral immunity to SARS-CoV-2 (CoV2) infection need to be better understood. While most studies have focused on the immune response in patients with clinical illness, little is known about the antibody response to CoV2 immediately after exposure and before the on…

I-CARE 2 RCT: Mobile Telehealth to Reduce Alzheimer's-related Symptoms for Caregivers and Patients

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MALAZ BOUSTANI · TRUSTEES OF INDIANA UNIVERSITY · 2024 · $130,721 — PROJECT SUMMARY/ABSTRACT Among patients with Alzheimer’s disease and related dementias (ADRD) and their informal caregivers, behavioral and psychological symptoms of dementia (BPSD) are a critical need requiring scalable, evidence- based intervention. As many as 97% of patients with ADRD will ultima…

Mucosal B-cell aging in PLWH

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Marta Epeldegui · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $392,709 — PROJECT SUMMARY/ABSTRACT Overall, the world population is aging and in the era of anti-retroviral therapy (ART) people living with HIV (PLWH) live longer. ART has converted HIV infection into a survivable chronic infection; however, comorbidities are a mounting clinical reality, likely related to ac…

Emerging infections: surveillance, epidemiology and pathogenesis

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

DAVID WANG · WASHINGTON UNIVERSITY · 2024 · $1,615,955 — SUMMARY To prepare for the next emerging infection, our goal is to establish a state-of-the-art Emerging Infectious Diseases Research Center with surveillance for the key disease syndromes – respiratory disease, encephalitis and fever of unknown origin– that have been observed most frequently assoc…

Impact of structural racism on hospital/clinic closures, community assets, and health outcomes in urban communities

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Leonard E. Egede · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $423,837 — Project Summary/Abstract Structural racism, defined as the ways in which societies foster discrimination through mutually reinforcing inequitable systems, has emerged as an important social risk factor and contributor to poor health outcomes for racial/ethnic minorities (Egede 2020, Bailey 2017). S…

Macrophage-targeted dendrimer 2-PMPA for the treatment of age-related sarcopenia

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Ahmet Hoke · JOHNS HOPKINS UNIVERSITY · 2024 · $580,168 — PROJECT SUMMARY Age-related loss of muscle mass, or sarcopenia, is a hallmark of aging that affects up to 20% of those over 65 and up to 50% of those over 80, for which there are no pharmacological treatments. We recently discovered that the enzyme Glutamate Carboxypeptidase II (GCPII), which cataly…

COVID-19 Vaccinations and School / Community Resources: Children's Longitudinal Health and Education Outcomes Using Linked Administrative Data

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Brian Elbel · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $662,456 — PROJECT SUMMARY/ABSTRACT This research will examine how significant disruptions to children’s health, education and overall well-being during the COVID-19 pandemic created lasting influence on health, development and social trajectories through the lifecourse, and the risk for long-term health outco…

A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JONATHAN Edward ALPERT · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $839,995 — PROJECT SUMMARY / ABSTRACT In response to PAR-20-237, “community interventions to address the consequences of the COVID-19 pandemic among health disparity and vulnerable populations,” we propose to study a parent-focused mentalizing intervention with a smartphone health platform in vulnerable popula…

Delivering Evidence-Based Parenting Services to Families in Child Welfare Using Telehealth

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MONICA L OXFORD · UNIVERSITY OF WASHINGTON · 2024 · $661,957 — ABSTRACT The severe acute respiratory syndrome coronavirus 2 (denoted COVID-19) pandemic has shaken the foundation of services delivered to vulnerable families involved with or monitored by the child protective/welfare system. COVID-19 has changed the landscape of how children and families interact …

The Roybal Center for Therapeutic Optimization using Behavioral Science

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Niteesh K Choudhry · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $1,131,543 — The evidence-based use of prescription medications has led to substantial improvement in healthy aging. Despite this, the use of medications by patients and providers remains suboptimal. Many patients are not prescribed guideline-recommended therapies from which they would benefit; among those for w…

Potential New Barriers to Home Health Access for People with Alzheimer's Disease and Related Dementias

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Sara Knox · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $137,835 — I am an assistant professor in the Division of Physical Therapy in the College of Health Professions at the Medical University of South Carolina in Charleston, South Carolina. My long-term goal is to become a well-funded, independent researcher investigating post-acute care of individuals with Alzhe…

21/24 Healthy Brain and Child Development National Consortium

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Douglas Carl Dean III · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $1,773,841 — Project Summary/Abstract Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal sub…

Kentucky Center for Clinical and Translational Science

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

KATHERINE E HARTMANN · UNIVERSITY OF KENTUCKY · 2024 · $3,319,918 — Contact PD/PI: Kern, Philip A. PROJECT SUMMARY – OVERALL The University of Kentucky (UK) Center for Clinical and Translational Science (CCTS) has created an integrated home for clinical and translational research which promotes scientific progress and discoveries at every phase of the translational…

Improving Data Collection of Debt and Financial Strain to Assess Health Impacts of Economic Insecurity

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Lawrence M Berger · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $660,124 — Project Summary/Abstract Individual and household debt plays an increasingly important role in the dynamics of inequality in the United States. However, current data limitations impede scientific understanding of the role of indebtedness in reducing or exacerbating economic insecurity. At best, exis…

Impacts of SARS-CoV-2 Infection and Age on Musculoskeletal Health

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Olatundun Dupe Awosanya · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $41,715 — PROJECT SUMMARY/ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic as of June 14, 2021, has totaled 176.02 million cases, 3.80 million deaths, and 2.37 billion vaccine doses have been administered globally. However, many have suffered prior to the vaccine and have survived or will still suff…

The Institute for Translational Medicine

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Joshua J Jacobs · UNIVERSITY OF CHICAGO · 2024 · $8,219,608 — Contact PD/PI: Solway, Julian Chapter O: Overall ABSTRACT ITM 3.0: ADVANCING HEALTH TOWARD HEALTH EQUITY THROUGHOUT METROPOLITAN CHICAGO The University of Chicago – Rush University Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, adm…

UCLA Clinical and Translational Science Institute

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

ARLEEN F. BROWN · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $9,718,232 — SUMMARY/ABSTRACT The UCLA Clinical and Translational Science Institute is a research partnership of the University of California Los Angeles, Cedars-Sinai Medical Center, Charles R. Drew University of Medicine and Science and the Harbor- UCLA Medical Center/ Lundquist Institute for Biomedical Innova…